MED8 and MED7

Number of citations of the paper that reports this interaction (PubMedID 12584197)
0

Data Source:
HPRD (in vitro)

		MED8	MED7
Description		mediator complex subunit 8	mediator complex subunit 7
Image
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Mediator Complex Core Mediator Complex	Ubiquitin Ligase Complex Nucleus Nucleoplasm Transcription Regulator Complex Mediator Complex Nuclear Body Core Mediator Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Coregulator Activity Protein Binding Ubiquitin Protein Ligase Activity	Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Protein Ubiquitination Positive Regulation Of Transcription Elongation By RNA Polymerase II RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II	Regulation Of Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Protein Ubiquitination Positive Regulation Of Transcription Elongation By RNA Polymerase II Somatic Stem Cell Population Maintenance RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II
Pathways		PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation RSV-host interactions	PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation RSV-host interactions MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Feeling worry ( 29500382) Schizophrenia ( 28991256) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Medication use (thyroid preparations) ( 31015401)
Interacting Genes		33 interacting genes: APP ARRB2 CCNC CDK8 CEBPA CTDP1 ELOC HSPB3 KRT40 MED1 MED11 MED12 MED17 MED19 MED20 MED22 MED25 MED26 MED27 MED28 MED30 MED31 MED6 MED7 MED9 PEX14 PHYHIP PNMA1 PRKAR1B SNTA1 THOC7 UBALD1 USP49	22 interacting genes: CAB39 CTDP1 DNMT3L ESR1 ESR2 HAUS1 HGS HNF4A IKBKG LZTR1 MED8 MED9 PCBD2 PML RBFOX2 RELA RHOXF2 SREBF1 TRIM15 TRIM29 UBE2I ZSCAN1
Entrez ID		112950	9443
HPRD ID		06991	05439
Ensembl ID		ENSG00000159479	ENSG00000155868
Uniprot IDs		Q96G25	O43513 Q6IAZ5
PDB IDs		7EMF 7ENA 7ENC 7ENJ 7LBM 7NVR 8GXQ 8GXS 8T9D 8TQW 8TRH	7EMF 7ENA 7ENC 7ENJ 7LBM 7NVR 8GXQ 8GXS 8T9D 8TQW 8TRH
Enriched GO Terms of Interacting Partners?		Mediator Complex Core Mediator Complex Positive Regulation Of DNA-templated Transcription Initiation Regulation Of DNA-templated Transcription Initiation Positive Regulation Of Transcription Initiation By RNA Polymerase II RNA Polymerase II Preinitiation Complex Assembly Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of Transcription Elongation By RNA Polymerase II Transcription Preinitiation Complex Assembly Positive Regulation Of DNA-templated Transcription, Elongation Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of DNA-templated Transcription Elongation Protein-DNA Complex Assembly Transcription Coregulator Activity Positive Regulation Of Transcription By RNA Polymerase II Ubiquitin Ligase Complex Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Protein-containing Complex Assembly Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Somatic Stem Cell Population Maintenance Positive Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Protein-containing Complex Organization Regulation Of Nucleobase-containing Compound Metabolic Process Protein Ubiquitination Positive Regulation Of Macromolecule Metabolic Process Post-translational Protein Modification Nucleoplasm Transcription Coactivator Activity Protein Modification By Small Protein Conjugation Stem Cell Population Maintenance Maintenance Of Cell Number Positive Regulation Of Metabolic Process Nuclear Vitamin D Receptor Binding Ubiquitin Protein Ligase Activity Nucleus Transcription Initiation At RNA Polymerase II Promoter CKM Complex Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Nuclear Thyroid Hormone Receptor Binding DNA-templated Transcription Initiation Cellular Component Assembly	Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Intracellular Receptor Signaling Pathway Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Nuclear Receptor Activity Regulation Of Metabolic Process Hormone-mediated Signaling Pathway Negative Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Metabolic Process Estrogen Receptor Signaling Pathway Negative Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Receptor-mediated Signaling Pathway Nuclear Estrogen Receptor Activity Positive Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-binding Transcription Factor Activity Transcription Coregulator Binding Intracellular Signal Transduction RNA Polymerase II Preinitiation Complex Assembly Zinc Ion Binding Negative Regulation Of Cell Growth Canonical NF-kappaB Signal Transduction Transcription Preinitiation Complex Assembly Regulation Of DNA-binding Transcription Factor Activity Estrogen Response Element Binding Positive Regulation Of Transcription By RNA Polymerase II Regulation Of MiRNA Transcription Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Enzyme Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Growth Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of MiRNA Metabolic Process Suppression Of Viral Release By Host Negative Regulation Of Biosynthetic Process Sequence-specific DNA Binding
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