ALOX5 and LCN1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ALOX5	LCN1
Description		arachidonate 5-lipoxygenase	lipocalin 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Nuclear Envelope Nuclear Envelope Lumen Nucleoplasm Cytoplasm Cytosol Membrane Nuclear Matrix Nuclear Membrane Secretory Granule Lumen Perinuclear Region Of Cytoplasm Ficolin-1-rich Granule Lumen	Extracellular Region Extracellular Space
	Molecular Function	Arachidonate 5-lipoxygenase Activity Arachidonate 12(S)-lipoxygenase Activity Iron Ion Binding Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen Hydrolase Activity Arachidonate 8(S)-lipoxygenase Activity Metal Ion Binding Dioxygenase Activity	Cysteine-type Endopeptidase Inhibitor Activity Signaling Receptor Binding Protein Binding Zinc Ion Binding Chloride Ion Binding Small Molecule Binding
	Biological Process	Long-chain Fatty Acid Metabolic Process Negative Regulation Of Endothelial Cell Proliferation Leukocyte Chemotaxis Involved In Inflammatory Response Leukocyte Migration Involved In Inflammatory Response Leukotriene Production Involved In Inflammatory Response Lipid Metabolic Process Icosanoid Metabolic Process Leukotriene Metabolic Process Response To Stress Inflammatory Response Humoral Immune Response Negative Regulation Of Angiogenesis Arachidonate Metabolic Process Leukotriene Biosynthetic Process Lipoxygenase Pathway Positive Regulation Of Bone Mineralization Lipid Oxidation Dendritic Cell Migration Glucose Homeostasis Long-chain Fatty Acid Biosynthetic Process Regulation Of Fat Cell Differentiation Regulation Of Inflammatory Response Negative Regulation Of Inflammatory Response Regulation Of Insulin Secretion Negative Regulation Of Vascular Wound Healing Negative Regulation Of Wound Healing Regulation Of Inflammatory Response To Wounding Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Cellular Response To Oxidative Stress Leukotriene A4 Biosynthetic Process Regulation Of Reactive Oxygen Species Biosynthetic Process Negative Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Sprouting Angiogenesis Positive Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell Lipoxin Biosynthetic Process	Proteolysis Sensory Perception Of Taste
Pathways		Synthesis of 5-eicosatetraenoic acids Synthesis of Leukotrienes (LT) and Eoxins (EX) Biosynthesis of Lipoxins (LX) Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation Interleukin-18 signaling Biosynthesis of D-series resolvins Biosynthesis of maresins Biosynthesis of E-series 18(S)-resolvins Biosynthesis of aspirin-triggered D-series resolvins Biosynthesis of E-series 18(R)-resolvins Biosynthesis of DPAn-3-derived protectins and resolvins Biosynthesis of DPAn-3-derived maresins Biosynthesis of DPAn-3-derived 13-series resolvins Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives	Transport of fatty acids
Drugs		Icosapent Vitamin E Masoprocol Aminosalicylic acid Mesalazine Montelukast Diethylcarbamazine Zileuton Sulfasalazine Meclofenamic acid Balsalazide Minocycline Hyperforin Resveratrol Licofelone MLN-977 Morniflumate Diacerein Fostamatinib Rhein alpha-Tocopherol succinate D-alpha-Tocopherol acetate	Tretinoin
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Cholesterol, total ( 24097068) HDL cholesterol ( 24097068) HDL cholesterol levels ( 28334899) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin ( 20139978 32888494) Mean corpuscular volume ( 20139978) Total cholesterol levels ( 28334899)	Subcutaneous adipose tissue ( 29178545) Subcutaneous adipose tissue (sex interaction) ( 29178545)
Interacting Genes		27 interacting genes: ACTB ALOX5AP ALPL APP C10orf67 CCDC174 CEP57L1 CEP63 COTL1 DICER1 GATC GRB2 HHIPL2 HSD17B1 LCN1 LTC4S MAD1L1 MAPKAPK2 MEOX1 MEOX2 MTDH NUTM1 OOEP REL SYCE1 TBC1D7 TGFBRAP1	9 interacting genes: ALOX5 FAM25A FAM25C FAM25G LMBR1L LTF LYZ RECK UBQLN2
Entrez ID		240	3933
HPRD ID		01065	01059
Ensembl ID		ENSG00000012779	ENSG00000160349
Uniprot IDs		P09917	P31025
PDB IDs		3O8Y 3V92 3V98 3V99 6N2W 6NCF 7TTJ 7TTK 7TTL	1XKI 3EYC 4QAF 5T43
Enriched GO Terms of Interacting Partners?		Leukotriene Metabolic Process Leukotriene-C4 Synthase Activity Somite Specification Embryonic Pattern Specification	Leukotriene A4 Metabolic Process Regulation Of Response To Endoplasmic Reticulum Stress Leukotriene Production Involved In Inflammatory Response Leukotriene A4 Biosynthetic Process Regulation Of Bone Mineralization Arachidonate 5-lipoxygenase Activity Humoral Immune Response Arachidonate 8(S)-lipoxygenase Activity Positive Regulation Of Ossification Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Specific Granule Lumen Negative Regulation Of Single-species Biofilm Formation In Or On Host Organism Tertiary Granule Lumen Defense Response To Gram-negative Bacterium Negative Regulation Of Tumor Necrosis Factor (ligand) Superfamily Member 11 Production Negative Regulation Of G Protein-coupled Receptor Internalization Regulation Of Ossification Arachidonate Metabolite Production Involved In Inflammatory Response Lipoxin Biosynthetic Process Arachidonate 12(S)-lipoxygenase Activity Iron Ion Binding Positive Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen Phagocytic Vesicle Lumen Defense Response To Gram-positive Bacterium Positive Regulation Of Bone Mineralization Involved In Bone Maturation Killing Of Cells Of Another Organism Membrane Destabilizing Activity Regulation Of Establishment Of Blood-brain Barrier Negative Regulation Of Clathrin-dependent Endocytosis Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell Epoxide Metabolic Process Negative Regulation Of Osteoclast Development Antimicrobial Humoral Response Negative Regulation Of Vascular Wound Healing Lysozyme Activity Blood Vessel Maturation Leukocyte Chemotaxis Involved In Inflammatory Response Cell Killing Positive Regulation Of Chondrocyte Proliferation Regulation Of Osteoclast Development
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?