RYBP and KIF20A

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		RYBP	KIF20A
Description		RING1 and YY1 binding protein	kinesin family member 20A
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm PcG Protein Complex	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Spindle Cytoskeleton Kinesin Complex Microtubule Midbody Cleavage Furrow Intercellular Bridge Mitotic Spindle
	Molecular Function	Nucleic Acid Binding DNA Binding Transcription Coregulator Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Metal Ion Binding	Nucleotide Binding Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding ATP Hydrolysis Activity Protein Kinase Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Remodeling Regulation Of DNA-templated Transcription Apoptotic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of DNA-templated Transcription	Mitotic Cytokinesis Microtubule Bundle Formation Microtubule-based Movement Protein Transport Regulation Of Cytokinesis Midbody Abscission
Pathways		RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Transcriptional Regulation by E2F6	MHC class II antigen presentation COPI-dependent Golgi-to-ER retrograde traffic Mitotic Telophase/Cytokinesis Kinesins
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 32296059) Body size at age 10 ( 32376654) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Height ( 23563607 31562340 28552196 25429064 25282103 20881960) Hip circumference adjusted for BMI ( 34021172) Medication use (beta blocking agents) ( 31015401) Metabolite levels ( 23823483) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309) Resting-state electroencephalogram vigilance ( 29703947) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28448500 25673412 34021172)	Autism spectrum disorder or schizophrenia ( 28540026)
Interacting Genes		38 interacting genes: ABL1 BANP CASP10 CASP8 CBX2 CRK E2F2 E2F3 E2F4 E2F6 EAF1 FADD FANK1 FHL3 GABPB1 GABPB2 HSPB1 KIF20A KPNA4 MAPK8IP2 MDM2 NMI NOS1AP PADI4 PRPF6 PSMB1 PTEN RBBP4 RING1 RNF2 RNF8 SOCS2 UBC UBE3A XAGE1A XAGE1B YY1 ZFP42	10 interacting genes: ATOSB CDC14A LRRK1 RAB6A RAB6B RBFOX2 RYBP TFIP11 WEE2-AS1 ZRANB2
Entrez ID		23429	10112
HPRD ID		09607	09292
Ensembl ID		ENSG00000163602	ENSG00000112984
Uniprot IDs		Q8N488	O95235
PDB IDs		3IXS 8PP6 9DBY 9DDE 9DG3	6YIP
Enriched GO Terms of Interacting Partners?		Nucleus PcG Protein Complex Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Death Effector Domain Binding Nucleoplasm Ripoptosome CD95 Death-inducing Signaling Complex Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process PRC1 Complex Positive Regulation Of Execution Phase Of Apoptosis Transcription Regulator Complex Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Ubiquitin Protein Ligase Binding Protein Ubiquitination Positive Regulation Of Transcription By RNA Polymerase II Response To Hydrogen Peroxide Post-translational Protein Modification Receptor Serine/threonine Kinase Binding Positive Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Death-inducing Signaling Complex Sex Chromatin Protein Binding Protein Modification By Small Protein Conjugation Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Metabolic Process Nuclear Body TRAIL-activated Apoptotic Signaling Pathway Regulation Of T Cell Migration RNA Polymerase II Transcription Regulator Complex Protein-containing Complex Postsynaptic Specialization Assembly Proteasome Complex Macromolecule Metabolic Process Chromatin Organization Response To UV-C Response To Reactive Oxygen Species Regulation Of Lymphocyte Migration	Protein Localization To Golgi Membrane Myosin V Binding Protein Localization To Golgi Apparatus Intra-Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Peptidyl-cysteine Methylation Retrograde Transport, Endosome To Golgi GTP Binding Endosome To Plasma Membrane Transport Vesicle Kinociliary Basal Body RNA Splicing Spliceosomal Complex Disassembly U2-type Post-mRNA Release Spliceosomal Complex
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