HIST1H2BA and SET

Number of citations of the paper that reports this interaction (PMID 19358706)
1

Data Source:
BioGRID (pull down)

		HIST1H2BA	SET
Gene Name		histone cluster 1, H2ba	SET nuclear proto-oncogene
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleosome Nucleus Nucleoplasm Extrinsic Component Of Plasma Membrane	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol Protein Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Molecular_function DNA Binding Protein Heterodimerization Activity	DNA Binding Protein Phosphatase Inhibitor Activity Protein Binding Protein Phosphatase Type 2A Regulator Activity Histone Binding
	Biological Process	Chromatin Organization Nucleosome Assembly Nucleosome Disassembly Inflammatory Response Plasminogen Activation Spermatogenesis, Exchange Of Chromosomal Proteins Positive Regulation Of Binding Mononuclear Cell Migration	Mitotic Cell Cycle DNA Replication Nucleosome Assembly Nucleosome Disassembly Nucleocytoplasmic Transport Gene Expression Negative Regulation Of Histone Acetylation Negative Regulation Of Catalytic Activity Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Catalytic Activity
Pathways		RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mitotic Prophase Regulatory RNA pathways RNA Polymerase I Promoter Clearance Deposition of new CENPA-containing nucleosomes at the centromere Cellular Senescence Signaling by Wnt HATs acetylate histones M Phase Amyloids NoRC negatively regulates rRNA expression Packaging Of Telomere Ends Telomere Maintenance Nucleosome assembly RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN DNA methylation Transcriptional regulation by small RNAs Meiotic recombination DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance Chromatin organization HDACs deacetylate histones misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling RNA Polymerase I Transcription formation of the beta-catenin:TCF transactivating complex Meiotic synapsis Epigenetic regulation of gene expression Senescence-Associated Secretory Phenotype (SASP) Negative epigenetic regulation of rRNA expression PRC2 methylates histones and DNA Cell Cycle, Mitotic Chromatin modifying enzymes Oxidative Stress Induced Senescence TCF dependent signaling in response to WNT RNA Polymerase I Promoter Opening SIRT1 negatively regulates rRNA Expression Signaling by WNT in cancer Condensation of Prophase Chromosomes	Regulation of mRNA stability by proteins that bind AU-rich elements Mitotic Prophase Condensation of Prophase Chromosomes HuR stabilizes mRNA Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS			Eating disorders (purging via substances) ( 23568457)
Protein-Protein Interactions		6 interactors: APP CCNA1 DNTTIP2 HIST2H2AC PARP1 SET	51 interactors: ANP32A APEX1 APP CALM1 CDK5 CDK5R1 CDKN1A CHAF1A CHRM2 CHRM3 ELAVL1 ELF4 EP300 FAM111B FOS GZMA GZMK HDAC1 HIST1H2BA HIST1H3A HIST2H4A HIST3H3 HIST4H4 HMGB2 IRF1 JUNB KLF5 KMT2A MDM2 MEOX2 MTERF1 NME1 NUCB1 NUPR1 PIK3CG PPP2CA PPP2R1B PRKAR1A PTMA RAC1 SDCBP SETBP1 SGOL1 TAF1A TERF1 TERF2 TERF2IP THAP7 TP53 TREX1 UCHL5
Entrez ID		255626	6418
HPRD ID		11024	09023
Ensembl ID		ENSG00000146047	ENSG00000119335
Uniprot IDs		Q96A08	Q01105 Q5VXV3
PDB IDs			2E50
Enriched GO Terms of Interacting Partners?		Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Regulation Of Growth Rate Protein Poly-ADP-ribosylation Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of RNA Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Regulation Of Binding Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process DNA Damage Response, Detection Of DNA Damage Positive Regulation Of Transcription Regulatory Region DNA Binding Neuron Remodeling Protein Autoprocessing Positive Regulation Of SMAD Protein Import Into Nucleus Nucleosome Disassembly Regulation Of Cellular Amino Acid Metabolic Process Regulation Of SMAD Protein Import Into Nucleus Regulation Of Mitotic Cell Cycle Response To Oxidative Stress Cellular Copper Ion Homeostasis Macrophage Differentiation Gene Expression Negative Regulation Of Histone Acetylation Cellular Response To Superoxide Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Copper Ion Homeostasis Suckling Behavior Negative Regulation Of Peptidyl-lysine Acetylation Regulation Of Cell Cycle Process Negative Regulation Of Protein Acetylation Regulation Of Transcription Regulatory Region DNA Binding Regulation Of Cellular Ketone Metabolic Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Response To Superoxide Protein ADP-ribosylation Response To Oxygen Radical Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Regulation Of Transcription From RNA Polymerase II Promoter	Negative Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process DNA Metabolic Process Regulation Of Cell Cycle Cellular Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Nitrogen Compound Metabolic Process Regulation Of Gene Expression Chromosome Organization Regulation Of Transcription, DNA-templated Cell Death Death Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Gene Expression Telomere Maintenance Developmental Process Regulation Of RNA Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Apoptotic Process Programmed Cell Death Regulation Of Cell Cycle Process Cellular Metabolic Process DNA Replication-dependent Nucleosome Assembly Cell Cycle Transcription, DNA-templated Organelle Organization Regulation Of Gene Expression, Epigenetic Blood Coagulation Positive Regulation Of Protein Metabolic Process Chromatin Assembly RNA Biosynthetic Process Cellular Component Assembly Hemostasis Chromatin Organization Negative Regulation Of Cell Cycle Anatomical Structure Development Cellular Response To Growth Factor Stimulus Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Body Fluid Levels Negative Regulation Of Transcription, DNA-templated Response To Growth Factor Negative Regulation Of Gene Expression
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