USP49 and STING1

Number of citations of the paper that reports this interaction (PubMedID 30943264)
73

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, enzymatic study)

		USP49	STING1
Description		ubiquitin specific peptidase 49	stimulator of interferon response cGAMP interactor 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Golgi Membrane Autophagosome Membrane Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endosome Autophagosome Peroxisome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Cilium Membrane Cytoplasmic Vesicle Membrane Secretory Granule Membrane Cytoplasmic Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Ciliary Basal Body Perinuclear Region Of Cytoplasm Serine/threonine Protein Kinase Complex STING Complex
	Molecular Function	Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Zinc Ion Binding Hydrolase Activity Histone Binding Metal Ion Binding Histone H2B Deubiquitinase Activity	Nucleotide Binding Transcription Coactivator Activity Protein Binding Proton Channel Activity Protein Kinase Binding Ubiquitin Protein Ligase Binding Cyclic-di-GMP Binding Signaling Adaptor Activity Identical Protein Binding Protein Homodimerization Activity 2',3'-cyclic GMP-AMP Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Protein Serine/threonine Kinase Binding
	Biological Process	MRNA Splicing, Via Spliceosome Chromatin Organization Chromatin Remodeling MRNA Processing Proteolysis RNA Splicing Protein Deubiquitination Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction	Autophagosome Assembly Activation Of Innate Immune Response Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Defense Response To Virus By Host Immune System Process Cytoplasmic Pattern Recognition Receptor Signaling Pathway Monoatomic Ion Transport Autophagy Regulation Of Gene Expression Positive Regulation Of Macroautophagy Regulation Of Metabolic Process Signal Transduction Involved In Regulation Of Gene Expression Positive Regulation Of Type I Interferon Production Protein Exit From Endoplasmic Reticulum Positive Regulation Of Interferon-beta Production Monoatomic Ion Transmembrane Transport Cellular Response To Interferon-beta Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Inflammatory Response Protein Complex Oligomerization Defense Response To Virus Positive Regulation Of Type I Interferon-mediated Signaling Pathway Reticulophagy Protein Localization To Endoplasmic Reticulum Cellular Response To Exogenous DsRNA Antiviral Innate Immune Response CGAS/STING Signaling Pathway Positive Regulation Of CGAS/STING Signaling Pathway Positive Regulation Of Cytokine Production Involved In Inflammatory Response Proton Transmembrane Transport
Pathways		Ub-specific processing proteases	STING mediated induction of host immune responses Regulation of innate immune responses to cytosolic DNA STAT6-mediated induction of chemokines IRF3-mediated induction of type I IFN Neutrophil degranulation SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses
Drugs
Diseases
GWAS		Cutaneous psoriasis ( 26626624) Hip circumference adjusted for BMI ( 34021172) Mean corpuscular hemoglobin ( 32888494 20139978) Mean corpuscular volume ( 23263863 27863252 32888494 20139978) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Neutrophil percentage of white cells ( 32888494) Platelet distribution width ( 32888494) Red blood cell count ( 27863252 20139978 32888494) Reticulocyte count ( 32888494) Skin aging (microtopography measurement) ( 28502801) Sleep duration (short sleep) ( 30846698)
Interacting Genes		11 interacting genes: H2BC21 MED17 MED18 MED8 NAMPT PTCD2 RBCK1 STING1 TP53 TRIM35 ZNF774	26 interacting genes: CCDC47 CCDC50 CMTM5 DDOST IFI16 IRAK1 LEPROTL1 LTN1 MBOAT7 MUL1 MYSM1 PLLP REEP6 RNF115 SGPL1 SMIM1 STT3A STX5 SURF4 TECR TMEM100 TRIM10 USP20 USP35 USP49 YIPF2
Entrez ID		25862	340061
HPRD ID		10075	14173
Ensembl ID		ENSG00000164663	ENSG00000184584
Uniprot IDs		Q70CQ1	A0A494C0W5 J3QTB1 Q86WV6 V5V0K2
PDB IDs			4EF4 4EF5 4EMT 4EMU 4F5D 4F5E 4F5W 4F5Y 4F9E 4F9G 4KSY 4LOH 4LOI 4QXO 4QXP 4QXQ 4QXR 5BQX 5JEJ 6CFF 6CY7 6DNK 6DXG 6DXL 6MX0 6MX3 6MXE 6NT5 6O8B 6O8C 6S26 6S27 6S86 6UKM 6UKU 6UKV 6UKW 6UKX 6UKY 6UKZ 6UL0 6XF3 6XF4 6XNP 6Y99 6YDB 6YDZ 6YEA 6YWA 6YWB 6Z0Z 6Z15 7A90 7KVX 7KVZ 7KW1 7MHC 7OB3 7Q3B 7Q85 7R4H 7SHO 7SHP 7SII 7SSM 7T9U 7T9V 7X9P 7X9Q 7ZKU 7ZV0 7ZVK 7ZWL 7ZXB 8A2H 8A2I 8A2J 8A2K 8A2X 8B2J 8FLK 8FLM 8GJX 8GSZ 8GT6 8IK3 8ORW 8P45 8STH 8STI 8T5K 8T5L 9IJN
Enriched GO Terms of Interacting Partners?		Positive Regulation Of DNA-templated Transcription Initiation Positive Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of DNA-templated Transcription Initiation Core Mediator Complex Mediator Complex RNA Polymerase II Preinitiation Complex Assembly Protein-DNA Complex Assembly Positive Regulation Of Transcription Elongation By RNA Polymerase II Transcription Preinitiation Complex Assembly Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Elongation Regulation Of Nucleobase-containing Compound Metabolic Process Protein-containing Complex Assembly Positive Regulation Of Transcription By RNA Polymerase II Ubiquitin Protein Ligase Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Coregulator Activity Protein-containing Complex Organization Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Programmed Necrotic Cell Death Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Biosynthetic Process Protein Ubiquitination Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Nicotinamide Phosphoribosyltransferase Activity Cyclic-di-GMP Binding STING Complex Transcription Coactivator Activity Protein Modification By Small Protein Conjugation Regulation Of Macromolecule Metabolic Process Defense Response Positive Regulation Of Macromolecule Metabolic Process Oligodendrocyte Apoptotic Process Negative Regulation Of Pentose-phosphate Shunt Negative Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate 2',3'-cyclic GMP-AMP Binding Post-translational Protein Modification Negative Regulation Of Fermentation	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Oligosaccharyltransferase Complex A Oligosaccharyltransferase Complex Post-translational Protein Modification Protein Modification Process Early Endosome To Golgi Transport Cysteine-type Deubiquitinase Activity Protein Deubiquitination Protein N-linked Glycosylation Via Asparagine
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?