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MED6 and PARP1
Number of citations of the paper that reports this interaction (PMID
15808511
)
75
Data Source:
HPRD
(in vitro, in vivo)
MED6
PARP1
Gene Name
mediator complex subunit 6
poly (ADP-ribose) polymerase 1
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Membrane
Mediator Complex
Nucleus
Nuclear Envelope
Nucleoplasm
Transcription Factor Complex
Nucleolus
Membrane
Molecular Function
RNA Polymerase II Transcription Cofactor Activity
Transcription Coactivator Activity
Protein Binding
Transcription Factor Binding
DNA Binding
NAD+ ADP-ribosyltransferase Activity
Protein Binding
Transcription Factor Binding
Zinc Ion Binding
Enzyme Binding
Identical Protein Binding
Poly(A) RNA Binding
Protein N-terminus Binding
NAD Binding
R-SMAD Binding
Biological Process
Regulation Of Transcription From RNA Polymerase II Promoter
Transcription Initiation From RNA Polymerase II Promoter
Gene Expression
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Telomere Maintenance
DNA Repair
Base-excision Repair
Double-strand Break Repair
Transcription, DNA-templated
Transcription From RNA Polymerase II Promoter
Transcription Initiation From RNA Polymerase II Promoter
Protein ADP-ribosylation
Transforming Growth Factor Beta Receptor Signaling Pathway
Gene Expression
Protein Autoprocessing
Signal Transduction Involved In Regulation Of Gene Expression
Macrophage Differentiation
Cellular Response To Insulin Stimulus
Regulation Of Growth Rate
DNA Damage Response, Detection Of DNA Damage
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of SMAD Protein Import Into Nucleus
Protein Poly-ADP-ribosylation
Cellular Response To Superoxide
Positive Regulation Of Transcription Regulatory Region DNA Binding
Pathways
PPARA activates gene expression
Fatty acid, triacylglycerol, and ketone body metabolism
Metabolism of lipids and lipoproteins
Generic Transcription Pathway
Transcriptional regulation of white adipocyte differentiation
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Loss of Function of TGFBR2 in Cancer
TGFBR2 MSI Frameshift Mutants in Cancer
SMAD2/3 Phosphorylation Motif Mutants in Cancer
Loss of Function of SMAD2/3 in Cancer
TGFBR2 Kinase Domain Mutants in Cancer
Loss of Function of SMAD4 in Cancer
SMAD2/3 MH2 Domain Mutants in Cancer
TGFBR1 KD Mutants in Cancer
Downregulation of SMAD2/3:SMAD4 transcriptional activity
TGFBR1 LBD Mutants in Cancer
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
Loss of Function of TGFBR1 in Cancer
Generic Transcription Pathway
Signaling by TGF-beta Receptor Complex
Signaling by TGF-beta Receptor Complex in Cancer
SMAD4 MH2 Domain Mutants in Cancer
Drugs
Carba-Nicotinamide-Adenine-Dinucleotide
NU1025
Nicotinamide
2-{3-[4-(4-Fluorophenyl)-3,6-Dihydro-1(2h)-Pyridinyl]Propyl}-8-Methyl-4(3h)-Quinazolinone
3-Methoxybenzamide
2-(4-Chlorophenyl)-5-Quinoxalinecarboxamide
3,4-Dihydro-5-Methyl-Isoquinolinone
2-(3\'-Methoxyphenyl) Benzimidazole-4-Carboxamide
6-AMINO-BENZO[DE]ISOQUINOLINE-1,3-DIONE
(2R)-2-(7-carbamoyl-1H-benzimidazol-2-yl)-2-methylpyrrolidinium
trans-4-(7-carbamoyl-1H-benzimidazol-2-yl)-1-propylpiperidinium
5-FLUORO-1-[4-(4-PHENYL-3,6-DIHYDROPYRIDIN-1(2H)-YL)BUTYL]QUINAZOLINE-2,4(1H,3H)-DIONE
Diseases
GWAS
Melanoma (
21983785
)
Protein-Protein Interactions
15 interactors:
BCL6
CTDP1
ESR1
ESR2
MED25
MED8
MED9
PARP1
RARA
SMAD1
SMAD2
SMARCA4
SREBF1
SUZ12
TARDBP
84 interactors:
APLF
APTX
ATM
BCL2
BUB3
CASP1
CASP3
CASP7
CASP8
CD86
CDKN1A
CENPA
CENPB
CREBBP
CTSB
CTSG
E2F1
ERCC6
ERG
FOXO1
GTF2F1
GZMB
GZMM
H2AFY
HDAC1
HDAC3
HIST1H1A
HIST1H1C
HIST1H2BA
HIST1H4A
HIST1H4C
HIST2H2AA3
HMGA1
HOXB7
HSPA2
KAT2B
LIG3
LZTR1
MED14
MED6
MYBL2
NCL
NCOA6
NEDD8
NFATC1
NFKB1
NPM1
NRF1
PARP2
PARP3
PCNA
PIAS4
POLA1
POLA2
POLB
POU2F1
PRKDC
RARA
RBM14
RELA
RNF146
RPS3A
RXRA
SENP1
SENP3
SIRT1
SP1
SREK1
SUMO1
SUMO2
SUPT16H
SWAP70
TCF4
TP53
TRIM29
UBE2I
UHRF1
WRN
XRCC1
XRCC5
XRCC6
ZBTB16
ZBTB9
ZNF423
Entrez ID
10001
142
HPRD ID
04284
01435
Ensembl ID
ENSG00000133997
ENSG00000143799
Uniprot IDs
O75586
P09874
PDB IDs
1UK0
1UK1
1WOK
2COK
2CR9
2CS2
2DMJ
2JVN
2L30
2L31
2RCW
2RD6
2RIQ
3GJW
3GN7
3L3L
3L3M
3OD8
3ODA
3ODC
3ODE
4AV1
4DQY
4GV7
4HHY
4HHZ
4L6S
Enriched GO Terms of Interacting Partners
?
Transcription From RNA Polymerase II Promoter
Transcription, DNA-templated
RNA Biosynthetic Process
Regulation Of Transcription From RNA Polymerase II Promoter
RNA Metabolic Process
Gene Expression
Negative Regulation Of Gene Expression
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Transcription Initiation From RNA Polymerase II Promoter
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Nucleobase-containing Compound Metabolic Process
DNA-templated Transcription, Initiation
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Biosynthetic Process
Regulation Of Gene Expression
Regulation Of Nitrogen Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Nitrogen Compound Metabolic Process
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of Biosynthetic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Gene Expression
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Cellular Biosynthetic Process
Negative Regulation Of Nucleic Acid-templated Transcription
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Cellular Metabolic Process
Regulation Of Metabolic Process
Negative Regulation Of Cellular Metabolic Process
Intracellular Estrogen Receptor Signaling Pathway
Organ Growth
Regulation Of Binding
Positive Regulation Of Metabolic Process
Positive Regulation Of Binding
Regulation Of Cell Proliferation
Tissue Morphogenesis
Negative Regulation Of Cell Proliferation
Urogenital System Development
Cellular Response To Organic Cyclic Compound
Cellular Metabolic Process
Primary MiRNA Processing
Epithelial Cell Development
Regulation Of Gene Expression, Epigenetic
Positive Regulation Of Cellular Metabolic Process
Nucleobase-containing Compound Metabolic Process
Cellular Aromatic Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Positive Regulation Of Metabolic Process
Cellular Response To DNA Damage Stimulus
Positive Regulation Of Transcription, DNA-templated
DNA Metabolic Process
Regulation Of Metabolic Process
Regulation Of Nitrogen Compound Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Gene Expression
Chromosome Organization
Nitrogen Compound Metabolic Process
Positive Regulation Of Cellular Biosynthetic Process
DNA Repair
Cellular Response To Stress
Regulation Of Gene Expression
Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Response To Stress
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Cellular Metabolic Process
RNA Biosynthetic Process
Transcription From RNA Polymerase II Promoter
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
RNA Metabolic Process
Transcription, DNA-templated
Telomere Maintenance
Negative Regulation Of Transcription, DNA-templated
Viral Process
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Cellular Metabolic Process
Negative Regulation Of Gene Expression
Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Biosynthetic Process
Gene Expression
Apoptotic Signaling Pathway
Base-excision Repair
Regulation Of Apoptotic Process
Biosynthetic Process
Cellular Response To Stimulus
Organelle Organization
Response To Stimulus
Tagcloud
?
ageing
ascribes
atm
attrition
brca1
complexity
ctip
ends
fusions
homologous
instability
insufficient
joining
ku70
lig3
lig4
mechanistically
nhej
overhang
rampant
relies
repeats
telomere
telomeres
telomeric
trf2
unanticipated
uncapped
underlining
Tagcloud (Difference)
?
ageing
ascribes
atm
attrition
brca1
complexity
ctip
ends
fusions
homologous
instability
insufficient
joining
ku70
lig3
lig4
mechanistically
nhej
overhang
rampant
relies
repeats
telomere
telomeres
telomeric
trf2
unanticipated
uncapped
underlining
Tagcloud (Intersection)
?