MED8 and PRKAR1B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MED8	PRKAR1B
Description		mediator complex subunit 8	protein kinase cAMP-dependent type I regulatory subunit beta
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Mediator Complex Core Mediator Complex	Cytoplasm Multivesicular Body Cytosol Plasma Membrane CAMP-dependent Protein Kinase Complex Membrane Synapse Ciliary Base Schaffer Collateral - CA1 Synapse Hippocampal Mossy Fiber To CA3 Synapse Postsynapse Glutamatergic Synapse
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Coregulator Activity Protein Binding Ubiquitin Protein Ligase Activity	Nucleotide Binding CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding CAMP-dependent Protein Kinase Regulator Activity CAMP Binding Protein Kinase A Catalytic Subunit Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Protein Ubiquitination Positive Regulation Of Transcription Elongation By RNA Polymerase II RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II	Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Learning Or Memory Modulation Of Chemical Synaptic Transmission Regulation Of Synaptic Vesicle Cycle Negative Regulation Of CAMP/PKA Signal Transduction Positive Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Fear Response Positive Regulation Of Excitatory Postsynaptic Potential
Pathways		PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation RSV-host interactions	PKA activation PKA activation in glucagon signalling DARPP-32 events Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins CREB1 phosphorylation through the activation of Adenylate Cyclase Hedgehog 'off' state GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis Factors involved in megakaryocyte development and platelet production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Feeling worry ( 29500382) Schizophrenia ( 28991256) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Body size at age 10 ( 32376654) Femur bone mineral density x serum urate levels interaction ( 34046847) Hematocrit ( 27863252 32888494) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Plasma free amino acid levels ( 30659259) Red blood cell count ( 27863252 32888494)
Interacting Genes		33 interacting genes: APP ARRB2 CCNC CDK8 CEBPA CTDP1 ELOC HSPB3 KRT40 MED1 MED11 MED12 MED17 MED19 MED20 MED22 MED25 MED26 MED27 MED28 MED30 MED31 MED6 MED7 MED9 PEX14 PHYHIP PNMA1 PRKAR1B SNTA1 THOC7 UBALD1 USP49	75 interacting genes: AKAP1 AKAP14 ANKS1A BAG3 BAG6 BOD1L2 CAMSAP1 CBX8 CCDC187 CDC37 CDKN1A CEP19 COX5B DACH1 DNAAF19 DTNB EEF2KMT EGFR FAM161A FAM90A1 FCHSD2 GAS2L2 GLIS2 GNL3L GOLGA1 GPKOW GUCA1A IGFN1 INPP5J KANK2 KIF5B L3MBTL2 LENG1 LNX1 MBD3 MED8 MYO15B NTAQ1 NXF1 PIK3R3 POLE4 PPP1R9A PRKAA2 PRKAR1A PRPF18 PSMG1 QRICH1 RARG RUNX1T1 SAP30BP SH2D4A SHC3 SMAD3 SMAD4 SMG9 SNW1 STK16 SYTL4 TASOR2 TEAD4 THRA TSGA10IP UACA UBC VEZF1 WNK1 WRN ZBTB16 ZMYND19 ZNF177 ZNF329 ZNF35 ZNF410 ZNF559-ZNF177 ZNF76
Entrez ID		112950	5575
HPRD ID		06991	01485
Ensembl ID		ENSG00000159479	ENSG00000188191
Uniprot IDs		Q96G25	P31321
PDB IDs		7EMF 7ENA 7ENC 7ENJ 7LBM 7NVR 8GXQ 8GXS 8T9D 8TQW 8TRH	4DIN 4F9K
Enriched GO Terms of Interacting Partners?		Mediator Complex Core Mediator Complex Positive Regulation Of DNA-templated Transcription Initiation Regulation Of DNA-templated Transcription Initiation Positive Regulation Of Transcription Initiation By RNA Polymerase II RNA Polymerase II Preinitiation Complex Assembly Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of Transcription Elongation By RNA Polymerase II Transcription Preinitiation Complex Assembly Positive Regulation Of DNA-templated Transcription, Elongation Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of DNA-templated Transcription Elongation Protein-DNA Complex Assembly Transcription Coregulator Activity Positive Regulation Of Transcription By RNA Polymerase II Ubiquitin Ligase Complex Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Protein-containing Complex Assembly Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Somatic Stem Cell Population Maintenance Positive Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Protein-containing Complex Organization Regulation Of Nucleobase-containing Compound Metabolic Process Protein Ubiquitination Positive Regulation Of Macromolecule Metabolic Process Post-translational Protein Modification Nucleoplasm Transcription Coactivator Activity Protein Modification By Small Protein Conjugation Stem Cell Population Maintenance Maintenance Of Cell Number Positive Regulation Of Metabolic Process Nuclear Vitamin D Receptor Binding Ubiquitin Protein Ligase Activity Nucleus Transcription Initiation At RNA Polymerase II Promoter CKM Complex Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Nuclear Thyroid Hormone Receptor Binding DNA-templated Transcription Initiation Cellular Component Assembly	Protein Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Metabolic Process Regulation Of RNA Biosynthetic Process Apoptotic Signaling Pathway Ciliary Basal Body Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Protein Localization Retinoic Acid Receptor Signaling Pathway RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage SMAD Protein Complex Protein Folding Chaperone Complex Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Heteromeric SMAD Protein Complex Regulation Of Transforming Growth Factor Beta2 Production Regulation Of Macromolecule Biosynthetic Process DNA Binding Zinc Ion Binding Nuclear Speck DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Intracellular Signal Transduction DNA-binding Transcription Factor Activity In Utero Embryonic Development Regulation Of Gene Expression Chordate Embryonic Development Positive Regulation Of RNA Metabolic Process Positive Regulation Of Extracellular Matrix Assembly CAMP-dependent Protein Kinase Complex Protein Carrier Chaperone Regulation Of Vitamin D Receptor Signaling Pathway Regulation Of Primary Metabolic Process Cytoplasm Nucleus
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