RYBP and XAGE1A

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RYBP	XAGE1A
Description		RING1 and YY1 binding protein	X antigen family member 1A
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm PcG Protein Complex
	Molecular Function	Nucleic Acid Binding DNA Binding Transcription Coregulator Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Metal Ion Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Remodeling Regulation Of DNA-templated Transcription Apoptotic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of DNA-templated Transcription
Pathways		RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Transcriptional Regulation by E2F6
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 32296059) Body size at age 10 ( 32376654) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Height ( 23563607 31562340 28552196 25429064 25282103 20881960) Hip circumference adjusted for BMI ( 34021172) Medication use (beta blocking agents) ( 31015401) Metabolite levels ( 23823483) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309) Resting-state electroencephalogram vigilance ( 29703947) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28448500 25673412 34021172)
Interacting Genes		38 interacting genes: ABL1 BANP CASP10 CASP8 CBX2 CRK E2F2 E2F3 E2F4 E2F6 EAF1 FADD FANK1 FHL3 GABPB1 GABPB2 HSPB1 KIF20A KPNA4 MAPK8IP2 MDM2 NMI NOS1AP PADI4 PRPF6 PSMB1 PTEN RBBP4 RING1 RNF2 RNF8 SOCS2 UBC UBE3A XAGE1A XAGE1B YY1 ZFP42	3 interacting genes: RYBP TSPYL2 YY1
Entrez ID		23429	653220
HPRD ID		09607	19214
Ensembl ID		ENSG00000163602	ENSG00000204379
Uniprot IDs		Q8N488	Q9HD64
PDB IDs		3IXS 8PP6 9DBY 9DDE 9DG3
Enriched GO Terms of Interacting Partners?		Nucleus PcG Protein Complex Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Death Effector Domain Binding Nucleoplasm Ripoptosome CD95 Death-inducing Signaling Complex Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process PRC1 Complex Positive Regulation Of Execution Phase Of Apoptosis Transcription Regulator Complex Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Ubiquitin Protein Ligase Binding Protein Ubiquitination Positive Regulation Of Transcription By RNA Polymerase II Response To Hydrogen Peroxide Post-translational Protein Modification Receptor Serine/threonine Kinase Binding Positive Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Death-inducing Signaling Complex Sex Chromatin Protein Binding Protein Modification By Small Protein Conjugation Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Metabolic Process Nuclear Body TRAIL-activated Apoptotic Signaling Pathway Regulation Of T Cell Migration RNA Polymerase II Transcription Regulator Complex Protein-containing Complex Postsynaptic Specialization Assembly Proteasome Complex Macromolecule Metabolic Process Chromatin Organization Response To UV-C Response To Reactive Oxygen Species Regulation Of Lymphocyte Migration	PcG Protein Complex Chromatin Remodeling Regulation Of DNA Replication Chromatin Organization Negative Regulation Of Cell Growth Immunoglobulin Heavy Chain V-D-J Recombination Negative Regulation Of Growth Response To Prostaglandin F Negative Regulation Of Nucleobase-containing Compound Metabolic Process RDNA Binding Regulation Of DNA Metabolic Process Regulation Of Cell Growth Regulation Of DNA Strand Elongation Chromatin Binding Negative Regulation Of Interferon-beta Production DNA-binding Transcription Repressor Activity Immunoglobulin V(D)J Recombination Ino80 Complex Positive Regulation Of Telomere Maintenance In Response To DNA Damage Response To UV-C Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Chromatin Silencing Complex V(D)J Recombination Four-way Junction DNA Binding Negative Regulation Of Macromolecule Metabolic Process Regulation Of Growth Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Negative Regulation Of Metabolic Process Negative Regulation Of Cardiac Muscle Tissue Growth Negative Regulation Of DNA Replication Camera-type Eye Morphogenesis Negative Regulation Of MiRNA Transcription RNA Localization Somatic Recombination Of Immunoglobulin Gene Segments Negative Regulation Of Organ Growth Negative Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Muscle Hypertrophy Negative Regulation Of Striated Muscle Cell Differentiation Somatic Cell DNA Recombination Somatic Diversification Of Immunoglobulins Negative Regulation Of Type I Interferon Production Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process SMAD Binding
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