ALOX5 and REL

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		ALOX5	REL
Gene Name		arachidonate 5-lipoxygenase	v-rel avian reticuloendotheliosis viral oncogene homolog
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Nuclear Envelope Nuclear Envelope Lumen Cytosol Nuclear Matrix Nuclear Membrane	Nucleoplasm Transcription Factor Complex Cytosol I-kappaB/NF-kappaB Complex
	Molecular Function	Arachidonate 5-lipoxygenase Activity Iron Ion Binding Protein Binding	RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding
	Biological Process	Leukotriene Production Involved In Inflammatory Response Leukotriene Metabolic Process Arachidonic Acid Metabolic Process Leukotriene Biosynthetic Process Lipoxygenase Pathway Small Molecule Metabolic Process Oxidation-reduction Process Lipoxin Metabolic Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Cytokine Production Transcription, DNA-templated Inflammatory Response I-kappaB Kinase/NF-kappaB Signaling Response To Cytokine NIK/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Interleukin-12 Biosynthetic Process Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Neuron Death
Pathways		Arachidonic acid metabolism Synthesis of 5-eicosatetraenoic acids Metabolism of lipids and lipoproteins Synthesis of Lipoxins (LX) Synthesis of Leukotrienes (LT) and Eoxins (EX)	Signaling by the B Cell Receptor (BCR) Downstream signaling events of B Cell Receptor (BCR) Activation of NF-kappaB in B cells Adaptive Immune System
Drugs		Vitamin E Masoprocol Aminosalicylic Acid Mesalazine Montelukast Diclofenac Diethylcarbamazine Zileuton Sulfasalazine Meclofenamic acid Balsalazide Minocycline Hyperforin Heme
Diseases
GWAS		Mean corpuscular hemoglobin ( 20139978) Mean corpuscular volume ( 20139978)	Celiac disease ( 20190752) Crohn's disease ( 22412388 21102463) Hodgkin's lymphoma ( 21037568) Inflammatory bowel disease ( 23128233) Psoriasis ( 20953190) Psoriatic arthritis ( 22170493) Rheumatoid arthritis ( 20453842 19503088) Ulcerative colitis ( 20228799)
Protein-Protein Interactions		17 interactors: ACTB ALOX5AP APP CEP57L1 CEP63 COTL1 DICER1 GRB2 HHIPL2 LTC4S MAD1L1 MAPKAPK2 MEOX1 NUTM1 REL SYCE1 TGFBRAP1	201 interactors: A1CF AAAS ACOT8 ACTN3 ADRB2 ADSL AES AGPAT4 ALOX5 AR ARIH2 ARNT2 ASAP3 ATG9A ATPAF2 ATXN1 BARHL2 BID BMF BZRAP1 C11orf68 C12orf75 C1orf109 C20orf195 C9orf72 C9orf91 CABP5 CALM1 CCNE1 CCNJL CDKN2C CEP19 CGGBP1 CHAF1A CHCHD2 CIB3 CINP CKS1B CLIC4 COL20A1 COL8A1 CPNE2 CPSF1 CTNNBIP1 CXCL14 DAAM2 DGCR6 DHPS DMRT3 DNTT DPF2 DYNC1LI1 EFHC1 EGLN3 EIF3A EIF3D EIF4E2 EIF4EBP1 EIF5A EIF5A2 ELF1 EML2 EP300 EPHB6 EPM2AIP1 EXOSC1 EXOSC5 EXOSC8 FHIT FHL2 FKBP1B FLAD1 FLNA FOXO4 FUT11 GADD45G GLYCTK GRB2 GTF2B HAT1 HDAC7 HIP1 HLA-DOA HSPA4 HSPA8 HSPB7 IL36RN KIAA0100 KLHL32 KLHL40 KRTAP9-4 LASP1 LGALS14 LMO1 LMO2 LNPEP LSM2 MAD2L2 MAGOHB MAP3K7CL MAP3K8 MAPK8 MEMO1 MIEN1 MORF4L1 MRPL10 MTPN MVP NAGK NCK2 NDE1 NDUFAF3 NECAP1 NEDD9 NEIL2 NEUROG3 NFKB1 NFKB2 NFKBIA NFKBIB NFKBIE NGB NKRF NME7 NOL9 NOTCH1 NR2C2AP NUCB1 NUDT14 NXT2 OAZ3 OSGIN1 OSTF1 OTUB2 OTUD4 PARK2 PARVG PATE1 PIH1D2 PLCB4 PLEKHN1 POLE2 POLR1A POLR2L POP5 PPP4C PRDM10 PRKAB2 PSMA1 PTGER3 PTK6 R3HDM2 RAB41 RABIF RASSF5 RBM39 RECK RELA REXO1L6P RIPPLY1 RNF213 RSPH14 SAT1 SDCBP SEC14L4 SEC31A SEPT7 SIN3A SLC39A13 SLC41A3 SLC6A12 SNRNP25 SP1 SRF STK16 STRA13 SZT2 TBP TDO2 TMEM165 TMEM8A TNIP2 TNS2 TRAPPC2L TRIM74 TSSC4 TSSK3 TSTD2 TTC19 TTC21A TXNL4B UBASH3A UBE2K UBE2Z VPS25 ZDHHC24 ZNF417 ZNF550 ZNF564 ZNF572 ZNF765
Entrez ID		240	5966
HPRD ID		01065	01286
Ensembl ID		ENSG00000012779	ENSG00000162924
Uniprot IDs		E5FPY5 E5FPY8 P09917	Q04864 Q17RU2
PDB IDs		2ABV 3O8Y 3V92 3V98 3V99
Enriched GO Terms of Interacting Partners?		Leukotriene Metabolic Process Lipoxin Metabolic Process Arachidonic Acid Metabolic Process Defense Response Lipoxygenase Pathway Icosanoid Metabolic Process Unsaturated Fatty Acid Metabolic Process Long-chain Fatty Acid Metabolic Process Leukotriene Biosynthetic Process Cellular Component Assembly MRNA Stabilization Innate Immune Response Cell Division Immune System Process Platelet Activation Cell Cycle Process Cell Cycle Checkpoint Icosanoid Biosynthetic Process Wound Healing Regulation Of MRNA Stability Unsaturated Fatty Acid Biosynthetic Process Regulation Of RNA Stability Neuron Projection Morphogenesis Conversion Of Ds SiRNA To Ss SiRNA Involved In RNA Interference Regulation Of Metaphase Plate Congression Hair Follicle Cell Proliferation Conversion Of Ds SiRNA To Ss SiRNA Positive Regulation Of Metabolic Process Response To External Stimulus Endocytosis Response To Stress Response To Wounding Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Fatty Acid Metabolic Process Immune Response Microtubule-based Process Regulation Of ERBB Signaling Pathway Regulation Of Enamel Mineralization Peripheral Nervous System Myelin Formation Synaptic Growth At Neuromuscular Junction Zygote Asymmetric Cell Division Spindle Assembly Cell Cycle Neuron Projection Development Signal Transduction In Response To DNA Damage Cell Projection Morphogenesis Vesicle-mediated Transport Targeting Of MRNA For Destruction Involved In RNA Interference Collateral Sprouting In Absence Of Injury Axon Guidance	Gene Expression RNA Metabolic Process Macromolecule Biosynthetic Process Cellular Macromolecule Biosynthetic Process Transcription, DNA-templated RNA Biosynthetic Process Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Gene Expression Cellular Process Regulation Of Cellular Protein Metabolic Process Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Toll-like Receptor 2 Signaling Pathway Regulation Of Nitrogen Compound Metabolic Process Toll-like Receptor 9 Signaling Pathway Apoptotic Process Cell Death Toll-like Receptor 3 Signaling Pathway Death Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Programmed Cell Death Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Peptidyl-lysine Modification To Peptidyl-hypusine Positive Regulation Of Type I Interferon Production Regulation Of RNA Metabolic Process Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Posttranscriptional Regulation Of Gene Expression Cellular Response To Stimulus Negative Regulation Of Cellular Metabolic Process
Tagcloud ?		af4 calcitriol conversely deacetylase derivatives deriving elongation encodes hdac hdac1 hdaci inactive lineage lipoxygenase mll overwrites physiologically portion relieving smad3 smad4 surprisingly switch transcriptionally transforming trichostatin trimethylation tsa	chorionic commercial complementary crude deoxynucleotidyl deoxyuridine digoxigenin exhibiting fractions furthered go gonadotropin haf hcg immunodeficiency inoculation kaposi ks neoplastic nick preceded pregnancy preparations sarcoma slk transferase triphosphate tunel y
Tagcloud (Difference) ?		af4 calcitriol conversely deacetylase derivatives deriving elongation encodes hdac hdac1 hdaci inactive lineage lipoxygenase mll overwrites physiologically portion relieving smad3 smad4 surprisingly switch transcriptionally transforming trichostatin trimethylation tsa	chorionic commercial complementary crude deoxynucleotidyl deoxyuridine digoxigenin exhibiting fractions furthered go gonadotropin haf hcg immunodeficiency inoculation kaposi ks neoplastic nick preceded pregnancy preparations sarcoma slk transferase triphosphate tunel y
Tagcloud (Intersection) ?