WHRN and SPC24

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		WHRN	SPC24
Description		whirlin	SPC24 component of NDC80 kinetochore complex
Image
GO Annotations	Cellular Component	Photoreceptor Inner Segment Stereocilia Ankle Link Stereocilia Ankle Link Complex Cytoplasm Actin Filament Plasma Membrane Cilium Growth Cone Photoreceptor Connecting Cilium Stereocilium Stereocilium Bundle Stereocilium Tip Ciliary Basal Body Cell Projection Neuron Projection Neuronal Cell Body Synapse Periciliary Membrane Compartment USH2 Complex	Chromosome, Centromeric Region Kinetochore Outer Kinetochore Nucleus Nucleoplasm Chromosome Nucleolus Cytosol Ndc80 Complex
	Molecular Function	Protein Binding Identical Protein Binding	Protein Binding Microtubule Binding
	Biological Process	Retina Homeostasis Sensory Perception Of Sound Positive Regulation Of Gene Expression Cerebellar Purkinje Cell Layer Formation Establishment Of Protein Localization Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Sensory Perception Of Light Stimulus Establishment Of Localization In Cell Auditory Receptor Cell Stereocilium Organization Inner Ear Receptor Cell Differentiation Inner Ear Receptor Cell Stereocilium Organization Paranodal Junction Maintenance	Chromosome Segregation Mitotic Spindle Assembly Checkpoint Signaling Attachment Of Spindle Microtubules To Kinetochore Cell Division
Pathways		Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases		Deafness, autosomal recessive Usher syndrome (US)
GWAS			Apolipoprotein A1 levels ( 32203549) Appendicular lean mass ( 33097823) Coronary artery disease ( 33020668) Cortisol levels (saliva) ( 28843169) Haemorrhoidal disease ( 33888516) HDL cholesterol ( 23505323) HDL cholesterol levels ( 32203549) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Intraocular pressure ( 29617998) Lipid traits ( 24386095) Low density lipoprotein cholesterol levels ( 30718733) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Voxel-wise structural brain imaging measurements in Alzheimer’s disease ( 31095298)
Interacting Genes		17 interacting genes: BEND7 BMI1 CASK COL17A1 EFHC1 GOLGA2 GPSM2 HEMGN KEAP1 LRP4 LRRC4C MYO15A MYO7A PXN RPS6KA1 SPC24 TPRN	7 interacting genes: APP PSEN2 SKA1 SKA2 SKA3 SUOX WHRN
Entrez ID		25861	147841
HPRD ID		09718	15464
Ensembl ID		ENSG00000095397	ENSG00000161888
Uniprot IDs		B9EGE6 Q9P202	Q8NBT2
PDB IDs		1UEZ 1UF1 1UFX 6KZ1 7EP7	2VE7 3IZ0 8PPR 8Q5H
Enriched GO Terms of Interacting Partners?		Stereocilium Base Stereocilium Mitotic Spindle Organization Auditory Receptor Cell Stereocilium Organization	SKA Complex Establishment Of Meiotic Spindle Orientation Establishment Of Meiotic Spindle Localization Spindle Assembly Involved In Female Meiosis Meiotic Spindle Assembly Outer Kinetochore Attachment Of Mitotic Spindle Microtubules To Kinetochore Meiotic Spindle Organization Kinetochore Mitotic Sister Chromatid Segregation Attachment Of Spindle Microtubules To Kinetochore Sister Chromatid Segregation Spindle Microtubule Establishment Of Spindle Orientation Mitotic Metaphase Chromosome Alignment Nuclear Chromosome Segregation Establishment Of Spindle Localization Metaphase Chromosome Alignment Negative Regulation Of Mitotic Spindle Assembly Checkpoint Signaling Spindle Localization Chromosome Localization Positive Regulation Of Mitotic Sister Chromatid Segregation Spindle Assembly Regulation Of Microtubule Polymerization Or Depolymerization Positive Regulation Of Mitotic Cell Cycle Meiotic Spindle Organelle Localization Chromosome Segregation Mitotic Cell Cycle Positive Regulation Of Mitotic Metaphase/anaphase Transition Spindle Organization Chromosome, Centromeric Region Regulation Of Microtubule Cytoskeleton Organization Positive Regulation Of Mitotic Sister Chromatid Separation Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Positive Regulation Of Chromosome Segregation Positive Regulation Of Chromosome Separation Spindle Establishment Of Localization In Cell Microtubule Binding Regulation Of Microtubule-based Process Establishment Of Organelle Localization Membraneless Organelle Assembly Microtubule-based Process Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Cell Cycle Chromosome Organization Microtubule Regulation Of Mitotic Sister Chromatid Separation Synaptic Membrane
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