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MED6 and SMARCA4
Number of citations of the paper that reports this interaction (PMID
22668559
)
1
Data Source:
BioGRID
(pull down)
MED6
SMARCA4
Gene Name
mediator complex subunit 6
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Membrane
Mediator Complex
Nuclear Chromatin
Heterochromatin
Extracellular Space
Nucleus
Nucleoplasm
Nuclear Euchromatin
Perichromatin Fibrils
Nucleolus
Membrane
SWI/SNF Complex
Protein Complex
NpBAF Complex
NBAF Complex
Molecular Function
RNA Polymerase II Transcription Cofactor Activity
Transcription Coactivator Activity
Protein Binding
Transcription Factor Binding
RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding
RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding
RNA Polymerase II Transcription Coactivator Activity
P53 Binding
Transcription Coactivator Activity
Transcription Corepressor Activity
Helicase Activity
Protein Binding
ATP Binding
DNA-dependent ATPase Activity
Tat Protein Binding
Nucleosomal DNA Binding
Protein N-terminus Binding
Androgen Receptor Binding
DNA Polymerase Binding
Lysine-acetylated Histone Binding
Biological Process
Regulation Of Transcription From RNA Polymerase II Promoter
Transcription Initiation From RNA Polymerase II Promoter
Gene Expression
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Cell Morphogenesis
Vasculogenesis
Blastocyst Growth
Blastocyst Hatching
Liver Development
Neural Retina Development
Chromatin Organization
Nucleosome Disassembly
Chromatin Remodeling
Methylation-dependent Chromatin Silencing
Transcription, DNA-templated
Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Transcription From RNA Polymerase II Promoter During Mitosis
Glial Cell Fate Determination
DNA Methylation On Cytosine Within A CG Sequence
Stem Cell Maintenance
Positive Regulation Of Wnt Signaling Pathway
Extracellular Matrix Organization
Keratinocyte Differentiation
Negative Regulation Of Cell Growth
Forebrain Development
Hindbrain Development
Embryonic Hindlimb Morphogenesis
Aortic Smooth Muscle Cell Differentiation
ATP-dependent Chromatin Remodeling
Positive Regulation Of DNA Binding
Positive Regulation By Host Of Viral Transcription
Histone H3 Acetylation
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Embryonic Organ Morphogenesis
Epidermis Morphogenesis
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Definitive Erythrocyte Differentiation
Heart Trabecula Formation
Negative Regulation Of Androgen Receptor Signaling Pathway
Lens Fiber Cell Development
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways
PPARA activates gene expression
Fatty acid, triacylglycerol, and ketone body metabolism
Metabolism of lipids and lipoproteins
Generic Transcription Pathway
Transcriptional regulation of white adipocyte differentiation
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Chromatin modifying enzymes
Chromatin organization
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
TCF dependent signaling in response to WNT
RNF mutants show enhanced WNT signaling and proliferation
formation of the beta-catenin:TCF transactivating complex
XAV939 inhibits tankyrase, stabilizing AXIN
Signaling by Wnt
Signaling by WNT in cancer
RMTs methylate histone arginines
Drugs
Diseases
GWAS
Coronary heart disease (
21347282
)
Protein-Protein Interactions
15 interactors:
BCL6
CTDP1
ESR1
ESR2
MED25
MED8
MED9
PARP1
RARA
SMAD1
SMAD2
SMARCA4
SREBF1
SUZ12
TARDBP
73 interactors:
ACTB
ACTL6A
AHR
AR
ARID1A
ARID1B
ARID2
BRCA1
BRWD1
CARM1
CBX5
CCNE1
CDK19
CDK8
CDKN2A
CDX2
CEBPA
CEBPB
CHD4
CHMP5
CIITA
CREB1
CTNNB1
DPF3
ESR1
ETS2
FANCA
GATA1
GMNN
H2AFX
H3F3A
HIST1H3A
HIST1H4F
HIST2H2BE
HIST2H3C
HSF1
HSF4
IKZF1
KLF1
MBD3
MDM2
MED17
MED6
MKL1
MPHOSPH6
MPP6
MYC
MYOCD
NR3C1
NR4A2
PABPN1
PAX6
PBRM1
PHB
RAP1A
RB1
RBL1
RBL2
RELB
RFXAP
SIN3A
SIN3B
SMARCB1
SMARCC1
SMARCE1
SS18
SS18L1
STAT2
STAT3
STK11
TMF1
TP53
ZMYND11
Entrez ID
10001
6597
HPRD ID
04284
04459
Ensembl ID
ENSG00000133997
ENSG00000127616
Uniprot IDs
O75586
A7E2E1
B3KNW7
P51532
Q9HBD4
PDB IDs
2GRC
2H60
3UVD
Enriched GO Terms of Interacting Partners
?
Transcription From RNA Polymerase II Promoter
Transcription, DNA-templated
RNA Biosynthetic Process
Regulation Of Transcription From RNA Polymerase II Promoter
RNA Metabolic Process
Gene Expression
Negative Regulation Of Gene Expression
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Transcription Initiation From RNA Polymerase II Promoter
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Nucleobase-containing Compound Metabolic Process
DNA-templated Transcription, Initiation
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Biosynthetic Process
Regulation Of Gene Expression
Regulation Of Nitrogen Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Nitrogen Compound Metabolic Process
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of Biosynthetic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Gene Expression
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Cellular Biosynthetic Process
Negative Regulation Of Nucleic Acid-templated Transcription
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Cellular Metabolic Process
Regulation Of Metabolic Process
Negative Regulation Of Cellular Metabolic Process
Intracellular Estrogen Receptor Signaling Pathway
Organ Growth
Regulation Of Binding
Positive Regulation Of Metabolic Process
Positive Regulation Of Binding
Regulation Of Cell Proliferation
Tissue Morphogenesis
Negative Regulation Of Cell Proliferation
Urogenital System Development
Cellular Response To Organic Cyclic Compound
Cellular Metabolic Process
Primary MiRNA Processing
Epithelial Cell Development
Regulation Of Gene Expression, Epigenetic
Transcription, DNA-templated
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of RNA Metabolic Process
RNA Biosynthetic Process
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Chromatin Organization
Nucleobase-containing Compound Metabolic Process
Regulation Of Gene Expression
Positive Regulation Of Transcription, DNA-templated
Gene Expression
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
RNA Metabolic Process
Positive Regulation Of Gene Expression
Cellular Nitrogen Compound Metabolic Process
Positive Regulation Of Cellular Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Chromosome Organization
Cellular Macromolecule Biosynthetic Process
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Gene Expression
Nitrogen Compound Metabolic Process
Macromolecule Biosynthetic Process
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Chromatin Modification
Negative Regulation Of Biosynthetic Process
Regulation Of Metabolic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Cellular Metabolic Process
Organelle Organization
Biosynthetic Process
Transcription From RNA Polymerase II Promoter
Positive Regulation Of Metabolic Process
Negative Regulation Of Cellular Metabolic Process
Chromatin Remodeling
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Cellular Metabolic Process
Regulation Of Cellular Process
Intracellular Steroid Hormone Receptor Signaling Pathway
Intracellular Receptor Signaling Pathway
Anatomical Structure Development
Developmental Process
Chromatin Assembly Or Disassembly
System Development
Multicellular Organismal Development
ATP-dependent Chromatin Remodeling
Tagcloud
?
abnormality
arid1a
coinactivation
copyright
fish
frame
harboring
heterozygous
infancy
insights
malignancies
missense
monoploid
mrts
pbrm1
protected
remodeling
reserved
rhabdoid
rights
screened
sense
snf
subunits
swi
trisomy
truncating
Tagcloud (Difference)
?
abnormality
arid1a
coinactivation
copyright
fish
frame
harboring
heterozygous
infancy
insights
malignancies
missense
monoploid
mrts
pbrm1
protected
remodeling
reserved
rhabdoid
rights
screened
sense
snf
subunits
swi
trisomy
truncating
Tagcloud (Intersection)
?