H2BC1 and UBE2B

Number of citations of the paper that reports this interaction (PubMedID 36162503)
114

Data Source:
BioGRID (enzymatic study)

		H2BC1	UBE2B
Description		H2B clustered histone 1	ubiquitin conjugating enzyme E2 B
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleosome Female Germ Cell Nucleus Nucleus Nucleoplasm Chromosome Cell Surface	Chromatin XY Body Nucleus Nucleoplasm Replication Fork Cytoplasm Plasma Membrane Membrane HULC Complex
	Molecular Function	DNA Binding Structural Constituent Of Chromatin Histone Binding Protein Heterodimerization Activity	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Conjugating Enzyme Activity
	Biological Process	Chromatin Organization Nucleosome Assembly Nucleosome Disassembly Inflammatory Response Plasminogen Activation Sperm DNA Condensation Chromosome Organization Mononuclear Cell Migration	Protein Polyubiquitination In Utero Embryonic Development DNA Repair Postreplication Repair Chromatin Organization Ubiquitin-dependent Protein Catabolic Process Apoptotic Process DNA Damage Response Spermatogenesis Sperm Axoneme Assembly Response To Xenobiotic Stimulus Response To UV Positive Regulation Of Reciprocal Meiotic Recombination Protein Ubiquitination Ectopic Germ Cell Programmed Cell Death Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Meiotic Telomere Clustering Protein Stabilization Chiasma Assembly Negative Regulation Of Developmental Process Protein Autoubiquitination Synaptonemal Complex Organization Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Post-translational Protein Modification Negative Regulation Of Reproductive Process
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence HDACs deacetylate histones HATs acetylate histones HATs acetylate histones SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Ub-specific processing proteases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Deposition of new CENPA-containing nucleosomes at the centromere Assembly of the ORC complex at the origin of replication G2/M DNA damage checkpoint RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape E3 ubiquitin ligases ubiquitinate target proteins RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Inhibition of DNA recombination at telomere Defective pyroptosis Negative Regulation of CDH1 Gene Transcription Amyloid fiber formation Chromatin modifications during the maternal to zygotic transition (MZT) Replacement of protamines by nucleosomes in the male pronucleus MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Regulation of PD-L1(CD274) transcription	Recognition of DNA damage by PCNA-containing replication complex Synthesis of active ubiquitin: roles of E1 and E2 enzymes E3 ubiquitin ligases ubiquitinate target proteins Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Relative amplitude of rest-activity cycles ( 30120083)
Interacting Genes		9 interacting genes: ANP32B APP CCNA1 DNTTIP2 H2AC20 HDAC3 SET UBE2B USP44	29 interacting genes: BIRC2 CBX5 CDKN1B CNOT4 CRMP1 CTNNB1 H2AC20 H2BC1 HERPUD2 MED31 PCNA PRKN RAD18 RC3H1 RC3H2 RNF167 RNF20 RNF4 RNF40 TRIM14 TRIM45 UBA1 UBA6 UBR1 UBR2 UBR3 UBR4 UBR5 UNC119
Entrez ID		255626	7320
HPRD ID		11024	01533
Ensembl ID		ENSG00000146047	ENSG00000119048
Uniprot IDs		Q96A08	P63146
PDB IDs		3WKJ 5GSU 5GT3 6BIY 8VLR	1JAS 2Y4W 2YB6 2YBF
Enriched GO Terms of Interacting Partners?		Chromatin Organization Chromatin Remodeling Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Neuron Apoptotic Process Positive Regulation Of Establishment Of Protein Localization Epigenetic Regulation Of Gene Expression Regulation Of Response To Calcium Ion Regulation Of Multicellular Organism Growth Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Cell Cycle Regulation Of Programmed Cell Death Nucleus Positive Regulation Of Protein Transport Regulation Of Post-translational Protein Modification Regulation Of Protein Export From Nucleus Positive Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Ferroptosis Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Apoptotic Process Acetylcholine Receptor Activator Activity Negative Regulation Of Metabolic Process Lipoprotein Particle Positive Regulation Of Protein Import Nucleoplasm Negative Regulation Of Programmed Cell Death Negative Regulation Of Post-translational Protein Modification Positive Regulation Of Reciprocal Meiotic Recombination Protein De-2-hydroxyisobutyrylase Activity Positive Regulation Of Intracellular Protein Transport Cyclin A1-CDK1 Complex Cyclin A1-CDK2 Complex PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Interleukin-1 Production Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Protein Transport Chromatin Binding Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Localization Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Regulation Of Cell Cycle Nucleosome Assembly	Ubiquitin Protein Ligase Activity Protein Ubiquitination Post-translational Protein Modification Protein Modification By Small Protein Conjugation Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Modification Process Proteolysis Macromolecule Catabolic Process Ubiquitin-protein Transferase Activity Protein Polyubiquitination Catabolic Process Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Via The N-end Rule Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin Ligase Complex Zinc Ion Binding Transferase Activity Proteasomal Protein Catabolic Process Macromolecule Metabolic Process Protein Catabolic Process Protein K11-linked Ubiquitination Protein K48-linked Ubiquitination Protein K29-linked Ubiquitination Metal Ion Binding Cellular Response To Stress Protein Autoubiquitination Protein K63-linked Ubiquitination Ubiquitin Activating Enzyme Activity Cytoplasm Protein Quality Control By The Ubiquitin-proteasome System Ubiquitin Protein Ligase Binding Protein K6-linked Ubiquitination Response To Stress Cytoplasm Protein Quality Control Protein-containing Complex Binding HULC Complex DNA Damage Response Response To Amino Acid Positive Regulation Of Metabolic Process Placenta Development L-leucine Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Organization Positive Regulation Of Macromolecule Metabolic Process Epithelial Cell Proliferation Involved In Prostate Gland Development Limb Development Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Ubiquitin-like Modifier Activating Enzyme Activity T Follicular Helper Cell Differentiation
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