ALOX5 and MAD1L1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ALOX5	MAD1L1
Description		arachidonate 5-lipoxygenase	mitotic arrest deficient 1 like 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Nuclear Envelope Nuclear Envelope Lumen Nucleoplasm Cytoplasm Cytosol Membrane Nuclear Matrix Nuclear Membrane Secretory Granule Lumen Perinuclear Region Of Cytoplasm Ficolin-1-rich Granule Lumen	Chromosome, Centromeric Region Kinetochore Spindle Pole Nucleus Nuclear Envelope Chromosome Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Nuclear Pore Nuclear Basket Mitotic Spindle Mitotic Spindle Pole MAD1 Complex Mitotic Spindle Assembly Checkpoint MAD1-MAD2 Complex
	Molecular Function	Arachidonate 5-lipoxygenase Activity Arachidonate 12(S)-lipoxygenase Activity Iron Ion Binding Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen Hydrolase Activity Arachidonate 8(S)-lipoxygenase Activity Metal Ion Binding Dioxygenase Activity	Protein Binding Identical Protein Binding Kinetochore Binding
	Biological Process	Long-chain Fatty Acid Metabolic Process Negative Regulation Of Endothelial Cell Proliferation Leukocyte Chemotaxis Involved In Inflammatory Response Leukocyte Migration Involved In Inflammatory Response Leukotriene Production Involved In Inflammatory Response Lipid Metabolic Process Icosanoid Metabolic Process Leukotriene Metabolic Process Response To Stress Inflammatory Response Humoral Immune Response Negative Regulation Of Angiogenesis Arachidonate Metabolic Process Leukotriene Biosynthetic Process Lipoxygenase Pathway Positive Regulation Of Bone Mineralization Lipid Oxidation Dendritic Cell Migration Glucose Homeostasis Long-chain Fatty Acid Biosynthetic Process Regulation Of Fat Cell Differentiation Regulation Of Inflammatory Response Negative Regulation Of Inflammatory Response Regulation Of Insulin Secretion Negative Regulation Of Vascular Wound Healing Negative Regulation Of Wound Healing Regulation Of Inflammatory Response To Wounding Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Cellular Response To Oxidative Stress Leukotriene A4 Biosynthetic Process Regulation Of Reactive Oxygen Species Biosynthetic Process Negative Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Sprouting Angiogenesis Positive Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell Lipoxin Biosynthetic Process	Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of T Cell Proliferation Thymus Development Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore Regulation Of Metaphase Plate Congression Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Regulation Of Mitotic Cell Cycle Phase Transition Deactivation Of Mitotic Spindle Assembly Checkpoint
Pathways		Synthesis of 5-eicosatetraenoic acids Synthesis of Leukotrienes (LT) and Eoxins (EX) Biosynthesis of Lipoxins (LX) Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation Interleukin-18 signaling Biosynthesis of D-series resolvins Biosynthesis of maresins Biosynthesis of E-series 18(S)-resolvins Biosynthesis of aspirin-triggered D-series resolvins Biosynthesis of E-series 18(R)-resolvins Biosynthesis of DPAn-3-derived protectins and resolvins Biosynthesis of DPAn-3-derived maresins Biosynthesis of DPAn-3-derived 13-series resolvins Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs		Icosapent Vitamin E Masoprocol Aminosalicylic acid Mesalazine Montelukast Diethylcarbamazine Zileuton Sulfasalazine Meclofenamic acid Balsalazide Minocycline Hyperforin Resveratrol Licofelone MLN-977 Morniflumate Diacerein Fostamatinib Rhein alpha-Tocopherol succinate D-alpha-Tocopherol acetate
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Cholesterol, total ( 24097068) HDL cholesterol ( 24097068) HDL cholesterol levels ( 28334899) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin ( 20139978 32888494) Mean corpuscular volume ( 20139978) Total cholesterol levels ( 28334899)	Adult body size ( 32376654) Adverse response to drug ( 30420678) Age at first birth ( 34211149) Age at first sexual intercourse ( 34211149 27089180) Alcohol consumption (drinks per week) ( 30643258) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Anthropometric traits (multi-trait analysis) ( 30166351) Anxiety ( 31906708) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972 34002096 28115744 27329760) Bitter alcoholic beverage consumption ( 31046077) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Coronary artery disease ( 29212778 33020668) Dimensional psychopathology (Social) ( 29496196) Disruptive behavior disorder and attention deficit hyperactivity disorder ( 33495439) Gastroesophageal reflux disease ( 34187846 31527586) General factor of neuroticism ( 30867560) Gut microbiota relative abundance (Streptococcus) ( 33208821) Hand grip strength ( 29691431) Idiopathic pulmonary fibrosis ( 31710517) Longevity ( 20834067) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444 31624269) Myocardial infarction ( 33532862) Number of sexual partners ( 30643258) Platelet count ( 32888494) Plateletcrit ( 32888494) Prostate cancer ( 29892016) Prostate cancer (advanced) ( 29892016) Refractive error ( 32231278) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Risk-taking tendency (4-domain principal component model) ( 30643258) Rosacea symptom severity ( 29771307) Schizophrenia ( 30285260 22688191 28991256 23974872 29483656) Schizophrenia or bipolar disorder ( 24280982) Schizophrenia, schizoaffective disorder or bipolar disorder ( 24166486) Sepsis (28-day mortality) ( 32592749) Sleep duration (short sleep) ( 30846698) Smoking initiation ( 33082346) Smoking status (ever vs never smokers) ( 30643258) Superior frontal gyrus volume ( 31530798) Superior temporal gyrus volume ( 31530798) Systolic blood pressure ( 30578418) Testicular germ cell tumor ( 28604732 23666239 28604728) Vaginal microbiome composition (Shannon diversity index) ( 32723796)
Interacting Genes		27 interacting genes: ACTB ALOX5AP ALPL APP C10orf67 CCDC174 CEP57L1 CEP63 COTL1 DICER1 GATC GRB2 HHIPL2 HSD17B1 LCN1 LTC4S MAD1L1 MAPKAPK2 MEOX1 MEOX2 MTDH NUTM1 OOEP REL SYCE1 TBC1D7 TGFBRAP1	63 interacting genes: ALOX5 AMOTL2 ATG5 BIRC2 CAPN7 CCDC57 CCHCR1 CDC37 CDK18 CIMIP4 COIL CWF19L2 DRC4 FAM131C FAM90A1 FXR1 GPKOW HAUS1 HDAC1 HDAC2 KIF9 LENG1 LGALSL LMO1 LMO3 LNX1 MAD2L1 MAX MFAP1 MLX NDC80 NEBL NEK2 NINL NONO NTAQ1 PIBF1 PML PPP1R18 PSMA1 RNF8 SIN3A SIN3B SPATA18 SPATA2 SUPT5H SYT17 SYT6 TCAF1 TEX11 TPM1 TPM3 TPR TRIM29 TSC22D3 TSGA10 TSHZ3 TUBGCP4 UBC UBTF USP15 YJU2 ZSCAN32
Entrez ID		240	8379
HPRD ID		01065	04065
Ensembl ID		ENSG00000012779	ENSG00000002822
Uniprot IDs		P09917	Q9Y6D9
PDB IDs		3O8Y 3V92 3V98 3V99 6N2W 6NCF 7TTJ 7TTK 7TTL	1GO4 4DZO 7B1F 7B1H 7B1J
Enriched GO Terms of Interacting Partners?		Leukotriene Metabolic Process Leukotriene-C4 Synthase Activity Somite Specification Embryonic Pattern Specification	Cytoplasm Sin3-type Complex Nucleoplasm Protein Binding Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides Chromatin Binding Protein Lysine Delactylase Activity Fungiform Papilla Formation Positive Regulation Of Cell Cycle Checkpoint Spindle Assembly Nuclear Chromosome Segregation Protein Decrotonylase Activity Histone Decrotonylase Activity Muscle Thin Filament Tropomyosin Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Microtubule Cytoskeleton Organization Hair Follicle Placode Formation Negative Regulation Of Stem Cell Population Maintenance Membraneless Organelle Assembly Mitotic Spindle Assembly Checkpoint Signaling Regulation Of Mitotic Cell Cycle Cellular Response To Dopamine Negative Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Chromosome Organization Intracellular Membraneless Organelle Negative Regulation Of RNA Metabolic Process Response To Dopamine Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Mitotic Sister Chromatid Segregation Stress Fiber Centrosome Cytoskeleton Negative Regulation Of Mitotic Nuclear Division Sister Chromatid Segregation Histone Deacetylase Complex Histone Deacetylase Activity, Hydrolytic Mechanism Kinetochore Spindle Organization Podosome Nuclear Pore Complex Assembly Microtubule-based Process Regulation Of Defense Response Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Binding Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Stem Cell Population Maintenance Calcium-dependent Phospholipid Binding Protein Lysine Deacetylase Activity
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