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MED6 and SREBF1
Number of citations of the paper that reports this interaction (PMID
10235267
)
104
Data Source:
BioGRID
(biochemical, affinity chromatography technology, pull down)
MED6
SREBF1
Gene Name
mediator complex subunit 6
sterol regulatory element binding transcription factor 1
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Membrane
Mediator Complex
Golgi Membrane
Nucleus
Nuclear Envelope
Nucleoplasm
Cytoplasm
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Cytosol
ER To Golgi Transport Vesicle Membrane
Integral Component Of Membrane
Protein Complex
Molecular Function
RNA Polymerase II Transcription Cofactor Activity
Transcription Coactivator Activity
Protein Binding
Transcription Factor Binding
DNA Binding
Chromatin Binding
Sequence-specific DNA Binding Transcription Factor Activity
Protein Binding
Protein Kinase Binding
Protein Complex Binding
Sterol Response Element Binding
Sequence-specific DNA Binding
Protein Dimerization Activity
Biological Process
Regulation Of Transcription From RNA Polymerase II Promoter
Transcription Initiation From RNA Polymerase II Promoter
Gene Expression
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Heart Rate By Chemical Signal
Transcription, DNA-templated
Regulation Of Transcription From RNA Polymerase II Promoter
Lipid Metabolic Process
Aging
Circadian Rhythm
Cholesterol Metabolic Process
Insulin Receptor Signaling Pathway
Lipid Biosynthetic Process
Cellular Response To Starvation
Response To Glucose
Positive Regulation Of Triglyceride Biosynthetic Process
Regulation Of Fatty Acid Metabolic Process
Lung Development
Positive Regulation Of Histone Deacetylation
Response To Food
Response To Retinoic Acid
Response To Progesterone
Response To Glucagon
Response To Drug
Cellular Lipid Metabolic Process
Small Molecule Metabolic Process
Positive Regulation Of Cholesterol Biosynthetic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Insulin Secretion
Response To CAMP
Cellular Response To Fatty Acid
Pathways
PPARA activates gene expression
Fatty acid, triacylglycerol, and ketone body metabolism
Metabolism of lipids and lipoproteins
Generic Transcription Pathway
Transcriptional regulation of white adipocyte differentiation
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
RORA activates circadian gene expression
Drugs
Diseases
GWAS
Parkinson's disease (
21738487
)
Protein-Protein Interactions
15 interactors:
BCL6
CTDP1
ESR1
ESR2
MED25
MED8
MED9
PARP1
RARA
SMAD1
SMAD2
SMARCA4
SREBF1
SUZ12
TARDBP
35 interactors:
AR
ATXN1
ATXN1L
CDK8
CREBBP
ESR1
ESR2
GSK3B
HNF4A
ID3
KLF13
LMNA
MAPK1
MAPK3
MED1
MED12
MED13
MED14
MED17
MED23
MED24
MED25
MED26
MED6
MED7
NR0B1
SIRT1
SMARCD3
SP1
SREBF2
SUMO1
TWIST2
UBE2I
YY1
ZBTB7C
Entrez ID
10001
6720
HPRD ID
04284
01701
Ensembl ID
ENSG00000133997
ENSG00000072310
Uniprot IDs
O75586
B4DEU6
P36956
PDB IDs
1AM9
Enriched GO Terms of Interacting Partners
?
Transcription From RNA Polymerase II Promoter
Transcription, DNA-templated
RNA Biosynthetic Process
Regulation Of Transcription From RNA Polymerase II Promoter
RNA Metabolic Process
Gene Expression
Negative Regulation Of Gene Expression
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Transcription Initiation From RNA Polymerase II Promoter
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Nucleobase-containing Compound Metabolic Process
DNA-templated Transcription, Initiation
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Biosynthetic Process
Regulation Of Gene Expression
Regulation Of Nitrogen Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Nitrogen Compound Metabolic Process
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of Biosynthetic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Gene Expression
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Cellular Biosynthetic Process
Negative Regulation Of Nucleic Acid-templated Transcription
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Cellular Metabolic Process
Regulation Of Metabolic Process
Negative Regulation Of Cellular Metabolic Process
Intracellular Estrogen Receptor Signaling Pathway
Organ Growth
Regulation Of Binding
Positive Regulation Of Metabolic Process
Positive Regulation Of Binding
Regulation Of Cell Proliferation
Tissue Morphogenesis
Negative Regulation Of Cell Proliferation
Urogenital System Development
Cellular Response To Organic Cyclic Compound
Cellular Metabolic Process
Primary MiRNA Processing
Epithelial Cell Development
Regulation Of Gene Expression, Epigenetic
Regulation Of Transcription From RNA Polymerase II Promoter
Transcription Initiation From RNA Polymerase II Promoter
DNA-templated Transcription, Initiation
Transcription, DNA-templated
RNA Biosynthetic Process
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Transcription From RNA Polymerase II Promoter
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Regulation Of Gene Expression
Regulation Of Nitrogen Compound Metabolic Process
RNA Metabolic Process
Positive Regulation Of Gene Expression
Gene Expression
Positive Regulation Of Transcription, DNA-templated
Nucleobase-containing Compound Metabolic Process
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Cellular Nitrogen Compound Metabolic Process
Positive Regulation Of Cellular Biosynthetic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Nitrogen Compound Metabolic Process
Regulation Of Metabolic Process
Biosynthetic Process
Positive Regulation Of Cellular Metabolic Process
Intracellular Steroid Hormone Receptor Signaling Pathway
Positive Regulation Of Metabolic Process
Intracellular Receptor Signaling Pathway
Androgen Receptor Signaling Pathway
Cellular Metabolic Process
Negative Regulation Of Cell Differentiation
Negative Regulation Of Biosynthetic Process
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Anatomical Structure Development
Regulation Of Cellular Process
Negative Regulation Of Gene Expression
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Developmental Process
Regulation Of Cellular Response To Heat
Regulation Of Cell Differentiation
Organ Development
Cell Differentiation
Metabolic Process
Tagcloud
?
aberrations
acly
biphasic
cascade
chemoprevention
citrate
desaturase
disturbed
fads2
fatty
harboring
hbv
hcc
hepatocytes
lipid
livers
lyase
metabolism
mtor
pre
remarkably
s2
starting
sterol
subsided
synchronized
transgenic
tumorigenesis
upregulate
Tagcloud (Difference)
?
aberrations
acly
biphasic
cascade
chemoprevention
citrate
desaturase
disturbed
fads2
fatty
harboring
hbv
hcc
hepatocytes
lipid
livers
lyase
metabolism
mtor
pre
remarkably
s2
starting
sterol
subsided
synchronized
transgenic
tumorigenesis
upregulate
Tagcloud (Intersection)
?