DFNB31 and CASK

Number of citations of the paper that reports this interaction (PMID 12641734)
9

Data Source:
HPRD (two hybrid, in vivo)

		DFNB31	CASK
Gene Name		deafness, autosomal recessive 31	calcium/calmodulin-dependent serine protein kinase (MAGUK family)
Image
Gene Ontology Annotations	Cellular Component	Stereocilia Ankle Link Complex Cytoplasm Actin Filament Growth Cone Photoreceptor Connecting Cilium Stereocilium Periciliary Membrane Compartment	Basement Membrane Nuclear Lamina Nucleolus Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Focal Adhesion Actin Cytoskeleton Basolateral Plasma Membrane Nuclear Matrix Presynaptic Membrane Ciliary Membrane
	Molecular Function	Protein Binding	Guanylate Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding Calmodulin Binding ATP Binding Neurexin Family Protein Binding
	Biological Process	Retina Homeostasis Sensory Perception Of Sound Positive Regulation Of Gene Expression Sensory Perception Of Light Stimulus Inner Ear Receptor Stereocilium Organization	Negative Regulation Of Cell-matrix Adhesion Protein Phosphorylation Cell Adhesion Negative Regulation Of Keratinocyte Proliferation Extracellular Matrix Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Nucleotide Phosphorylation Negative Regulation Of Wound Healing Calcium Ion Import Positive Regulation Of Calcium Ion Import Negative Regulation Of Cellular Response To Growth Factor Stimulus
Pathways			Syndecan interactions Nephrin interactions Non-integrin membrane-ECM interactions
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		5 interactors: CASK LRP4 LRRC4C MYO15A MYO7A	60 interactors: APBA1 ATP2B4 BNIP3L C16orf70 CADM1 CASKIN1 CDK9 CNTNAP2 CNTNAP4 DFNB31 DLG1 DLG4 DUSP3 ELL2 EPB41 EPS8 ERBB2IP F11R FCHSD2 GCNT3 GLS2 GRIK2 GRIN2A HGS ID1 IL15RA IL18 KCNA4 KCNJ12 KCNJ2 KCNJ4 LIN7A LIN7B MARS MLLT6 NPHS1 NRXN1 NRXN2 NRXN3 P2RX7 PARK2 PCBP2 PCM1 PLK2 PRKD2 PTGS2 RAB3A RPH3A SDC1 SDC2 SDC3 SDC4 SH2D4A SMEK1 SRPK2 TANC1 TBR1 TRIM22 TSPYL2 WNT7B
Entrez ID		25861	8573
HPRD ID		09718	02164
Ensembl ID		ENSG00000095397	ENSG00000147044
Uniprot IDs		B9EGE6 Q9P202	O14936
PDB IDs		1UEZ 1UF1 1UFX	1KGD 1KWA 1ZL8 3C0G 3C0H 3C0I 3MFR 3MFS 3MFT 3MFU 3TAC
Enriched GO Terms of Interacting Partners?		Inner Ear Morphogenesis System Development Embryonic Morphogenesis Ear Morphogenesis Multicellular Organismal Development Anatomical Structure Development Synaptic Growth At Neuromuscular Junction Positive Regulation Of Presynaptic Membrane Organization Sensory Perception Of Sound Regulation Of Axonogenesis Sensory Perception Of Mechanical Stimulus Inner Ear Development Developmental Process Organ Morphogenesis Ear Development Regulation Of Presynaptic Membrane Organization Embryo Development Organ Development Epidermis Development Postsynaptic Membrane Assembly Equilibrioception Presynaptic Membrane Assembly Post-embryonic Organ Morphogenesis Embryonic Organ Morphogenesis Auditory Receptor Cell Stereocilium Organization Presynaptic Membrane Organization Skeletal Muscle Acetylcholine-gated Channel Clustering Extracellular Matrix Organization Extracellular Structure Organization Negative Regulation Of Keratinocyte Proliferation Regulation Of Neuron Projection Development Generation Of Neurons Auditory Receptor Cell Morphogenesis Phagolysosome Assembly Positive Regulation Of Calcium Ion Import Neurogenesis Protein Heterotetramerization Auditory Receptor Cell Development Regulation Of Cell Morphogenesis Regulation Of Cell Projection Organization Embryonic Organ Development Inner Ear Receptor Stereocilium Organization Regulation Of Keratinocyte Proliferation Membrane Assembly Regulation Of Calcium Ion Import Regulation Of Neuron Differentiation Membrane Biogenesis Cell Morphogenesis Involved In Neuron Differentiation Sensory Organ Development Postsynaptic Membrane Organization	Synaptic Transmission Signaling Cell Communication Cell-cell Signaling Regulation Of Neurotransmitter Levels Learning Vocalization Behavior Neurotransmitter Secretion Neurotransmitter Transport Single-organism Behavior Learning Or Memory Behavior Cognition Establishment Or Maintenance Of Apical/basal Cell Polarity Cellular Protein Localization Cellular Localization Response To External Stimulus Anatomical Structure Development Social Behavior Cellular Component Assembly Regulation Of Synaptic Transmission System Development Regulation Of Cellular Component Organization Response To Stimulus Synapse Organization Regulation Of Grooming Behavior Regulation Of Organelle Organization Protein Localization To Membrane Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Response To Abiotic Stimulus Multicellular Organismal Development Regulation Of Ion Transport Protein Localization Secretion By Cell Membrane Depolarization Developmental Process Anatomical Structure Morphogenesis Neurological System Process Maintenance Of Apical/basal Cell Polarity Cell Adhesion Membrane Organization Receptor Localization To Synapse Regulation Of Cellular Localization Synapse Assembly Regulation Of Signaling Positive Regulation Of Transport Angiogenesis Regulation Of Intracellular Signal Transduction Secretion Positive Regulation Of Exosomal Secretion
Tagcloud ?		blindness cytoskeletal deaf drosophila dsychronic dysc electrophysiological enlarged expand larvae larval misshapen neuromuscular neurotransmission neurotransmitter pdz potassium presynaptically scaffold slo slowpoke synapse synapses synaptic uncover usher whirlin zone zones	channels clustering coclusters coimmunoprecipitates colocalizes constituent cooh enzymatic fact gk gkap guanylate heterologous homology isolation junction lin maguk nh2 obscure organization pdz postsynaptic psd sap90 sh3 synaptic termed zo
Tagcloud (Difference) ?		blindness cytoskeletal deaf drosophila dsychronic dysc electrophysiological enlarged expand larvae larval misshapen neuromuscular neurotransmission neurotransmitter potassium presynaptically scaffold slo slowpoke synapse synapses uncover usher whirlin zone zones	channels clustering coclusters coimmunoprecipitates colocalizes constituent cooh enzymatic fact gk gkap guanylate heterologous homology isolation junction lin maguk nh2 obscure organization postsynaptic psd sap90 sh3 termed zo
Tagcloud (Intersection) ?		pdz synaptic