MEOX1 and EIF4EBP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MEOX1	EIF4EBP1
Description		mesenchyme homeobox 1	eukaryotic translation initiation factor 4E binding protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Cytoplasm	Nucleus Cytoplasm Cytosol
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding HMG Box Domain Binding Sequence-specific Double-stranded DNA Binding	Protein Binding Eukaryotic Initiation Factor 4E Binding Translation Repressor Activity Translation Initiation Factor Binding
	Biological Process	Somite Specification Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Hematopoietic Stem Cell Differentiation Somite Development Sclerotome Development	G1/S Transition Of Mitotic Cell Cycle Regulation Of Translation Negative Regulation Of Translation TOR Signaling Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of Translational Initiation
Pathways			mTORC1-mediated signalling Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Drugs
Diseases
GWAS		Fractures ( 30158200)	Menopause (age at onset) ( 29773799)
Interacting Genes		99 interacting genes: ACBD4 ACOT12 AIRIM ALOX5 ANAPC2 APP APPL1 ATG9A BANP BNIP2 BYSL C14orf119 C1orf50 CACNB3 CATSPERT CCDC102B CDC34 CIAO1 CIB3 CIMIP4 CKS1B CNOT11 CSNK2A1 CWF19L2 CYFIP1 DCX DNAAF19 DUSP3 EIF4A3 EIF4EBP1 EMD FMR1 GCC1 GEMIN2 GPANK1 GYS1 HMBOX1 HMGB3 HOMER3 HOXC8 HYCC2 INPP5J KANK2 KCTD7 L3MBTL2 LMNA MAPK9 MBD3 MCRS1 MEF2A MID1 MID2 MKRN3 MLX MORF4L1 MVP NAGK NDOR1 NEIL2 OSGIN1 PAGE3 PARVG PAX1 PAX3 PCP2 PDE4C PELI2 PIN1 PLCD4 PM20D2 POLR3GL PPM1F PRKAG1 PRKN QRICH1 RAD52 RANBP3 RBM41 RBM5 SDCBP SEC14L4 SOX10 SPAG8 SPIC SYT17 TCEANC TCP11L1 TRAPPC2L TRIM41 TRIML2 TRIP10 TXLNA TXNL4B UBE2R2 UBXN2B UBXN7 UNC45A ZCCHC10 ZNF410	38 interacting genes: AKT1 ATM BUB1 CHTF8 CSNK2A1 CSNK2A2 DDIT4L EIF4E EIF4E1B EIF4E2 GSK3B IRAK4 LATS1 LMO2 LRRK2 MAPK1 MAPK14 MAPKAPK5 MEOX1 MLST8 MTOR MVD PICK1 POU6F2 PPP2CA PRKCA PRKDC PTPA REL RHEBL1 RICTOR RORC RPS6KA5 RPS6KB1 RPTOR STK3 TCF4 ZNF655
Entrez ID		4222	1978
HPRD ID		02537	03746
Ensembl ID		ENSG00000005102	ENSG00000187840
Uniprot IDs		P50221	Q13541
PDB IDs			1EJ4 1EJH 1WKW 2JGB 2JGC 2V8W 2V8X 2V8Y 3HXG 3HXI 3M93 3M94 3U7X 4UED 5BXV 5EKV 5NVN 5WBJ 6BCU 6BCX 8RCH 8RCK 8RCN
Enriched GO Terms of Interacting Partners?		Protein Binding Cytosol Nucleoplasm Cytoplasm Growth Cone Filopodium Spindle Pole Centrosome Translation Repressor Activity Regulation Of Translation At Postsynapse, Modulating Synaptic Transmission Identical Protein Binding Perinuclear Region Of Cytoplasm Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Translation At Postsynapse	Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase Activity Kinase Activity Intracellular Signal Transduction Protein Phosphorylation ATP Binding Phosphorylation TOR Signaling Nucleotide Binding Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Macromolecule Biosynthetic Process Intracellular Signaling Cassette Negative Regulation Of Catabolic Process Regulation Of Intracellular Signal Transduction Regulation Of TOR Signaling Regulation Of Translation Regulation Of Gene Expression TORC2 Signaling Positive Regulation Of Cellular Component Organization Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Growth Regulation Of Signal Transduction Post-transcriptional Regulation Of Gene Expression Regulation Of Autophagy Negative Regulation Of Signal Transduction Signal Transduction Regulation Of Cell Cycle Regulation Of Apoptotic Process Regulation Of Mitotic Cell Cycle Regulation Of Programmed Cell Death Positive Regulation Of Intracellular Signal Transduction Transferase Activity Negative Regulation Of Metabolic Process Negative Regulation Of Autophagy Positive Regulation Of Growth Cellular Response To Nutrient Levels TORC1 Signaling Response To Nutrient Levels Protein Metabolic Process Regulation Of TORC2 Signaling Positive Regulation Of Protein-containing Complex Assembly
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