ALOX5 and MEOX1

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		ALOX5	MEOX1
Gene Name		arachidonate 5-lipoxygenase	mesenchyme homeobox 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Nuclear Envelope Nuclear Envelope Lumen Cytosol Nuclear Matrix Nuclear Membrane	Nucleus Cytoplasm
	Molecular Function	Arachidonate 5-lipoxygenase Activity Iron Ion Binding Protein Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Core Promoter Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Molecular_function Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Sequence-specific DNA Binding HMG Box Domain Binding
	Biological Process	Leukotriene Production Involved In Inflammatory Response Leukotriene Metabolic Process Arachidonic Acid Metabolic Process Leukotriene Biosynthetic Process Lipoxygenase Pathway Small Molecule Metabolic Process Oxidation-reduction Process Lipoxin Metabolic Process	Somite Specification Transcription, DNA-templated Multicellular Organismal Development Biological_process Positive Regulation Of Transcription From RNA Polymerase II Promoter Hematopoietic Stem Cell Differentiation Somite Development Sclerotome Development
Pathways		Arachidonic acid metabolism Synthesis of 5-eicosatetraenoic acids Metabolism of lipids and lipoproteins Synthesis of Lipoxins (LX) Synthesis of Leukotrienes (LT) and Eoxins (EX)
Drugs		Vitamin E Masoprocol Aminosalicylic Acid Mesalazine Montelukast Diclofenac Diethylcarbamazine Zileuton Sulfasalazine Meclofenamic acid Balsalazide Minocycline Hyperforin Heme
Diseases
GWAS		Mean corpuscular hemoglobin ( 20139978) Mean corpuscular volume ( 20139978)
Protein-Protein Interactions		17 interactors: ACTB ALOX5AP APP CEP57L1 CEP63 COTL1 DICER1 GRB2 HHIPL2 LTC4S MAD1L1 MAPKAPK2 MEOX1 NUTM1 REL SYCE1 TGFBRAP1	28 interactors: ALOX5 APP APPL1 CIAO1 CIB3 CKS1B CWF19L2 CYFIP1 DCX FMR1 MAPK9 MID1 MORF4L1 MVP NAGK NEIL2 PAGE3 PARK2 PAX1 PAX3 QRICH1 RANBP3 SOX10 SYT17 TCEANC TXLNA UBE2R2 UBXN2B
Entrez ID		240	4222
HPRD ID		01065	02537
Ensembl ID		ENSG00000012779	ENSG00000005102
Uniprot IDs		E5FPY5 E5FPY8 P09917	P50221
PDB IDs		2ABV 3O8Y 3V92 3V98 3V99
Enriched GO Terms of Interacting Partners?		Leukotriene Metabolic Process Lipoxin Metabolic Process Arachidonic Acid Metabolic Process Defense Response Lipoxygenase Pathway Icosanoid Metabolic Process Unsaturated Fatty Acid Metabolic Process Long-chain Fatty Acid Metabolic Process Leukotriene Biosynthetic Process Cellular Component Assembly MRNA Stabilization Innate Immune Response Cell Division Immune System Process Platelet Activation Cell Cycle Process Cell Cycle Checkpoint Icosanoid Biosynthetic Process Wound Healing Regulation Of MRNA Stability Unsaturated Fatty Acid Biosynthetic Process Regulation Of RNA Stability Neuron Projection Morphogenesis Conversion Of Ds SiRNA To Ss SiRNA Involved In RNA Interference Regulation Of Metaphase Plate Congression Hair Follicle Cell Proliferation Conversion Of Ds SiRNA To Ss SiRNA Positive Regulation Of Metabolic Process Response To External Stimulus Endocytosis Response To Stress Response To Wounding Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Fatty Acid Metabolic Process Immune Response Microtubule-based Process Regulation Of ERBB Signaling Pathway Regulation Of Enamel Mineralization Peripheral Nervous System Myelin Formation Synaptic Growth At Neuromuscular Junction Zygote Asymmetric Cell Division Spindle Assembly Cell Cycle Neuron Projection Development Signal Transduction In Response To DNA Damage Cell Projection Morphogenesis Vesicle-mediated Transport Targeting Of MRNA For Destruction Involved In RNA Interference Collateral Sprouting In Absence Of Injury Axon Guidance	Cell Proliferation Central Nervous System Development Developmental Cell Growth Developmental Growth Developmental Growth Involved In Morphogenesis Cell Growth Protein K48-linked Ubiquitination Protein Monoubiquitination Axon Extension Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Leukotriene Production Involved In Inflammatory Response Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Mitochondrial Fusion Neural Crest Cell Migration Mesenchyme Development Growth Cellular Macromolecule Catabolic Process Regulation Of Protein Tyrosine Kinase Activity Nervous System Development Regulation Of Phosphorylation Base-excision Repair Neuron Projection Extension Synaptic Growth At Neuromuscular Junction Positive Regulation Of Protein Linear Polyubiquitination N-acetylmannosamine Metabolic Process Positive Regulation Of Transcription, DNA-templated Developmental Pigmentation Neural Crest Cell Development Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Proteasomal Protein Catabolic Process Protein Localization To Mitochondrion Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Dopamine Depurination Dopamine Uptake Involved In Synaptic Transmission Collateral Sprouting In Absence Of Injury Neural Crest Cell Differentiation Cognition Positive Regulation Of Proteolysis Regulation Of Phosphorus Metabolic Process
Tagcloud ?		af4 calcitriol conversely deacetylase derivatives deriving elongation encodes hdac hdac1 hdaci inactive lineage lipoxygenase mll overwrites physiologically portion relieving smad3 smad4 surprisingly switch transcriptionally transforming trichostatin trimethylation tsa
Tagcloud (Difference) ?		af4 calcitriol conversely deacetylase derivatives deriving elongation encodes hdac hdac1 hdaci inactive lineage lipoxygenase mll overwrites physiologically portion relieving smad3 smad4 surprisingly switch transcriptionally transforming trichostatin trimethylation tsa
Tagcloud (Intersection) ?