BRD4 and RFC1

Number of citations of the paper that reports this interaction (PMID 12192049)
52

Data Source:
HPRD (in vivo, in vitro)

		BRD4	RFC1
Gene Name		bromodomain containing 4	replication factor C (activator 1) 1, 145kDa
Image
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Condensed Nuclear Chromosome Nucleus Nucleoplasm Chromosome Cytoplasm Positive Transcription Elongation Factor Complex B	Nucleus Nucleoplasm DNA Replication Factor C Complex Nucleolus Golgi Apparatus Cell Junction Extracellular Vesicular Exosome
	Molecular Function	P53 Binding DNA Binding Chromatin Binding Protein Binding Lysine-acetylated Histone Binding	DNA Binding DNA Clamp Loader Activity Double-stranded DNA Binding Protein Binding ATP Binding Enzyme Activator Activity Protein Domain Specific Binding Sequence-specific DNA Binding
	Biological Process	Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Inner Cell Mass Cell Proliferation Chromatin Remodeling Transcription, DNA-templated Protein Phosphorylation Cellular Response To DNA Damage Stimulus Chromosome Segregation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Viral Process Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of DNA Binding Histone H4-K12 Acetylation Histone H3-K14 Acetylation Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Inflammatory Response Regulation Of Phosphorylation Of RNA Polymerase II C-terminal Domain Negative Regulation Of DNA Damage Checkpoint	Negative Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Cell Cycle Telomere Maintenance Via Recombination Telomere Maintenance DNA-dependent DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Nucleotide-excision Repair, DNA Gap Filling Transcription, DNA-templated Telomere Maintenance Via Telomerase Telomere Maintenance Via Semi-conservative Replication Positive Regulation Of Catalytic Activity Positive Regulation Of Transcription, DNA-templated
Pathways			Polymerase switching on the C-strand of the telomere Nucleotide Excision Repair Synthesis of DNA Chromosome Maintenance Lagging Strand Synthesis Gap-filling DNA repair synthesis and ligation in TC-NER Repair synthesis for gap-filling by DNA polymerase in TC-NER Extension of Telomeres S Phase Telomere C-strand (Lagging Strand) Synthesis Leading Strand Synthesis DNA strand elongation Repair synthesis of patch ~27-30 bases long by DNA polymerase Cell Cycle, Mitotic Gap-filling DNA repair synthesis and ligation in GG-NER Polymerase switching Global Genomic NER (GG-NER) Telomere Maintenance Transcription-coupled NER (TC-NER)
Drugs
Diseases
GWAS
Protein-Protein Interactions		18 interactors: C7orf25 C8orf33 CCNT1 CCNT2 CHFR CLDN1 HIST2H3C HIST2H4A HIST4H4 JMJD6 MESDC2 PRPF40A RFC1 RFC2 RFC3 RFC4 RFC5 TCERG1	19 interactors: BRCA1 BRD4 CASP3 CCND1 CDK4 CEBPA CSNK2B HDAC1 MYOC PCNA RELA RFC2 RFC3 RFC4 SMC1A SSBP3 TCEAL1 YWHAQ ZSCAN1
Entrez ID		23476	5981
HPRD ID		10574	00024
Ensembl ID		ENSG00000141867	ENSG00000035928
Uniprot IDs		O60885	P35251
PDB IDs		2I8N 2LSP 2NNU 2OSS 2OUO 2YEL 2YEM 3MXF 3P5O 3SVF 3SVG 3U5J 3U5K 3U5L 3UVW 3UVX 3UVY 3UW9 3ZYU 4A9L 4BJX 4BW1 4BW2 4BW3 4BW4 4C66 4C67 4DON 4E96 4F3I 4GPJ 4HBV 4HBW 4HBX 4HBY 4HXK 4HXL 4HXM 4HXN 4HXO 4HXP 4HXR 4HXS 4IOO 4IOQ 4IOR 4J0R 4J0S 4KV1 4KV4 4LR6 4LRG 4MEN 4MEO 4MEP 4MEQ	2EBU 2K6G 2K7F
Enriched GO Terms of Interacting Partners?		Telomere Maintenance Nucleotide-excision Repair, DNA Gap Filling Telomere Maintenance Via Semi-conservative Replication Nuclear DNA Replication Telomere Maintenance Via Recombination Mitotic Recombination DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening Transcription-coupled Nucleotide-excision Repair Cell Cycle Nucleotide-excision Repair DNA-dependent DNA Replication Mitotic Cell Cycle Homeostatic Process DNA Methylation On Cytosine Chromosome Organization DNA Metabolic Process Nucleobase-containing Compound Metabolic Process Chromatin Silencing At RDNA Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process DNA Recombination Cellular Nitrogen Compound Metabolic Process DNA Replication Nitrogen Compound Metabolic Process Chromatin Silencing Histone Demethylation Protein Demethylation Histone H4-K20 Demethylation Negative Regulation Of Megakaryocyte Differentiation Organelle Organization DNA Methylation Demethylation Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Hematopoietic Progenitor Cell Differentiation DNA Replication-dependent Nucleosome Assembly DNA Modification Cellular Metabolic Process DNA Repair Cell Cycle Process Gene Silencing Cellular Homeostasis Regulation Of Megakaryocyte Differentiation Gene Expression Cell Division CENP-A Containing Nucleosome Assembly Cellular Macromolecule Biosynthetic Process Cellular Response To DNA Damage Stimulus Macromolecule Biosynthetic Process	Mitotic Cell Cycle Nucleotide-excision Repair, DNA Gap Filling Cell Cycle Telomere Maintenance Via Semi-conservative Replication Nuclear DNA Replication Telomere Maintenance Via Recombination Cellular Response To DNA Damage Stimulus Mitotic Recombination DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening Chromosome Organization Transcription-coupled Nucleotide-excision Repair Nucleobase-containing Compound Metabolic Process Cell Cycle Process Negative Regulation Of Cell Cycle Cellular Response To Stress Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Response To Stress Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Telomere Maintenance Nitrogen Compound Metabolic Process Cellular Response To Stimulus Organelle Organization Regulation Of Cell Proliferation Positive Regulation Of Cellular Metabolic Process Nucleotide-excision Repair DNA Recombination Anatomical Structure Development Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle DNA-dependent DNA Replication DNA Replication Regulation Of Metabolic Process Developmental Process Regulation Of Cell Cycle Negative Regulation Of Biosynthetic Process DNA Repair Multicellular Organismal Development Response To Organic Substance Regulation Of G2/M Transition Of Mitotic Cell Cycle G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Biosynthetic Process DNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Response To Stimulus
Tagcloud ?		3d chip combining compensatory confirming consequently deprived downregulate driver enrichment estrogens everolimus feedback jq1 loops lted matrigel mediating mimic mtor myc ofmycby oncogenes otherwise resensitization signatures uncover upregulation xenograft	b12 bnip3 brac1 brca1 c1420t c1561t cnnd1 cpg cshmt dependency g80a gcpii homocysteine hyperhomocysteinemia hypermethylation hypomethioninemia hypothesize influencing inverse inversely island loci methionine methylation positively rarbeta1 rassf1 remethylation suppressors
Tagcloud (Difference) ?		3d chip combining compensatory confirming consequently deprived downregulate driver enrichment estrogens everolimus feedback jq1 loops lted matrigel mediating mimic mtor myc ofmycby oncogenes otherwise resensitization signatures uncover upregulation xenograft	b12 bnip3 brac1 brca1 c1420t c1561t cnnd1 cpg cshmt dependency g80a gcpii homocysteine hyperhomocysteinemia hypermethylation hypomethioninemia hypothesize influencing inverse inversely island loci methionine methylation positively rarbeta1 rassf1 remethylation suppressors
Tagcloud (Intersection) ?