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MED6 and SMAD1
Number of citations of the paper that reports this interaction (PMID
12167862
)
46
Data Source:
HPRD
(in vivo)
MED6
SMAD1
Gene Name
mediator complex subunit 6
SMAD family member 1
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Membrane
Mediator Complex
Intracellular
Nucleus
Nuclear Inner Membrane
Nucleoplasm
Transcription Factor Complex
Cytoplasm
Cytosol
Integral Component Of Membrane
Protein Complex
Molecular Function
RNA Polymerase II Transcription Cofactor Activity
Transcription Coactivator Activity
Protein Binding
Transcription Factor Binding
RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding
RNA Polymerase II Core Promoter Sequence-specific DNA Binding
RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription
Sequence-specific DNA Binding Transcription Factor Activity
Receptor Signaling Protein Activity
Protein Binding
Protein Kinase Binding
Transforming Growth Factor Beta Receptor, Pathway-specific Cytoplasmic Mediator Activity
Identical Protein Binding
Metal Ion Binding
Co-SMAD Binding
I-SMAD Binding
Biological Process
Regulation Of Transcription From RNA Polymerase II Promoter
Transcription Initiation From RNA Polymerase II Promoter
Gene Expression
Positive Regulation Of Transcription From RNA Polymerase II Promoter
MAPK Cascade
Ureteric Bud Development
Mesodermal Cell Fate Commitment
Osteoblast Fate Commitment
Transcription, DNA-templated
Protein Phosphorylation
Inflammatory Response
Signal Transduction
Transforming Growth Factor Beta Receptor Signaling Pathway
SMAD Protein Complex Assembly
Gamete Generation
Negative Regulation Of Cell Proliferation
Embryonic Pattern Specification
Response To Organonitrogen Compound
Positive Regulation Of Gene Expression
Negative Regulation Of Muscle Cell Apoptotic Process
BMP Signaling Pathway
Midbrain Development
Hindbrain Development
Primary MiRNA Processing
Wound Healing
Response To Drug
Homeostatic Process
Positive Regulation Of Osteoblast Differentiation
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Dendrite Morphogenesis
Cartilage Development
Cardiac Muscle Cell Proliferation
Bone Development
Positive Regulation Of Cartilage Development
Cellular Response To BMP Stimulus
Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus
Pathways
PPARA activates gene expression
Fatty acid, triacylglycerol, and ketone body metabolism
Metabolism of lipids and lipoproteins
Generic Transcription Pathway
Transcriptional regulation of white adipocyte differentiation
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Signaling by BMP
Drugs
Diseases
GWAS
Protein-Protein Interactions
15 interactors:
BCL6
CTDP1
ESR1
ESR2
MED25
MED8
MED9
PARP1
RARA
SMAD1
SMAD2
SMARCA4
SREBF1
SUZ12
TARDBP
138 interactors:
ACVR1
ACVRL1
AKR1B1
ANKRD27
AP2A2
APP
AR
ARHGEF6
ARL4D
BMPR1A
BTBD2
BTG2
CAMSAP1
CDK7
CDK9
CHMP3
COL4A1
DVL1
ECSIT
EIF2AK4
ELP3
EP300
ERBB2IP
EWSR1
FBXL12
FBXO30
FHL5
FOXG1
FRZB
GDF6
GLI3
GMEB1
GSC
GSK3B
HBP1
HIPK2
HOXA13
HOXA5
HOXC8
HOXD13
ICK
ING2
INPP4A
IRF2BP1
KAT2B
KMT2D
LEF1
LEMD3
MAPK1
MAST4
MBD1
MECOM
MED6
MEN1
MGA
MKL2
NAT9
NEDD4
NEDD9
NEUROG1
NKX3-2
NOTCH2
OAZ1
OAZ3
PAK1
PARD3B
PIAS1
PIAS4
PIGQ
PLEKHB1
PREB
PSMB4
PSMD1
PSMD11
PUM1
RAB2B
RAB30
RAB34
RAB38
RAB3B
RAB6B
RAC2
RAN
RAP2A
RASD2
RASL12
RFX1
RHEBL1
RHOG
RPS27A
SF3B1
SKI
SKIL
SMAD2
SMAD3
SMAD4
SMAD5
SMAD6
SMARCE1
SMURF1
SMURF2
SNIP1
SNRNP70
SOX5
SQSTM1
SS18L1
STARD13
STUB1
SUV39H1
TCF20
TGFBR1
TNNT1
TOB1
TRIP6
TTF1
TTF2
UBA52
UBC
UBE2Z
UBXN1
USP45
VEPH1
WDR77
XPC
XPO1
YAP1
YY1
ZBTB44
ZDHHC3
ZEB2
ZNF251
ZNF423
ZNF510
ZNF512B
ZNF521
ZNF76
ZNF8
ZSCAN4
Entrez ID
10001
4086
HPRD ID
04284
03356
Ensembl ID
ENSG00000133997
ENSG00000170365
Uniprot IDs
O75586
Q15797
PDB IDs
1KHU
2LAW
2LAX
2LAY
2LAZ
2LB0
2LB1
Enriched GO Terms of Interacting Partners
?
Transcription From RNA Polymerase II Promoter
Transcription, DNA-templated
RNA Biosynthetic Process
Regulation Of Transcription From RNA Polymerase II Promoter
RNA Metabolic Process
Gene Expression
Negative Regulation Of Gene Expression
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Transcription Initiation From RNA Polymerase II Promoter
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Nucleobase-containing Compound Metabolic Process
DNA-templated Transcription, Initiation
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Biosynthetic Process
Regulation Of Gene Expression
Regulation Of Nitrogen Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Nitrogen Compound Metabolic Process
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of Biosynthetic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Gene Expression
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Cellular Biosynthetic Process
Negative Regulation Of Nucleic Acid-templated Transcription
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Cellular Metabolic Process
Regulation Of Metabolic Process
Negative Regulation Of Cellular Metabolic Process
Intracellular Estrogen Receptor Signaling Pathway
Organ Growth
Regulation Of Binding
Positive Regulation Of Metabolic Process
Positive Regulation Of Binding
Regulation Of Cell Proliferation
Tissue Morphogenesis
Negative Regulation Of Cell Proliferation
Urogenital System Development
Cellular Response To Organic Cyclic Compound
Cellular Metabolic Process
Primary MiRNA Processing
Epithelial Cell Development
Regulation Of Gene Expression, Epigenetic
Regulation Of Nitrogen Compound Metabolic Process
Transcription, DNA-templated
Regulation Of RNA Metabolic Process
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Transcription, DNA-templated
Regulation Of Transcription From RNA Polymerase II Promoter
RNA Biosynthetic Process
Gene Expression
Regulation Of Gene Expression
RNA Metabolic Process
Regulation Of Metabolic Process
Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Gene Expression
Transforming Growth Factor Beta Receptor Signaling Pathway
Regulation Of Cellular Process
Positive Regulation Of Macromolecule Biosynthetic Process
Cellular Response To Transforming Growth Factor Beta Stimulus
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Response To Transforming Growth Factor Beta
Cellular Nitrogen Compound Metabolic Process
Cellular Macromolecule Biosynthetic Process
Positive Regulation Of Cellular Biosynthetic Process
Macromolecule Biosynthetic Process
Positive Regulation Of Cellular Metabolic Process
Positive Regulation Of Metabolic Process
Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Negative Regulation Of Biosynthetic Process
Nitrogen Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Negative Regulation Of Cellular Metabolic Process
Regulation Of Cellular Response To Growth Factor Stimulus
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Regulation Of Signal Transduction
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Gene Expression
Negative Regulation Of Nucleic Acid-templated Transcription
Biosynthetic Process
Negative Regulation Of RNA Biosynthetic Process
Enzyme Linked Receptor Protein Signaling Pathway
Negative Regulation Of Cellular Response To Growth Factor Stimulus
Signal Transduction
Regulation Of Signaling
Cellular Response To Growth Factor Stimulus
Pattern Specification Process
Signaling
Transcription From RNA Polymerase II Promoter
Tagcloud
?
balance
cav1
collagens
cytokeratin
dialytic
discontinuation
emt
eventually
fibrosis
fluids
fn
fsp
hyperactivation
invading
junction
laminin
matrices
mcs
mek
mesothelial
pd
peritoneal
peritoneum
proteomics
smad2
snail
stroma
thickness
zo
Tagcloud (Difference)
?
balance
cav1
collagens
cytokeratin
dialytic
discontinuation
emt
eventually
fibrosis
fluids
fn
fsp
hyperactivation
invading
junction
laminin
matrices
mcs
mek
mesothelial
pd
peritoneal
peritoneum
proteomics
smad2
snail
stroma
thickness
zo
Tagcloud (Intersection)
?