MOB4 and KIDINS220

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		MOB4	KIDINS220
Description		MOB family member 4, phocein	kinase D interacting substrate 220
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Membrane Golgi Cisterna Membrane Perinuclear Region Of Cytoplasm FAR/SIN/STRIPAK Complex Postsynapse Glutamatergic Synapse	Endosome Late Endosome Cytosol Membrane Protein-containing Complex
	Molecular Function	Protein Binding Protein-macromolecule Adaptor Activity Metal Ion Binding	Protein Binding Protein Kinase Regulator Activity PDZ Domain Binding
	Biological Process	Negative Regulation Of Hippo Signaling	In Utero Embryonic Development Nervous System Development Positive Regulation Of Neuron Projection Development Nerve Growth Factor Signaling Pathway Dendrite Morphogenesis Cellular Response To Nerve Growth Factor Stimulus
Pathways			ARMS-mediated activation ARMS-mediated activation RND2 GTPase cycle RND1 GTPase cycle
Drugs
Diseases
GWAS		Allergic rhinitis ( 31361310) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Schizophrenia ( 29483656) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Alcoholic chronic pancreatitis ( 28754779) Femur bone mineral density x serum urate levels interaction ( 34046847) HDL cholesterol levels ( 32109663) Neutrophil count ( 21507922) Skin aging measurement ( 31522824) Waist-hip ratio ( 28552196)
Interacting Genes		32 interacting genes: ARHGEF15 CCDC85B CRMP1 DNM1 EGFR EGLN2 ELK1 EPS15 FADD FBLN1 GDF9 KIDINS220 LATS1 LATS2 LRIF1 MAP4K4 MCM2 MED10 MED31 MYL6 MYO9B NME2 PAICS PLEKHM1 PTPRS RAPGEF2 SCMH1 SETDB1 STK11 STK3 THAP4 UBE2V2	12 interacting genes: CDC73 CRKL FHL3 KRT34 MOB4 MYC NGFR NTRK1 NTRK2 NTRK3 PRKD1 SEPTIN5
Entrez ID		25843	57498
HPRD ID		10165	17235
Ensembl ID		ENSG00000115540	ENSG00000134313
Uniprot IDs		Q9Y3A3	A0A8I5QJC0 Q9ULH0
PDB IDs		5YF4 7K36
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Hippo Signaling Hippo Signaling Regulation Of Growth Regulation Of Hippo Signaling Regulation Of Cell Junction Assembly Inner Cell Mass Cell Fate Commitment Inner Cell Mass Cellular Morphogenesis ATP Binding Nucleotide Binding Negative Regulation Of Growth Regulation Of Macromolecule Metabolic Process Regulation Of Protein Phosphorylation Regulation Of Cellular Component Organization Regulation Of Cell Growth Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Postsynapse Organization Kinase Activity Regulation Of Phosphorylation Negative Regulation Of Canonical Wnt Signaling Pathway Transcription Regulator Activator Activity Negative Regulation Of Cyclin-dependent Protein Kinase Activity Regulation Of Protein Modification Process Cell Surface Receptor Signaling Pathway Regulation Of Synapse Assembly Developmental Process Endocytic Vesicle Clathrin-coated Pit Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of Wnt Signaling Pathway Protein Kinase Activity Regulation Of Intracellular Signal Transduction Regulation Of Metabolic Process Negative Regulation Of Cell Growth Positive Regulation Of DNA-templated Transcription Initiation Establishment Of Endothelial Intestinal Barrier Negative Regulation Of Wnt Signaling Pathway Nerve Growth Factor Signaling Pathway DNA Replication Origin Binding Regulation Of Postsynaptic Density Assembly Positive Regulation Of Cellular Component Biogenesis Protein-containing Complex Assembly Protein Phosphorylation Positive Regulation Of Apoptotic Process Regulation Of DNA-templated Transcription Initiation Protein Serine Kinase Activity Clathrin Coat Assembly Positive Regulation Of Programmed Cell Death Regulation Of Postsynaptic Specialization Assembly	Neurotrophin Binding Neurotrophin Receptor Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Response To Growth Factor Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cell Communication Regulation Of Signaling Neurotrophin Signaling Pathway Mechanoreceptor Differentiation Cellular Response To Growth Factor Stimulus Cell Surface Receptor Signaling Pathway Circadian Rhythm Cellular Developmental Process Positive Regulation Of Neuron Projection Development Cellular Response To Nerve Growth Factor Stimulus Regulation Of Signal Transduction Response To Nerve Growth Factor Nerve Growth Factor Binding Regulation Of Cell Population Proliferation Positive Regulation Of Intracellular Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Activity Regulation Of Neuron Projection Development GPI-linked Ephrin Receptor Activity Positive Regulation Of Synapse Assembly Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Oxygen-containing Compound Apoptotic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Population Proliferation Postsynaptic Specialization Assembly Regulation Of Apoptotic Process Regulation Of Multicellular Organismal Development Action Potential Propagation Neuronal Action Potential Propagation Cell Death Programmed Cell Death Rhythmic Process B Cell Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Programmed Cell Death Regulation Of Fibroblast Proliferation Nervous System Development System Development Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Developmental Process Positive Regulation Of Cell Junction Assembly Regulation Of Plasma Membrane Bounded Cell Projection Organization
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