ALOX5 and TGFBRAP1

Number of citations of the paper that reports this interaction (PubMedID 10051563)
26

Data Source:
HPRD (in vivo)

		ALOX5	TGFBRAP1
Description		arachidonate 5-lipoxygenase	transforming growth factor beta receptor associated protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Nuclear Envelope Nuclear Envelope Lumen Nucleoplasm Cytoplasm Cytosol Membrane Nuclear Matrix Nuclear Membrane Secretory Granule Lumen Perinuclear Region Of Cytoplasm Ficolin-1-rich Granule Lumen	Cytoplasm Endosome Early Endosome Endomembrane System Membrane CORVET Complex
	Molecular Function	Arachidonate 5-lipoxygenase Activity Arachidonate 12(S)-lipoxygenase Activity Iron Ion Binding Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen Hydrolase Activity Arachidonate 8(S)-lipoxygenase Activity Metal Ion Binding Dioxygenase Activity	Transforming Growth Factor Beta Receptor Binding Protein Binding SMAD Binding
	Biological Process	Long-chain Fatty Acid Metabolic Process Negative Regulation Of Endothelial Cell Proliferation Leukocyte Chemotaxis Involved In Inflammatory Response Leukocyte Migration Involved In Inflammatory Response Leukotriene Production Involved In Inflammatory Response Lipid Metabolic Process Icosanoid Metabolic Process Leukotriene Metabolic Process Response To Stress Inflammatory Response Humoral Immune Response Negative Regulation Of Angiogenesis Arachidonate Metabolic Process Leukotriene Biosynthetic Process Lipoxygenase Pathway Positive Regulation Of Bone Mineralization Lipid Oxidation Dendritic Cell Migration Glucose Homeostasis Long-chain Fatty Acid Biosynthetic Process Regulation Of Fat Cell Differentiation Regulation Of Inflammatory Response Negative Regulation Of Inflammatory Response Regulation Of Insulin Secretion Negative Regulation Of Vascular Wound Healing Negative Regulation Of Wound Healing Regulation Of Inflammatory Response To Wounding Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Cellular Response To Oxidative Stress Leukotriene A4 Biosynthetic Process Regulation Of Reactive Oxygen Species Biosynthetic Process Negative Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Sprouting Angiogenesis Positive Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell Lipoxin Biosynthetic Process	Regulation Of DNA-templated Transcription Intracellular Protein Transport Autophagy Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Endosome To Lysosome Transport Protein Transport Vesicle-mediated Transport Endosomal Vesicle Fusion Regulation Of SNARE Complex Assembly
Pathways		Synthesis of 5-eicosatetraenoic acids Synthesis of Leukotrienes (LT) and Eoxins (EX) Biosynthesis of Lipoxins (LX) Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation Interleukin-18 signaling Biosynthesis of D-series resolvins Biosynthesis of maresins Biosynthesis of E-series 18(S)-resolvins Biosynthesis of aspirin-triggered D-series resolvins Biosynthesis of E-series 18(R)-resolvins Biosynthesis of DPAn-3-derived protectins and resolvins Biosynthesis of DPAn-3-derived maresins Biosynthesis of DPAn-3-derived 13-series resolvins Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives
Drugs		Icosapent Vitamin E Masoprocol Aminosalicylic acid Mesalazine Montelukast Diethylcarbamazine Zileuton Sulfasalazine Meclofenamic acid Balsalazide Minocycline Hyperforin Resveratrol Licofelone MLN-977 Morniflumate Diacerein Fostamatinib Rhein alpha-Tocopherol succinate D-alpha-Tocopherol acetate
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Cholesterol, total ( 24097068) HDL cholesterol ( 24097068) HDL cholesterol levels ( 28334899) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin ( 20139978 32888494) Mean corpuscular volume ( 20139978) Total cholesterol levels ( 28334899)	AIDS ( 19754311) Body mass index ( 26426971) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Gut microbiota relative abundance (Coprococcus) ( 33208821) Menarche (age at onset) ( 27182965) Obesity-related traits ( 23251661) Preeclampsia ( 23551011) Walking pace ( 33128006)
Interacting Genes		27 interacting genes: ACTB ALOX5AP ALPL APP C10orf67 CCDC174 CEP57L1 CEP63 COTL1 DICER1 GATC GRB2 HHIPL2 HSD17B1 LCN1 LTC4S MAD1L1 MAPKAPK2 MEOX1 MEOX2 MTDH NUTM1 OOEP REL SYCE1 TBC1D7 TGFBRAP1	9 interacting genes: ACVR1B ACVR2B ACVRL1 ALOX5 BMPR1A SMAD2 SMAD4 TGFBR1 TGFBR2
Entrez ID		240	9392
HPRD ID		01065	06948
Ensembl ID		ENSG00000012779	ENSG00000135966
Uniprot IDs		P09917	Q8WUH2
PDB IDs		3O8Y 3V92 3V98 3V99 6N2W 6NCF 7TTJ 7TTK 7TTL
Enriched GO Terms of Interacting Partners?		Leukotriene Metabolic Process Leukotriene-C4 Synthase Activity Somite Specification Embryonic Pattern Specification	Transmembrane Receptor Protein Serine/threonine Kinase Activity Activin Receptor Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway SMAD Binding Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Activin Binding Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Response To Growth Factor Roof Of Mouth Development Activin Receptor Complex Activin Receptor Activity, Type I Transforming Growth Factor Beta Receptor Signaling Pathway In Utero Embryonic Development Chordate Embryonic Development Positive Regulation Of SMAD Protein Signal Transduction Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Cellular Response To Growth Factor Stimulus I-SMAD Binding Enzyme-linked Receptor Protein Signaling Pathway Regulation Of SMAD Protein Signal Transduction Endocardial Cushion Morphogenesis Positive Regulation Of Developmental Process Transforming Growth Factor Beta Receptor Activity, Type I Positive Regulation Of Cell Differentiation Heart Development Regionalization Negative Regulation Of Developmental Process Regulation Of Cell Differentiation Regulation Of Ossification Trophoblast Cell Migration Ventricular Septum Morphogenesis Positive Regulation Of Multicellular Organismal Process Transforming Growth Factor Beta Receptor Activity Gastrulation Anterior/posterior Pattern Specification Mesoderm Development Protein Serine/threonine Kinase Activity Pattern Specification Process Positive Regulation Of Epithelial To Mesenchymal Transition Cell Surface Receptor Signaling Pathway Tissue Morphogenesis Artery Morphogenesis Secondary Palate Development Embryonic Morphogenesis Receptor Complex Anatomical Structure Formation Involved In Morphogenesis Response To Transforming Growth Factor Beta Cardiac Septum Morphogenesis
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