USP49 and TRIM35

Number of citations of the paper that reports this interaction (PMID 23105109)
4

Data Source:
BioGRID (two hybrid)

		USP49	TRIM35
Gene Name		ubiquitin specific peptidase 49	tripartite motif containing 35
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Protein Binding Zinc Ion Binding Histone Binding	Molecular_function Zinc Ion Binding
	Biological Process	MRNA Splicing, Via Spliceosome Protein Deubiquitination Histone H2B Conserved C-terminal Lysine Deubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process	Apoptotic Process Negative Regulation Of Cell Proliferation Positive Regulation Of Apoptotic Process Innate Immune Response Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Viral Release From Host Cell
Pathways			Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system
Drugs
Diseases
GWAS		Mean corpuscular hemoglobin ( 20139978) Mean corpuscular volume ( 23263863 20139978) Red blood cell count ( 20139978)
Protein-Protein Interactions		6 interactors: HIST2H2BE MED17 MED18 MED8 RBCK1 TRIM35	13 interactors: PAN2 TRIM11 TRIM5 TSG101 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2K UBE2U UBE2W USP2 USP49
Entrez ID		25862	23087
HPRD ID		10075	15553
Ensembl ID		ENSG00000164663	ENSG00000104228
Uniprot IDs		Q70CQ1	E5RGB3 Q9UPQ4
PDB IDs
Enriched GO Terms of Interacting Partners?			Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Catabolic Process Protein K48-linked Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Protein Modification Process Catabolic Process Proteolysis Cellular Protein Metabolic Process Protein K11-linked Ubiquitination Protein Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Innate Immune Response Positive Regulation Of Innate Immune Response Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of Proteasomal Protein Catabolic Process Regulation Of DNA-templated Transcription In Response To Stress TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Innate Immune Response Toll-like Receptor 4 Signaling Pathway Response To Stress Cellular Metabolic Process Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Toll-like Receptor Signaling Pathway Cellular Response To Oxygen Levels Negative Regulation Of Viral Release From Host Cell Immune Response Negative Regulation Of Viral Entry Into Host Cell Defense Response Regulation Of Protein Catabolic Process Regulation Of Viral Entry Into Host Cell Regulation Of Viral Release From Host Cell Cellular Response To Stress Immune Response-regulating Signaling Pathway Protein K63-linked Ubiquitination Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription
Tagcloud ?		affects cotranscriptional deubiquitinase deubiquitinates deubiquitination dramatically eukaryotes exons h2b identifies intronic knockdown like1 modulated nascent nucleosome peptidase purification relatively ruvb rvb1 splicing sug1 u1a u2b ubiquitination uh2b uncovers upstream	advance advantage blockade box coil coiled collectively consisting doi hcc hepatocellular isoform m2 onc oncogene online pkm2 publication pyruvate rbcc reprogramming september suppress suppresses tripartite tumorigenicity uses warburg y105
Tagcloud (Difference) ?		affects cotranscriptional deubiquitinase deubiquitinates deubiquitination dramatically eukaryotes exons h2b identifies intronic knockdown like1 modulated nascent nucleosome peptidase purification relatively ruvb rvb1 splicing sug1 u1a u2b ubiquitination uh2b uncovers upstream	advance advantage blockade box coil coiled collectively consisting doi hcc hepatocellular isoform m2 onc oncogene online pkm2 publication pyruvate rbcc reprogramming september suppress suppresses tripartite tumorigenicity uses warburg y105
Tagcloud (Intersection) ?