DFNB31 and LRP4

Number of citations of the paper that reports this interaction (PMID 12421765)
28

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		DFNB31	LRP4
Gene Name		deafness, autosomal recessive 31	low density lipoprotein receptor-related protein 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Stereocilia Ankle Link Complex Cytoplasm Actin Filament Growth Cone Photoreceptor Connecting Cilium Stereocilium Periciliary Membrane Compartment	Cell Surface Postsynaptic Density Integral Component Of Membrane Flotillin Complex Dendrite Neuromuscular Junction Neuronal Cell Body Synaptic Membrane
	Molecular Function	Protein Binding	Calcium Ion Binding Protein Binding Receptor Tyrosine Kinase Binding Apolipoprotein Binding Protein Homodimerization Activity Scaffold Protein Binding
	Biological Process	Retina Homeostasis Sensory Perception Of Sound Positive Regulation Of Gene Expression Sensory Perception Of Light Stimulus Inner Ear Receptor Stereocilium Organization	Kidney Development Regulation Of Protein Phosphorylation Hair Follicle Development Endocytosis Dorsal/ventral Pattern Formation Proximal/distal Pattern Formation Wnt Signaling Pathway Extracellular Matrix Organization Negative Regulation Of Ossification Odontogenesis Of Dentin-containing Tooth Embryonic Digit Morphogenesis Dendrite Morphogenesis Negative Regulation Of Axonogenesis Synapse Organization Synaptic Growth At Neuromuscular Junction Protein Heterotetramerization Limb Development Skeletal Muscle Acetylcholine-gated Channel Clustering Negative Regulation Of Canonical Wnt Signaling Pathway Postsynaptic Membrane Assembly Presynaptic Membrane Assembly Positive Regulation Of Presynaptic Membrane Organization
Pathways			ECM proteoglycans
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)	Bone mineral density (hip) ( 19079262) D-dimer levels ( 21502573) HDL cholesterol ( 20686565)
Protein-Protein Interactions		5 interactors: CASK LRP4 LRRC4C MYO15A MYO7A	1 interactors: DFNB31
Entrez ID		25861	4038
HPRD ID		09718	18517
Ensembl ID		ENSG00000095397	ENSG00000134569
Uniprot IDs		B9EGE6 Q9P202	O75096
PDB IDs		1UEZ 1UF1 1UFX
Enriched GO Terms of Interacting Partners?		Inner Ear Morphogenesis System Development Embryonic Morphogenesis Ear Morphogenesis Multicellular Organismal Development Anatomical Structure Development Synaptic Growth At Neuromuscular Junction Positive Regulation Of Presynaptic Membrane Organization Sensory Perception Of Sound Regulation Of Axonogenesis Sensory Perception Of Mechanical Stimulus Inner Ear Development Developmental Process Organ Morphogenesis Ear Development Regulation Of Presynaptic Membrane Organization Embryo Development Organ Development Epidermis Development Postsynaptic Membrane Assembly Equilibrioception Presynaptic Membrane Assembly Post-embryonic Organ Morphogenesis Embryonic Organ Morphogenesis Auditory Receptor Cell Stereocilium Organization Presynaptic Membrane Organization Skeletal Muscle Acetylcholine-gated Channel Clustering Extracellular Matrix Organization Extracellular Structure Organization Negative Regulation Of Keratinocyte Proliferation Regulation Of Neuron Projection Development Generation Of Neurons Auditory Receptor Cell Morphogenesis Phagolysosome Assembly Positive Regulation Of Calcium Ion Import Neurogenesis Protein Heterotetramerization Auditory Receptor Cell Development Regulation Of Cell Morphogenesis Regulation Of Cell Projection Organization Embryonic Organ Development Inner Ear Receptor Stereocilium Organization Regulation Of Keratinocyte Proliferation Membrane Assembly Regulation Of Calcium Ion Import Regulation Of Neuron Differentiation Membrane Biogenesis Cell Morphogenesis Involved In Neuron Differentiation Sensory Organ Development Postsynaptic Membrane Organization	Inner Ear Receptor Stereocilium Organization Inner Ear Receptor Cell Development Retina Homeostasis Inner Ear Receptor Cell Differentiation Mechanoreceptor Differentiation Sensory Perception Of Sound Sensory Perception Of Light Stimulus Tissue Homeostasis Sensory Perception Of Mechanical Stimulus Inner Ear Development Ear Development Multicellular Organismal Homeostasis
Tagcloud ?		blindness cytoskeletal deaf drosophila dsychronic dysc electrophysiological enlarged expand larvae larval misshapen neuromuscular neurotransmission neurotransmitter pdz potassium presynaptically scaffold slo slowpoke synapse synapses synaptic uncover usher whirlin zone zones	acetylcholine achr agrin apoe app clustering cooperate doi dx ecd elife govern hetero http intriguingly lethality musk myotubes neuromuscular nmj nmjs obligate oligomeric operatively org perinatal retardation synapse synergistically
Tagcloud (Difference) ?		blindness cytoskeletal deaf drosophila dsychronic dysc electrophysiological enlarged expand larvae larval misshapen neurotransmission neurotransmitter pdz potassium presynaptically scaffold slo slowpoke synapses synaptic uncover usher whirlin zone zones	acetylcholine achr agrin apoe app clustering cooperate doi dx ecd elife govern hetero http intriguingly lethality musk myotubes nmj nmjs obligate oligomeric operatively org perinatal retardation synergistically
Tagcloud (Intersection) ?		neuromuscular synapse