BRD4 and CCNT2

Number of citations of the paper that reports this interaction (PMID 16109376)
220

Data Source:
HPRD (in vivo)

		BRD4	CCNT2
Gene Name		bromodomain containing 4	cyclin T2
Image
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Condensed Nuclear Chromosome Nucleus Nucleoplasm Chromosome Cytoplasm Positive Transcription Elongation Factor Complex B	Nucleus Nucleoplasm
	Molecular Function	P53 Binding DNA Binding Chromatin Binding Protein Binding Lysine-acetylated Histone Binding	Protein Kinase Binding
	Biological Process	Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Inner Cell Mass Cell Proliferation Chromatin Remodeling Transcription, DNA-templated Protein Phosphorylation Cellular Response To DNA Damage Stimulus Chromosome Segregation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Viral Process Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of DNA Binding Histone H4-K12 Acetylation Histone H3-K14 Acetylation Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Inflammatory Response Regulation Of Phosphorylation Of RNA Polymerase II C-terminal Domain Negative Regulation Of DNA Damage Checkpoint	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Cell Cycle Transforming Growth Factor Beta Receptor Signaling Pathway Gene Expression Viral Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Division
Pathways			Loss of Function of TGFBR2 in Cancer RNA Polymerase II Transcription HIV Infection SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 LBD Mutants in Cancer RNA Polymerase II Pre-transcription Events SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer HIV elongation arrest and recovery HIV Life Cycle Generic Transcription Pathway TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Late Phase of HIV Life Cycle Formation of RNA Pol II elongation complex Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer Pausing and recovery of HIV elongation Formation of HIV elongation complex in the absence of HIV Tat Transcription of the HIV genome SMAD4 MH2 Domain Mutants in Cancer RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS
Protein-Protein Interactions		18 interactors: C7orf25 C8orf33 CCNT1 CCNT2 CHFR CLDN1 HIST2H3C HIST2H4A HIST4H4 JMJD6 MESDC2 PRPF40A RFC1 RFC2 RFC3 RFC4 RFC5 TCERG1	6 interactors: BRD4 CDK9 HEXIM1 PKN1 RB1 SUPT5H
Entrez ID		23476	905
HPRD ID		10574	04839
Ensembl ID		ENSG00000141867	ENSG00000082258
Uniprot IDs		O60885	B4DH21 O60583
PDB IDs		2I8N 2LSP 2NNU 2OSS 2OUO 2YEL 2YEM 3MXF 3P5O 3SVF 3SVG 3U5J 3U5K 3U5L 3UVW 3UVX 3UVY 3UW9 3ZYU 4A9L 4BJX 4BW1 4BW2 4BW3 4BW4 4C66 4C67 4DON 4E96 4F3I 4GPJ 4HBV 4HBW 4HBX 4HBY 4HXK 4HXL 4HXM 4HXN 4HXO 4HXP 4HXR 4HXS 4IOO 4IOQ 4IOR 4J0R 4J0S 4KV1 4KV4 4LR6 4LRG 4MEN 4MEO 4MEP 4MEQ	2IVX
Enriched GO Terms of Interacting Partners?		Telomere Maintenance Nucleotide-excision Repair, DNA Gap Filling Telomere Maintenance Via Semi-conservative Replication Nuclear DNA Replication Telomere Maintenance Via Recombination Mitotic Recombination DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening Transcription-coupled Nucleotide-excision Repair Cell Cycle Nucleotide-excision Repair DNA-dependent DNA Replication Mitotic Cell Cycle Homeostatic Process DNA Methylation On Cytosine Chromosome Organization DNA Metabolic Process Nucleobase-containing Compound Metabolic Process Chromatin Silencing At RDNA Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process DNA Recombination Cellular Nitrogen Compound Metabolic Process DNA Replication Nitrogen Compound Metabolic Process Chromatin Silencing Histone Demethylation Protein Demethylation Histone H4-K20 Demethylation Negative Regulation Of Megakaryocyte Differentiation Organelle Organization DNA Methylation Demethylation Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Hematopoietic Progenitor Cell Differentiation DNA Replication-dependent Nucleosome Assembly DNA Modification Cellular Metabolic Process DNA Repair Cell Cycle Process Gene Silencing Cellular Homeostasis Regulation Of Megakaryocyte Differentiation Gene Expression Cell Division CENP-A Containing Nucleosome Assembly Cellular Macromolecule Biosynthetic Process Cellular Response To DNA Damage Stimulus Macromolecule Biosynthetic Process	Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Negative Regulation Of Cell Cycle Viral Process Chromatin Modification RNA Metabolic Process Chromatin Remodeling Gene Expression Chromatin Organization Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of DNA-templated Transcription, Elongation Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Cycle Regulation Of Transcription, DNA-templated Regulation Of Protein Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Chromosome Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Viral Transcription Nucleobase-containing Compound Metabolic Process Regulation Of Protein Phosphorylation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of DNA-templated Transcription, Elongation Biosynthetic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cell Cycle Phase Transition Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Transcription Elongation From RNA Polymerase II Promoter Regulation Of Viral Transcription Regulation Of Phosphorylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Viral Process Negative Regulation Of Biosynthetic Process Regulation Of Cell Cycle Process Nitrogen Compound Metabolic Process DNA-templated Transcription, Elongation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Replication Fork Arrest Positive Regulation Of Cellular Biosynthetic Process
Tagcloud ?		3d chip combining compensatory confirming consequently deprived downregulate driver enrichment estrogens everolimus feedback jq1 loops lted matrigel mediating mimic mtor myc ofmycby oncogenes otherwise resensitization signatures uncover upregulation xenograft
Tagcloud (Difference) ?		3d chip combining compensatory confirming consequently deprived downregulate driver enrichment estrogens everolimus feedback jq1 loops lted matrigel mediating mimic mtor myc ofmycby oncogenes otherwise resensitization signatures uncover upregulation xenograft
Tagcloud (Intersection) ?