RYBP and PADI4

Number of citations of the paper that reports this interaction (PubMedID 37399862)
0

Data Source:
BioGRID (imaging technique, pull down)

		RYBP	PADI4
Description		RING1 and YY1 binding protein	peptidyl arginine deiminase 4
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm PcG Protein Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex
	Molecular Function	Nucleic Acid Binding DNA Binding Transcription Coregulator Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Metal Ion Binding	Protein-arginine Deiminase Activity Calcium Ion Binding Protein Binding Hydrolase Activity Identical Protein Binding Metal Ion Binding Histone Arginine Deiminase Activity Histone H3R2 Arginine Deiminase Activity Histone H3R8 Arginine Deiminase Activity Histone H3R17 Arginine Deiminase Activity Histone H3R26 Arginine Deiminase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Remodeling Regulation Of DNA-templated Transcription Apoptotic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of DNA-templated Transcription	Immune System Process Chromatin Organization Nucleosome Assembly Chromatin Remodeling Stem Cell Population Maintenance Protein Modification Process Post-translational Protein Modification Innate Immune Response
Pathways		RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Transcriptional Regulation by E2F6	Chromatin modifying enzymes
Drugs			Citrulline Azithromycin Tetracycline Streptomycin N-[(1S)-1-(aminocarbonyl)-4-(ethanimidoylamino)butyl]benzamide Chlortetracycline
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 32296059) Body size at age 10 ( 32376654) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Height ( 23563607 31562340 28552196 25429064 25282103 20881960) Hip circumference adjusted for BMI ( 34021172) Medication use (beta blocking agents) ( 31015401) Metabolite levels ( 23823483) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309) Resting-state electroencephalogram vigilance ( 29703947) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28448500 25673412 34021172)	Autoimmune traits (pleiotropy) ( 30572963) Basal cell carcinoma ( 18849993) Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) IgA nephropathy ( 25305756 32912934) Rheumatoid arthritis ( 21452313 21505073 23143596 24390342 30423114 30572963 32723749) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676)
Interacting Genes		38 interacting genes: ABL1 BANP CASP10 CASP8 CBX2 CRK E2F2 E2F3 E2F4 E2F6 EAF1 FADD FANK1 FHL3 GABPB1 GABPB2 HSPB1 KIF20A KPNA4 MAPK8IP2 MDM2 NMI NOS1AP PADI4 PRPF6 PSMB1 PTEN RBBP4 RING1 RNF2 RNF8 SOCS2 UBC UBE3A XAGE1A XAGE1B YY1 ZFP42	12 interacting genes: ANXA4 APP FBXO25 H3C15 HDAC2 LRRK2 MDM2 NPM1 POU6F2 RYBP SMURF1 TRIB3
Entrez ID		23429	23569
HPRD ID		09607	05635
Ensembl ID		ENSG00000163602	ENSG00000159339
Uniprot IDs		Q8N488	Q9UM07
PDB IDs		3IXS 8PP6 9DBY 9DDE 9DG3	1WD8 1WD9 1WDA 2DEW 2DEX 2DEY 2DW5 3APM 3APN 3B1T 3B1U 4DKT 4X8C 4X8G 5N0M 5N0Y 5N0Z 5N1B 8GOD 8R8U 8R8V 8SMK 8SML
Enriched GO Terms of Interacting Partners?		Nucleus PcG Protein Complex Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Death Effector Domain Binding Nucleoplasm Ripoptosome CD95 Death-inducing Signaling Complex Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process PRC1 Complex Positive Regulation Of Execution Phase Of Apoptosis Transcription Regulator Complex Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Ubiquitin Protein Ligase Binding Protein Ubiquitination Positive Regulation Of Transcription By RNA Polymerase II Response To Hydrogen Peroxide Post-translational Protein Modification Receptor Serine/threonine Kinase Binding Positive Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Death-inducing Signaling Complex Sex Chromatin Protein Binding Protein Modification By Small Protein Conjugation Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Metabolic Process Nuclear Body TRAIL-activated Apoptotic Signaling Pathway Regulation Of T Cell Migration RNA Polymerase II Transcription Regulator Complex Protein-containing Complex Postsynaptic Specialization Assembly Proteasome Complex Macromolecule Metabolic Process Chromatin Organization Response To UV-C Response To Reactive Oxygen Species Regulation Of Lymphocyte Migration	Positive Regulation Of Proteolysis Regulation Of Proteolysis Negative Regulation Of Signal Transduction Cellular Response To Catecholamine Stimulus Response To Catecholamine Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Metabolic Process NF-kappaB Binding Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Chromatin Remodeling Regulation Of Protein Catabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Dopamine Regulation Of Macromolecule Metabolic Process Response To Dopamine Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Proteasomal Protein Catabolic Process Cellular Response To Manganese Ion Negative Regulation Of Biosynthetic Process Positive Regulation Of Protein Catabolic Process Regulation Of Gene Expression Regulation Of Signal Transduction Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of RNA Biosynthetic Process Chromatin Organization Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Manganese Ion Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Catabolic Process Golgi-associated Vesicle Regulation Of Apoptotic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Ubiquitination Positive Regulation Of Tumor Necrosis Factor Production Regulation Of RNA Metabolic Process Cellular Response To Reactive Oxygen Species Regulation Of Programmed Cell Death
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