MOB4 and EPS15

Number of citations of the paper that reports this interaction (PMID 11872741)
14

Data Source:
HPRD (two hybrid, in vitro)

		MOB4	EPS15
Gene Name		MOB family member 4, phocein	epidermal growth factor receptor pathway substrate 15
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol Golgi Cisterna Membrane Neuronal Cell Body Dendritic Spine Perinuclear Region Of Cytoplasm	Cytoplasm Cytosol Plasma Membrane Coated Pit Membrane AP-2 Adaptor Complex Early Endosome Membrane Intracellular Membrane-bounded Organelle Ciliary Membrane
	Molecular Function	Protein Binding Kinase Binding Metal Ion Binding	Calcium Ion Binding Protein Binding SH3 Domain Binding Polyubiquitin Binding Identical Protein Binding
	Biological Process	Transport	Golgi To Endosome Transport Endocytosis Epidermal Growth Factor Receptor Signaling Pathway Cell Proliferation Protein Transport Vesicle Organization Endocytic Recycling Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Clathrin Coat Assembly
Pathways			Signaling by EGFR EGFR downregulation Signaling by EGFR in Cancer Signaling by Ligand-Responsive EGFR Variants in Cancer Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by EGFRvIII in Cancer
Drugs
Diseases
GWAS			IgE grass sensitization ( 22036096)
Protein-Protein Interactions		31 interactors: ARHGEF15 CCDC85B CRMP1 DNM1 EGFR EGLN2 ELK1 EPS15 FADD FBLN1 GDF9 KIDINS220 LATS1 LATS2 LRIF1 MCM2 MED10 MED31 MYL6 MYO9B NME2 PAICS PLEKHM1 PTPRS RAPGEF2 SCMH1 SETDB1 STK11 STK3 THAP4 UBE2V2	42 interactors: AGFG1 AGFG2 AP2A1 AP2A2 CLINT1 CORO7 CRK DNM1 DNM2 EGFR ELF3 EPN1 EPN2 GRB2 HGS ITSN1 ITSN2 LAPTM5 MOB4 NAGPA NEDD4 NUMB NUMBL OPTN PARK2 REPS2 RNF11 SCAMP1 SNAP91 SPG20 STAM2 STAMBP STON2 SYNJ1 TFAP2A UBB UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2H UBQLN1
Entrez ID		25843	2060
HPRD ID		10165	08968
Ensembl ID		ENSG00000115540	ENSG00000085832
Uniprot IDs		B4DM50 Q9Y3A3	B1AUU8 B7Z240 H7BYP0 P42566
PDB IDs			1C07 1EH2 1F8H 1FF1 2IV9 2JXC
Enriched GO Terms of Interacting Partners?		Developmental Process Anatomical Structure Development Cell Differentiation Positive Regulation Of Protein Metabolic Process Multicellular Organismal Development Regulation Of Metabolic Process Regulation Of Cellular Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cellular Metabolic Process Hippo Signaling Regulation Of Protein Metabolic Process Regulation Of Neuron Projection Development Signal Transduction Positive Regulation Of Neuron Projection Development System Development Cellular Response To Stimulus Regulation Of Cellular Component Organization Generation Of Neurons Regulation Of Cellular Protein Metabolic Process Signaling Neurogenesis Regulation Of Phosphorylation Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cell Projection Organization Regulation Of Cell Projection Organization Cell Communication Regulation Of Protein Kinase Activity Regulation Of Protein Phosphorylation Regulation Of Kinase Activity Regulation Of Neuron Differentiation Positive Regulation Of Neuron Differentiation Neuron Projection Development Regulation Of Phosphorus Metabolic Process Cellular Response To Organic Substance Nervous System Development Cell Projection Organization Regulation Of Signal Transduction Cell Projection Morphogenesis Response To Stimulus Positive Regulation Of Catalytic Activity Cellular Response To Growth Factor Stimulus Positive Regulation Of Cell Differentiation Positive Regulation Of Phosphorylation Cell Part Morphogenesis Regulation Of Nitrogen Compound Metabolic Process Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Cell Death	Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Endocytosis Vesicle-mediated Transport Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Protein K48-linked Ubiquitination Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Signal Transduction Protein Polyubiquitination Negative Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Signaling Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Signaling Cell Communication Transport Post-Golgi Vesicle-mediated Transport Cellular Localization Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Neuron Development Neurotrophin TRK Receptor Signaling Pathway Neuron Projection Development Establishment Of Localization In Cell Neuron Projection Morphogenesis Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Neurotrophin Signaling Pathway Intracellular Transport Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Neuron Differentiation Cell Surface Receptor Signaling Pathway Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Cellular Response To Growth Factor Stimulus Establishment Of Protein Localization Response To Growth Factor Regulation Of Intracellular Signal Transduction Ephrin Receptor Signaling Pathway Protein Modification By Small Protein Conjugation Cellular Response To Hypoxia Protein Monoubiquitination Protein Catabolic Process Cellular Response To Decreased Oxygen Levels Receptor Internalization Protein Targeting To Lysosome
Tagcloud ?			6g4 adaptin adaptins ap cerevisiae clathrin coimmunoprecipitated delineated end3 endocytosis glutathione homology immunoprecipitates immunoreactivity kd keeping mammals metabolically mu2 nh2 nih3t3 pheromone polypeptides precipitated saccharomyces sets sigma transferase ubiquitous
Tagcloud (Difference) ?			6g4 adaptin adaptins ap cerevisiae clathrin coimmunoprecipitated delineated end3 endocytosis glutathione homology immunoprecipitates immunoreactivity kd keeping mammals metabolically mu2 nh2 nih3t3 pheromone polypeptides precipitated saccharomyces sets sigma transferase ubiquitous
Tagcloud (Intersection) ?