BRD4 and COPS5

Number of citations of the paper that reports this interaction (PubMedID 27107012)
72

Data Source:
BioGRID (two hybrid)

		BRD4	COPS5
Description		bromodomain containing 4	COP9 signalosome subunit 5
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GO Annotations	Cellular Component	Chromatin Condensed Nuclear Chromosome Nucleus Nucleoplasm Chromosome	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Synaptic Vesicle COP9 Signalosome Cytoplasmic Vesicle Synapse Perinuclear Region Of Cytoplasm
	Molecular Function	Transcription Cis-regulatory Region Binding P53 Binding Chromatin Binding Transcription Coregulator Activity Transcription Coactivator Activity Protein Serine/threonine Kinase Activity Protein Binding RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Enzyme Binding Protein-macromolecule Adaptor Activity Histone Binding RNA Polymerase II C-terminal Domain Binding P-TEFb Complex Binding Histone H4 Reader Activity Histone H4K12ac Reader Activity Histone H4K5ac Reader Activity Histone H4K16ac Reader Activity Histone H4K8ac Reader Activity Histone H3K9ac Reader Activity Histone H3K27ac Reader Activity	Transcription Coactivator Activity Translation Initiation Factor Activity Protein Binding Peptidase Activity Metallopeptidase Activity Hydrolase Activity DeNEDDylase Activity Enzyme Binding Macrophage Migration Inhibitory Factor Binding Metal Ion Binding Metal-dependent Deubiquitinase Activity
	Biological Process	Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II DNA Damage Response Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of Canonical NF-kappaB Signal Transduction Host-mediated Suppression Of Viral Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Inflammatory Response Negative Regulation Of DNA Damage Checkpoint Positive Regulation Of T-helper 17 Cell Lineage Commitment	Protein Deneddylation Translation Translational Initiation Proteolysis Negative Regulation Of Apoptotic Process Post-translational Protein Modification Protein Neddylation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of JNK Cascade Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Cell Cycle Regulation Of IRE1-mediated Unfolded Protein Response Exosomal Secretion Regulation Of Protein Neddylation
Pathways		Potential therapeutics for SARS Regulation of PD-L1(CD274) transcription	DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation GSK3B-mediated proteasomal degradation of PD-L1(CD274)
Drugs
Diseases
GWAS		Immature fraction of reticulocytes ( 32888494) Mean reticulocyte volume ( 32888494) Platelet count ( 32888494) Red cell distribution width ( 32888494) Systolic blood pressure ( 30578418)
Interacting Genes		22 interacting genes: ASXL1 ASXL2 BRD9 C7orf25 C8orf33 CCNT1 CCNT2 CHFR CLDN1 COPS5 ELOB ELOC H3C14 H4C16 MESD PRPF40A RFC1 RFC4 TRIM55 TRIM63 USP17L2 VHL	113 interacting genes: APCS APP ARFGAP1 ATM ATRN BCL2L14 BCL3 BRD4 BRSK2 BRWD1 BTG3 CACNA1C CD274 CD93 CDKN1B CEBPA CENPT CFAP298 COPS2 COPS3 COPS4 COPS6 COPS7A COPS8 CUL1 CUL2 CUL4B CUL5 DDB1 DDO DSCAM ERN1 ERRFI1 ESR1 F2RL1 GATD3 GFER GFI1B GPS1 GRIK1 GTPBP3 HAND2 HIF1A HNF4A HNF4G HTR6 HUNK IKBKB ITGB2 JUN JUND LASP1 LCOR MAP2K2 MAP3K11 MAP3K3 MAP3K7 MAP4K3 MAP4K5 MAPK14 MAPRE1 MAX MDC1 MDM2 MEF2C MEF2D MIF MORC3 MSRA MTRES1 MYG1 NCOA1 NEDD8 NFKB1 NR4A2 NR4A3 OPRM1 PEA15 PGR PLAC8 PPARG PPOX PPP1CC PRDX2 PRKD1 PTGS2 PUM1 PUM2 RAD1 RAD9A RNF139 RORA S100A7 SHANK3 SHISA5 SIAH1 SMAD2 SMAD4 SMAD5 SPP1 SREBF2 STAMBPL1 SUMO3 TOP2A TP53 TTC3 TXN TYK2 UCHL1 VTN WDR4 WNK1 YWHAG
Entrez ID		23476	10987
HPRD ID		10574	06888
Ensembl ID		ENSG00000141867	ENSG00000121022
Uniprot IDs		O60885	A0A024R7W9 Q92905
PDB IDs		2I8N 2LSP 2MJV 2N3K 2NCZ 2ND0 2ND1 2NNU 2OSS 2OUO 2YEL 2YEM 3MXF 3P5O 3SVF 3SVG 3U5J 3U5K 3U5L 3UVW 3UVX 3UVY 3UW9 3ZYU 4A9L 4BJX 4BW1 4BW2 4BW3 4BW4 4C66 4C67 4CFK 4CFL 4CL9 4CLB 4DON 4E96 4F3I 4GPJ 4HBV 4HBW 4HBX 4HBY 4HXK 4HXL 4HXM 4HXN 4HXO 4HXP 4HXR 4HXS 4IOO 4IOQ 4IOR 4J0R 4J0S 4J3I 4KV1 4KV4 4LR6 4LRG 4LYI 4LYS 4LYW 4LZR 4LZS 4MEN 4MEO 4MEP 4MEQ 4MR3 4MR4 4NQM 4NR8 4NUC 4NUD 4NUE 4O70 4O71 4O72 4O74 4O75 4O76 4O77 4O78 4O7A 4O7B 4O7C 4O7E 4O7F 4OGI 4OGJ 4PCE 4PCI 4PS5 4QB3 4QR3 4QR4 4QR5 4QZS 4UIX 4UIY 4UIZ 4UYD 4WHW 4WIV 4X2I 4XY9 4XYA 4YH3 4YH4 4Z1Q 4Z1S 4Z93 4ZC9 4ZW1 5A5S 5A85 5ACY 5AD2 5AD3 5BT4 5CFW 5COI 5CP5 5CPE 5CQT 5CRM 5CRZ 5CS8 5CTL 5CY9 5D0C 5D24 5D25 5D26 5D3H 5D3J 5D3L 5D3N 5D3P 5D3R 5D3S 5D3T 5DLX 5DLZ 5DW2 5DX4 5E0R 5EGU 5EI4 5EIS 5F5Z 5F60 5F61 5F62 5F63 5FBX 5H21 5HCL 5HLS 5HM0 5HQ5 5HQ6 5HQ7 5I80 5I88 5IGK 5JWM 5KDH 5KHM 5KJ0 5KU3 5LJ1 5LJ2 5LRQ 5LUU 5M39 5M3A 5MKZ 5MLI 5N2M 5NNC 5NND 5NNE 5NNF 5NNG 5O97 5OVB 5OWM 5OWW 5S9P 5S9Q 5S9R 5T35 5TI2 5TI3 5TI4 5TI5 5TI6 5TI7 5U28 5U2C 5U2E 5U2F 5UEO 5UEP 5UEQ 5UER 5UES 5UET 5UEU 5UEV 5UEX 5UEY 5UEZ 5UF0 5ULA 5UOO 5UVS 5UVT 5UVU 5UVV 5UVW 5UVX 5UVY 5UVZ 5V67 5VBO 5VBP 5VOM 5VZS 5W55 5WA5 5WMA 5WMD 5WMG 5WUU 5XHY 5XI2 5XI3 5XI4 5Y1Y 5Y8C 5Y8W 5Y8Y 5Y8Z 5Y93 5Y94 5YOU 5YOV 5YQX 5Z1R 5Z1S 5Z1T 5Z5T 5Z5U 5Z5V 5Z8G 5Z8R 5Z8Z 5Z90 5Z9C 5Z9K 6AFR 6AJV 6AJW 6AJX 6AJY 6AJZ 6BN7 6BN8 6BN9 6BNB 6BNH 6BOY 6C7Q 6C7R 6CD4 6CD5 6CIS 6CIY 6CJ1 6CJ2 6CKR 6CKS 6CZU 6CZV 6DJC 6DL2 6DMJ 6DML 6DNE 6DUV 6E4A 6FFD 6FNX 6FO5 6FSY 6FT3 6FT4 6G0D 6G0E 6G0F 6G0G 6G0H 6G0O 6G0P 6G0Q 6G0R 6G0S 6HDQ 6HOV 6I7X 6I7Y 6IN1 6JI3 6JI4 6JI5 6JJ3 6JJ5 6JJ6 6JJB 6KEC 6KED 6KEE 6KEF 6KEG 6KEH 6KEI 6KEJ 6KEK 6KO2 6LG4 6LG5 6LG6 6LG7 6LG8 6LG9 6LIH 6LIM 6MAU 6MH1 6MH7 6MNL 6P05 6PRT 6PS9 6PSB 6Q3Y 6Q3Z 6RWJ 6S25 6S4B 6S6K 6SA2 6SA3 6SAH 6SAJ 6SB8 6SE4 6SIS 6SWN 6SWQ 6TPX 6TPY 6TPZ 6U0D 6U6K 6U6L 6U72 6U74 6U8G 6U8I 6U8M 6ULS 6ULV 6UVJ 6UVM 6UWU 6UWX 6V0U 6V1K 6V1L 6V1U 6VIW 6VIX 6VIZ 6VUB 6VUC 6VUF 6VUJ 6WGX 6WVX 6WW8 6X7B 6X7C 6X7D 6XUZ 6XV3 6XV7 6XVC 6YIN 6YQN 6YQO 6YQP 6YQZ 6Z7G 6Z7L 6Z7M 6ZB3 6ZCI 6ZED 6ZEL 6ZF9 7A9U 7AJN 7AQT 7AXR 7B1T 7C2Z 7C6P 7DHS 7EHW 7EHY 7EIG 7EIK 7EIL 7FH2 7JKW 7JKX 7JKY 7JKZ 7K6G 7K6H 7KHH 7KHL 7KO0 7L9M 7LA9 7LH8 7M16 7MCE 7MCF 7MLQ 7MLR 7MLS 7MR5 7MR6 7MR7 7MR8 7MR9 7MRA 7MRB 7O18 7OEO 7P6V 7P6W 7P6Y 7Q3F 7QDL 7R5B 7R9C 7REK 7REL 7REM 7RJO 7RJP 7RJQ 7RJR 7RMD 7RN2 7RUH 7RUI 7RXR 7RXS 7RXT 7T3F 7TUQ 7TV0 7UGF 7USJ 7USK 7UTY 7UZN 7V1U 7V2J 7W3D 7WJS 7WKY 7WL4 7WWZ 7X6T 7YL2 7YMG 7YQ9 7Z9W 7Z9Y 7ZA6 7ZA7 7ZA8 7ZA9 7ZAA 7ZAD 7ZAE 7ZAJ 7ZAQ 7ZAR 7ZAT 7ZE6 7ZE7 7ZEF 7ZEN 7ZFN 7ZFO 7ZFS 7ZFT 7ZFU 7ZFV 7ZFY 7ZFZ 7ZG1 7ZG2 7ZNT 8B5B 8B5C 8B96 8B98 8BDS 8BDT 8BDX 8BEB 8C11 8CKF 8CV4 8CV6 8DYR 8E17 8E3W 8EAD 8EWV 8FVK 8G46 8GPZ 8GQ0 8IBQ 8IDH 8K14 8OV6 8P9F 8P9G 8P9H 8P9I 8P9J 8P9K 8P9L 8PIQ 8PXA 8PXM 8PXN 8Q34 8QAL 8QAN 8QAP 8QAR 8R5H 8RQ9 8RWZ 8RX0 8V9F 8WIU 8WQO 8WXY 8WY3 8WY7 8WYP 8YMB 8YME 8YMF 8YMG 8YMH 8YMI 8ZM8 8ZMB 8ZMQ 9F1J 9F1K 9F1L 9F1M 9F1N 9FBY 9FWX 9FXP	4D10 4D18 4F7O 4WSN 5JOG 5JOH 5M5Q 6R6H 6R7F 6R7H 6R7I 8H38 8H3A 8H3F
Enriched GO Terms of Interacting Partners?		Elg1 RFC-like Complex Target-directed MiRNA Degradation Elongin Complex PR-DUB Complex DNA Replication Factor C Complex Post-translational Protein Modification Cyclin/CDK Positive Transcription Elongation Factor Complex 7SK SnRNA Binding DNA Clamp Loader Activity Protein Modification By Small Protein Conjugation Peroxisome Proliferator Activated Receptor Binding Positive Regulation Of Biosynthetic Process Nucleoplasm Cyclin-dependent Protein Serine/threonine Kinase Activator Activity MiRNA Catabolic Process Negative Regulation Of Post-transcriptional Gene Silencing By Regulatory NcRNA Negative Regulation Of MiRNA-mediated Gene Silencing Cul5-RING Ubiquitin Ligase Complex Host-mediated Activation Of Viral Transcription Cul2-RING Ubiquitin Ligase Complex Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway RNA Polymerase Binding Nucleus Positive Regulation Of Macromolecule Biosynthetic Process Protein Ubiquitination Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Elongation MiRNA Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of MiRNA-mediated Gene Silencing Regulation Of Post-transcriptional Gene Silencing Host-mediated Perturbation Of Viral Transcription Chromatin Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Transcription By RNA Polymerase II Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Interleukin-12 Receptor Activity Xenobiotic Transport Across Blood-nerve Barrier Host-mediated Activation Of Viral Process Regulation Of Macromolecule Biosynthetic Process Macromolecule Metabolic Process Macromolecule Biosynthetic Process Regulation Of Defense Response To Virus By Host Nucleobase-containing Compound Biosynthetic Process P-TEFb Complex	Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Cell Communication Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Signaling Regulation Of Primary Metabolic Process Cellular Response To Stress Positive Regulation Of Signal Transduction Nucleoplasm Positive Regulation Of Metabolic Process Protein Deneddylation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Protein Neddylation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Protein Neddylation Positive Regulation Of Macromolecule Metabolic Process Regulation Of Multicellular Organismal Process Transcription Coactivator Binding Positive Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription MAPK Cascade Protein Modification Process Response To Stress Apoptotic Process Negative Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Intracellular Signal Transduction Intracellular Signaling Cassette Programmed Cell Death Cell Death Transcription Regulator Complex Nucleus Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Protein Modification By Small Protein Conjugation Regulation Of Developmental Process Positive Regulation Of Multicellular Organismal Process DNA-binding Transcription Factor Activity Cellular Response To Oxygen-containing Compound Negative Regulation Of Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Differentiation Protein-containing Complex
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