ALOX5 and HSD17B1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ALOX5	HSD17B1
Description		arachidonate 5-lipoxygenase	hydroxysteroid 17-beta dehydrogenase 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Nuclear Envelope Nuclear Envelope Lumen Nucleoplasm Cytoplasm Cytosol Membrane Nuclear Matrix Nuclear Membrane Secretory Granule Lumen Perinuclear Region Of Cytoplasm Ficolin-1-rich Granule Lumen	Cytoplasm Cytosol
	Molecular Function	Arachidonate 5-lipoxygenase Activity Arachidonate 12(S)-lipoxygenase Activity Iron Ion Binding Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen Hydrolase Activity Arachidonate 8(S)-lipoxygenase Activity Metal Ion Binding Dioxygenase Activity	Catalytic Activity Estradiol 17-beta-dehydrogenase [NAD(P)+] Activity Steroid Binding Protein Binding Oxidoreductase Activity Small Molecule Binding Protein Homodimerization Activity Testosterone Dehydrogenase (NAD+) Activity Testosterone Dehydrogenase (NADP+) Activity NADP Binding NADP+ Binding 17-beta-hydroxysteroid Dehydrogenase (NADP+) Activity Estradiol Binding
	Biological Process	Long-chain Fatty Acid Metabolic Process Negative Regulation Of Endothelial Cell Proliferation Leukocyte Chemotaxis Involved In Inflammatory Response Leukocyte Migration Involved In Inflammatory Response Leukotriene Production Involved In Inflammatory Response Lipid Metabolic Process Icosanoid Metabolic Process Leukotriene Metabolic Process Response To Stress Inflammatory Response Humoral Immune Response Negative Regulation Of Angiogenesis Arachidonate Metabolic Process Leukotriene Biosynthetic Process Lipoxygenase Pathway Positive Regulation Of Bone Mineralization Lipid Oxidation Dendritic Cell Migration Glucose Homeostasis Long-chain Fatty Acid Biosynthetic Process Regulation Of Fat Cell Differentiation Regulation Of Inflammatory Response Negative Regulation Of Inflammatory Response Regulation Of Insulin Secretion Negative Regulation Of Vascular Wound Healing Negative Regulation Of Wound Healing Regulation Of Inflammatory Response To Wounding Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Cellular Response To Oxidative Stress Leukotriene A4 Biosynthetic Process Regulation Of Reactive Oxygen Species Biosynthetic Process Negative Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Sprouting Angiogenesis Positive Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell Lipoxin Biosynthetic Process	Lipid Metabolic Process Steroid Biosynthetic Process Estrogen Biosynthetic Process Lysosome Organization Skeletal Muscle Tissue Development Estrogen Metabolic Process Gene Expression Bone Development Adipose Tissue Development Testosterone Biosynthetic Process Cellular Response To Metal Ion
Pathways		Synthesis of 5-eicosatetraenoic acids Synthesis of Leukotrienes (LT) and Eoxins (EX) Biosynthesis of Lipoxins (LX) Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation Interleukin-18 signaling Biosynthesis of D-series resolvins Biosynthesis of maresins Biosynthesis of E-series 18(S)-resolvins Biosynthesis of aspirin-triggered D-series resolvins Biosynthesis of E-series 18(R)-resolvins Biosynthesis of DPAn-3-derived protectins and resolvins Biosynthesis of DPAn-3-derived maresins Biosynthesis of DPAn-3-derived 13-series resolvins Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives	Estrogen biosynthesis The canonical retinoid cycle in rods (twilight vision)
Drugs		Icosapent Vitamin E Masoprocol Aminosalicylic acid Mesalazine Montelukast Diethylcarbamazine Zileuton Sulfasalazine Meclofenamic acid Balsalazide Minocycline Hyperforin Resveratrol Licofelone MLN-977 Morniflumate Diacerein Fostamatinib Rhein alpha-Tocopherol succinate D-alpha-Tocopherol acetate	NADH Androstenedione Androstanedione Equilin EM-1745 Stanolone Nicotinamide adenine dinucleotide phosphate Stanolone acetate
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Cholesterol, total ( 24097068) HDL cholesterol ( 24097068) HDL cholesterol levels ( 28334899) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin ( 20139978 32888494) Mean corpuscular volume ( 20139978) Total cholesterol levels ( 28334899)	Eczema ( 31361310) Parkinson's disease ( 27182965) Pulse pressure ( 28135244 30578418)
Interacting Genes		27 interacting genes: ACTB ALOX5AP ALPL APP C10orf67 CCDC174 CEP57L1 CEP63 COTL1 DICER1 GATC GRB2 HHIPL2 HSD17B1 LCN1 LTC4S MAD1L1 MAPKAPK2 MEOX1 MEOX2 MTDH NUTM1 OOEP REL SYCE1 TBC1D7 TGFBRAP1	2 interacting genes: ALOX5 PTEN
Entrez ID		240	3292
HPRD ID		01065	00185
Ensembl ID		ENSG00000012779	ENSG00000108786
Uniprot IDs		P09917	A0A0A0MQS7 P14061
PDB IDs		3O8Y 3V92 3V98 3V99 6N2W 6NCF 7TTJ 7TTK 7TTL	1A27 1BHS 1DHT 1EQU 1FDS 1FDT 1FDU 1FDV 1FDW 1I5R 1IOL 1JTV 1QYV 1QYW 1QYX 3DEY 3DHE 3HB4 3HB5 3KLM 3KLP 3KM0 6CGC 6CGE 6DTP 6MNC 6MNE 7X3Z
Enriched GO Terms of Interacting Partners?		Leukotriene Metabolic Process Leukotriene-C4 Synthase Activity Somite Specification Embryonic Pattern Specification	Lipid Modification Regulation Of Wound Healing Regulation Of Response To Wounding Leukotriene A4 Biosynthetic Process Arachidonate 5-lipoxygenase Activity Negative Regulation Of Wound Healing Negative Regulation Of Synaptic Vesicle Clustering Leukotriene A4 Metabolic Process Leukotriene Production Involved In Inflammatory Response Arachidonate 8(S)-lipoxygenase Activity Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Lipoxin Biosynthetic Process Arachidonate 12(S)-lipoxygenase Activity Positive Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission Arachidonate Metabolite Production Involved In Inflammatory Response Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell Epoxide Metabolic Process Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Myelin Sheath Adaxonal Region Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Phosphatidylinositol Phosphate Phosphatase Activity Regulation Of Synaptic Vesicle Clustering Negative Regulation Of Vascular Wound Healing Negative Regulation Of Peptidyl-serine Phosphorylation Postsynaptic Density Assembly Lipid Biosynthetic Process Leukocyte Chemotaxis Involved In Inflammatory Response Neuron-neuron Synaptic Transmission Negative Regulation Of Cell Size Anaphase-promoting Complex Binding Forebrain Morphogenesis Presynaptic Membrane Assembly Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen Lipoxygenase Pathway Regulation Of Inflammatory Response To Wounding Nuclear Envelope Lumen Production Of Molecular Mediator Involved In Inflammatory Response Locomotor Rhythm Cellular Response To Electrical Stimulus Ubiquitin Ligase Activator Activity Spindle Assembly Involved In Female Meiosis Postsynaptic Specialization Assembly Maternal Behavior Presynaptic Membrane Organization
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?