MEOX1 and CACNB3

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		MEOX1	CACNB3
Name		mesenchyme homeobox 1	calcium voltage-gated channel auxiliary subunit beta 3
Structure		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Cytoplasm	Cytoplasm Cytosol Voltage-gated Calcium Channel Complex Membrane Monoatomic Ion Channel Complex Synapse L-type Voltage-gated Calcium Channel Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding HMG Box Domain Binding Sequence-specific Double-stranded DNA Binding	Voltage-gated Calcium Channel Activity Calcium Channel Regulator Activity Calcium Channel Activity Protein Binding High Voltage-gated Calcium Channel Activity
	Biological Process	Somite Specification Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Hematopoietic Stem Cell Differentiation Somite Development Sclerotome Development	Monoatomic Ion Transport Calcium Ion Transport Chemical Synaptic Transmission Monoatomic Ion Transmembrane Transport T Cell Receptor Signaling Pathway Calcium Ion Transport Into Cytosol Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Calcium Ion Transmembrane Transport Protein Localization To Plasma Membrane Regulation Of Membrane Repolarization During Action Potential Positive Regulation Of High Voltage-gated Calcium Channel Activity
Pathways		None	Presynaptic depolarization and calcium channel opening Adrenaline,noradrenaline inhibits insulin secretion NCAM1 interactions Regulation of insulin secretion Regulation of insulin secretion Mechanical load activates signaling by PIEZO1 and integrins in osteocytes
Drugs		None	Ergocalciferol Enflurane Ranolazine Phenytoin Topiramate Nimodipine Spironolactone Nicardipine Magnesium sulfate Verapamil Levomenthol Nitrendipine Miconazole Amiodarone Mibefradil Dronedarone Nilvadipine Drotaverine Trimebutine Benidipine Cilnidipine Efonidipine Efonidipine Lacidipine Manidipine Butamben Bioallethrin Bioallethrin Fish oil
GWAS		Fractures ( 30158200 )	No GWAS studies recorded
Novel Interactors		None recorded	1 novel interactors: CDK2
Interacting Genes		99 interacting genes: ACBD4 ACOT12 AIRIM ALOX5 ANAPC2 APP APPL1 ATG9A BANP BNIP2 BYSL C14orf119 C1orf50 CACNB3 CATSPERT CCDC102B CDC34 CIAO1 CIB3 CIMIP4 CKS1B CNOT11 CSNK2A1 CWF19L2 CYFIP1 DCX DNAAF19 DUSP3 EIF4A3 EIF4EBP1 EMD FMR1 GCC1 GEMIN2 GPANK1 GYS1 HMBOX1 HMGB3 HOMER3 HOXC8 HYCC2 INPP5J KANK2 KCTD7 L3MBTL2 LMNA MAPK9 MBD3 MCRS1 MEF2A MID1 MID2 MKRN3 MLX MORF4L1 MVP NAGK NDOR1 NEIL2 OSGIN1 PAGE3 PARVG PAX1 PAX3 PCP2 PDE4C PELI2 PIN1 PLCD4 PM20D2 POLR3GL PPM1F PRKAG1 PRKN QRICH1 RAD52 RANBP3 RBM41 RBM5 SDCBP SEC14L4 SOX10 SPAG8 SPIC SYT17 TCEANC TCP11L1 TRAPPC2L TRIM41 TRIML2 TRIP10 TXLNA TXNL4B UBE2R2 UBXN2B UBXN7 UNC45A ZCCHC10 ZNF410	11 interacting genes: CACNA1B CACNA1C CEP76 CIMIP1 CTBP2 FASLG GEM MEOX1 MTUS2 SKIC2 SYT1
Entrez ID		4222	784
HPRD ID		02537	11879
Ensembl ID		ENSG00000005102	ENSG00000167535
Uniprot IDs		P50221	P54284
PDB IDs		Not available	7MIX 7MIY 7UHF 7UHG 8E59 8E5A 8E5B 8EPL 8FHS 8WE6 8WE7 8WE8 8WE9 8X90 8X91 8X93
GO Terms Enriched among Interactors		Protein Binding Cytosol Nucleoplasm Cytoplasm Growth Cone Filopodium Spindle Pole Centrosome Translation Repressor Activity Regulation Of Translation At Postsynapse, Modulating Synaptic Transmission Identical Protein Binding Perinuclear Region Of Cytoplasm Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Translation At Postsynapse	Positive Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Positive Regulation Of Synaptic Vesicle Exocytosis Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Calcium Ion Transmembrane Import Into Cytosol High Voltage-gated Calcium Channel Activity Positive Regulation Of Calcium Ion-dependent Exocytosis Positive Regulation Of Neurotransmitter Secretion Calcium Ion Import Across Plasma Membrane Calcium Ion Import Into Cytosol Voltage-gated Calcium Channel Complex Voltage-gated Calcium Channel Activity Calcium Ion Import Calcium Ion Transmembrane Transport Calmodulin Binding Regulation Of Calcium Ion-dependent Exocytosis Metal Ion Transport Calcium Ion Transport Positive Regulation Of Regulated Secretory Pathway Regulation Of Synaptic Vesicle Exocytosis Fast, Calcium Ion-dependent Exocytosis Of Neurotransmitter Synchronous Neurotransmitter Secretion Cell Communication Monoatomic Cation Transport Retinal Cell Programmed Cell Death Positive Regulation Of Phosphatidylserine Exposure On Apoptotic Cell Surface Calcium Channel Activity Regulation Of Neurotransmitter Secretion Positive Regulation Of Exocytosis Inorganic Cation Import Across Plasma Membrane Membrane Depolarization During Atrial Cardiac Muscle Cell Action Potential Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Voltage-gated Calcium Channel Activity Involved In AV Node Cell Action Potential Voltage-gated Calcium Channel Activity Involved In Cardiac Muscle Cell Action Potential Positive Regulation Of Chromatin Organization Y Chromosome Positive Regulation Of Heterochromatin Formation Cyclin A1-CDK2 Complex Cyclin-dependent Protein Kinase Activity Cyclin A2-CDK2 Complex Cyclin E1-CDK2 Complex Cyclin E2-CDK2 Complex Positive Regulation Of DNA-templated DNA Replication Initiation Sclerotome Development Ski Complex Nuclear-transcribed MRNA Catabolic Process, 3'-5' Exonucleolytic Nonsense-mediated Decay Clathrin-sculpted Acetylcholine Transport Vesicle Membrane Syntaxin-3 Binding Cytoplasmic Vesicle Lumen Monoatomic Ion Transport X Chromosome