H2BC1 and USP44

Number of citations of the paper that reports this interaction (PubMedID 27880911)
61

Data Source:
BioGRID (enzymatic study)

		H2BC1	USP44
Description		H2B clustered histone 1	ubiquitin specific peptidase 44
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleosome Female Germ Cell Nucleus Nucleus Nucleoplasm Chromosome Cell Surface	Chromatin Nucleus Nucleoplasm Cytoplasm Mitotic Spindle
	Molecular Function	DNA Binding Structural Constituent Of Chromatin Histone Binding Protein Heterodimerization Activity	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding Deubiquitinase Activity
	Biological Process	Chromatin Organization Nucleosome Assembly Nucleosome Disassembly Inflammatory Response Plasminogen Activation Sperm DNA Condensation Chromosome Organization Mononuclear Cell Migration	Immune System Process Nucleotide-excision Repair Proteolysis Chromosome Segregation Regulation Of Cell Cycle Process Protein Deubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulatory T Cell Differentiation Innate Immune Response Negative Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Mitotic Metaphase/anaphase Transition Cell Division Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Antiviral Innate Immune Response Negative Regulation Of Ubiquitin Protein Ligase Activity
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence HDACs deacetylate histones HATs acetylate histones HATs acetylate histones SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Ub-specific processing proteases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Deposition of new CENPA-containing nucleosomes at the centromere Assembly of the ORC complex at the origin of replication G2/M DNA damage checkpoint RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape E3 ubiquitin ligases ubiquitinate target proteins RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Inhibition of DNA recombination at telomere Defective pyroptosis Negative Regulation of CDH1 Gene Transcription Amyloid fiber formation Chromatin modifications during the maternal to zygotic transition (MZT) Replacement of protamines by nucleosomes in the male pronucleus MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Regulation of PD-L1(CD274) transcription	Ub-specific processing proteases
Drugs
Diseases
GWAS			Brain volume in infants (white matter) ( 28763065) Breast size ( 27182965) C-reactive protein levels ( 30388399) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Response to anti-depressant treatment in major depressive disorder ( 22041458) Type 2 diabetes ( 30297969)
Interacting Genes		9 interacting genes: ANP32B APP CCNA1 DNTTIP2 H2AC20 HDAC3 SET UBE2B USP44	1 interacting genes: H2BC1
Entrez ID		255626	84101
HPRD ID		11024	15636
Ensembl ID		ENSG00000146047	ENSG00000136014
Uniprot IDs		Q96A08	F8VRI7 Q9H0E7
PDB IDs		3WKJ 5GSU 5GT3 6BIY 8VLR
Enriched GO Terms of Interacting Partners?		Chromatin Organization Chromatin Remodeling Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Neuron Apoptotic Process Positive Regulation Of Establishment Of Protein Localization Epigenetic Regulation Of Gene Expression Regulation Of Response To Calcium Ion Regulation Of Multicellular Organism Growth Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Cell Cycle Regulation Of Programmed Cell Death Nucleus Positive Regulation Of Protein Transport Regulation Of Post-translational Protein Modification Regulation Of Protein Export From Nucleus Positive Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Ferroptosis Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Apoptotic Process Acetylcholine Receptor Activator Activity Negative Regulation Of Metabolic Process Lipoprotein Particle Positive Regulation Of Protein Import Nucleoplasm Negative Regulation Of Programmed Cell Death Negative Regulation Of Post-translational Protein Modification Positive Regulation Of Reciprocal Meiotic Recombination Protein De-2-hydroxyisobutyrylase Activity Positive Regulation Of Intracellular Protein Transport Cyclin A1-CDK1 Complex Cyclin A1-CDK2 Complex PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Interleukin-1 Production Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Protein Transport Chromatin Binding Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Localization Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Regulation Of Cell Cycle Nucleosome Assembly	Nucleosome Disassembly Protein-DNA Complex Disassembly Sperm DNA Condensation Female Germ Cell Nucleus Plasminogen Activation Zymogen Activation Nucleosome Histone Binding Nucleosome Assembly Protein-containing Complex Disassembly Protein-DNA Complex Assembly Protein Processing Chromosome, Telomeric Region Mononuclear Cell Migration Nucleosome Organization Structural Constituent Of Chromatin Leukocyte Migration Protein Maturation Protein Heterodimerization Activity Chromosome Organization
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