RYBP and FADD

Number of citations of the paper that reports this interaction (PMID 11395500)
16

Data Source:
HPRD (in vivo)

		RYBP	FADD
Gene Name		RING1 and YY1 binding protein	Fas (TNFRSF6)-associated via death domain
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm PcG Protein Complex	Cytosol Death-inducing Signaling Complex CD95 Death-inducing Signaling Complex Neuron Projection Cell Body Membrane Raft Ripoptosome
	Molecular Function	DNA Binding Transcription Corepressor Activity Protein Binding Zinc Ion Binding	Protease Binding Death Receptor Binding Tumor Necrosis Factor Receptor Binding Protein Binding Protein Complex Binding Tumor Necrosis Factor Receptor Superfamily Binding Death Effector Domain Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Apoptotic Process Multicellular Organismal Development Histone H2A Monoubiquitination	Positive Regulation Of T Cell Mediated Cytotoxicity Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Positive Regulation Of Adaptive Immune Response Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Viral Process Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production T Cell Differentiation In Thymus Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway TRAIL-activated Apoptotic Signaling Pathway Positive Regulation Of Activated T Cell Proliferation T Cell Homeostasis Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Positive Regulation Of Macrophage Differentiation Positive Regulation Of Proteolysis Positive Regulation Of Transcription From RNA Polymerase II Promoter Lymph Node Development Spleen Development Thymus Development Protein Heterooligomerization Defense Response To Virus Positive Regulation Of Type I Interferon-mediated Signaling Pathway Negative Regulation Of Necroptotic Process Negative Regulation Of Activation-induced Cell Death Of T Cells Cellular Response To Mechanical Stimulus Motor Neuron Apoptotic Process Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Activation Of Cysteine-type Endopeptidase Activity Necroptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of CD8-positive, Alpha-beta Cytotoxic T Cell Extravasation Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways			Regulation by c-FLIP Caspase-8 activation by cleavage Death Receptor Signalling Dimerization of procaspase-8 TRAIL signaling TRIF-mediated TLR3/TLR4 signaling FasL/ CD95L signaling MyD88-independent cascade Activated TLR4 signalling RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll-Like Receptors Cascades Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade Programmed Cell Death NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 TRIF-mediated programmed cell death Extrinsic Pathway Innate Immune System
Drugs
Diseases
GWAS		Height ( 20881960 23563607)
Protein-Protein Interactions		17 interactors: ABL1 CASP10 CASP8 CBX2 E2F2 E2F3 E2F4 E2F6 FADD GABPB1 GABPB2 MDM2 RING1 RNF2 SOCS2 YY1 ZFP42	45 interactors: ABCA1 ANK3 ATG5 CASP10 CASP8 CASP8AP2 CFLAR CSNK1A1 DAP3 DAPK1 DDX24 DEDD EDA2R FAF1 FAS FASLG HIPK3 IKBKG IRAK1 LRRCC1 MBD4 MKRN1 MOB4 MYD88 NACA NOL3 PARK7 PEA15 PIDD1 PRKCZ PTPN13 RALBP1 RAP1A RIPK1 RYBP SPOP STAT1 SUMO1 TAB1 TNFRSF10A TNFRSF10B TRADD TRAF2 TRIM21 XPO5
Entrez ID		23429	8772
HPRD ID		09607	03909
Ensembl ID			ENSG00000168040
Uniprot IDs		Q8N488	Q13158
PDB IDs		3IXS	1A1W 1A1Z 1E3Y 1E41 2GF5 3EZQ 3OQ9
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Mitotic Cell Cycle Regulation Of Transcription From RNA Polymerase II Promoter TRAIL-activated Apoptotic Signaling Pathway RNA Metabolic Process Cell Cycle Gene Expression Apoptotic Signaling Pathway Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Cellular Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To UV-C Histone H2A Monoubiquitination Positive Regulation Of Macrophage Differentiation Negative Regulation Of Necroptotic Process Apoptotic Process Negative Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process Programmed Cell Death Negative Regulation Of Necrotic Cell Death Histone H2A Ubiquitination Positive Regulation Of Gene Expression Regulation Of Necroptotic Process Cell Death Death Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Histone Monoubiquitination Metabolic Process Organelle Organization Regulation Of Necrotic Cell Death Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Cellular Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter	Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Apoptotic Process Regulation Of Cell Death Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Signal Transduction Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Signal Transduction Positive Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Signaling Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Endopeptidase Activity Activation Of Cysteine-type Endopeptidase Activity Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Peptidase Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Zymogen Activation Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Protein Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Apoptotic Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Extrinsic Apoptotic Signaling Pathway Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Proteolysis Regulation Of Endopeptidase Activity Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Protein Metabolic Process Regulation Of Peptidase Activity Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Negative Regulation Of Programmed Cell Death Protein Processing Regulation Of Proteolysis Negative Regulation Of Cell Death Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Positive Regulation Of Metabolic Process Regulation Of Catalytic Activity Activation Of Protein Kinase Activity
Tagcloud ?		3p amplifications breeding classic consuming cooperates costly daunting drive drivers driving endogenously engineering faithful foxp1 hidden incurable pc pten ptenloxp rapidcap recreate reside sensitized shq1 trp53 trp53loxp unmet validation	adaptor appear characterization convey daxx death domains effector far growing homologies insights isolation jun mammalian members mort necrosis represents rip seem share signals superfamily tnfr tradd traf traf1 transmit
Tagcloud (Difference) ?		3p amplifications breeding classic consuming cooperates costly daunting drive drivers driving endogenously engineering faithful foxp1 hidden incurable pc pten ptenloxp rapidcap recreate reside sensitized shq1 trp53 trp53loxp unmet validation	adaptor appear characterization convey daxx death domains effector far growing homologies insights isolation jun mammalian members mort necrosis represents rip seem share signals superfamily tnfr tradd traf traf1 transmit
Tagcloud (Intersection) ?