MEOX1 and PDE4C

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MEOX1	PDE4C
Description		mesenchyme homeobox 1	phosphodiesterase 4C
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Cytoplasm	Extracellular Space Cytosol Cilium Cell Projection
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding HMG Box Domain Binding Sequence-specific Double-stranded DNA Binding	3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity Protein Binding Phosphoric Diester Hydrolase Activity Hydrolase Activity Metal Ion Binding 3',5'-cyclic-GMP Phosphodiesterase Activity
	Biological Process	Somite Specification Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Hematopoietic Stem Cell Differentiation Somite Development Sclerotome Development	CAMP Catabolic Process Signal Transduction Negative Regulation Of CAMP/PKA Signal Transduction
Pathways			DARPP-32 events G alpha (s) signalling events
Drugs			Caffeine Dyphylline Iloprost Amrinone Roflumilast Piclamilast Rolipram Crisaborole Ibudilast Exisulind Trapidil
Diseases
GWAS		Fractures ( 30158200)	A body shape index ( 34021172) Abdominal subcutaneous adipose tissue volume ( 34128465) Apolipoprotein B levels ( 32203549) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) Urate levels ( 31578528) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		99 interacting genes: ACBD4 ACOT12 AIRIM ALOX5 ANAPC2 APP APPL1 ATG9A BANP BNIP2 BYSL C14orf119 C1orf50 CACNB3 CATSPERT CCDC102B CDC34 CIAO1 CIB3 CIMIP4 CKS1B CNOT11 CSNK2A1 CWF19L2 CYFIP1 DCX DNAAF19 DUSP3 EIF4A3 EIF4EBP1 EMD FMR1 GCC1 GEMIN2 GPANK1 GYS1 HMBOX1 HMGB3 HOMER3 HOXC8 HYCC2 INPP5J KANK2 KCTD7 L3MBTL2 LMNA MAPK9 MBD3 MCRS1 MEF2A MID1 MID2 MKRN3 MLX MORF4L1 MVP NAGK NDOR1 NEIL2 OSGIN1 PAGE3 PARVG PAX1 PAX3 PCP2 PDE4C PELI2 PIN1 PLCD4 PM20D2 POLR3GL PPM1F PRKAG1 PRKN QRICH1 RAD52 RANBP3 RBM41 RBM5 SDCBP SEC14L4 SOX10 SPAG8 SPIC SYT17 TCEANC TCP11L1 TRAPPC2L TRIM41 TRIML2 TRIP10 TXLNA TXNL4B UBE2R2 UBXN2B UBXN7 UNC45A ZCCHC10 ZNF410	9 interacting genes: DDIT4L GSC2 KLRK1 MEOX1 MEOX2 OSGIN1 PAX6 SRI ZNF280A
Entrez ID		4222	5143
HPRD ID		02537	02529
Ensembl ID		ENSG00000005102	ENSG00000105650
Uniprot IDs		P50221	O43849 P78505 Q08493 Q32MM7 Q7KYS4
PDB IDs			2QYM
Enriched GO Terms of Interacting Partners?		Protein Binding Cytosol Nucleoplasm Cytoplasm Growth Cone Filopodium Spindle Pole Centrosome Translation Repressor Activity Regulation Of Translation At Postsynapse, Modulating Synaptic Transmission Identical Protein Binding Perinuclear Region Of Cytoplasm Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Translation At Postsynapse	Somite Specification Segment Specification HMG Box Domain Binding Somite Development Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Sequence-specific Double-stranded DNA Binding DNA-binding Transcription Factor Activity Embryonic Pattern Specification Forebrain-midbrain Boundary Formation Pancreatic A Cell Development Response To Metformin Negative Regulation Of Leukocyte Migration Negative Regulation Of Cell Migration Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Negative Regulation Of Natural Killer Cell Chemotaxis DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Pattern Specification Process Sclerotome Development Regulation Of Cell Migration Habenula Development Pallium Development Negative Regulation Of Lymphocyte Chemotaxis Regulation Of Cell Motility Chromatin Regulation Of Locomotion Regulation Of Asymmetric Cell Division Oligodendrocyte Cell Fate Specification
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