RYBP and E2F6

Number of citations of the paper that reports this interaction (PMID 11171983)
70

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		RYBP	E2F6
Gene Name		RING1 and YY1 binding protein	E2F transcription factor 6
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm PcG Protein Complex	Nucleus Transcription Factor Complex MLL1 Complex
	Molecular Function	DNA Binding Transcription Corepressor Activity Protein Binding Zinc Ion Binding	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Apoptotic Process Multicellular Organismal Development Histone H2A Monoubiquitination	Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated
Pathways
Drugs
Diseases
GWAS		Height ( 20881960 23563607)	Sudden cardiac arrest ( 21658281)
Protein-Protein Interactions		17 interactors: ABL1 CASP10 CASP8 CBX2 E2F2 E2F3 E2F4 E2F6 FADD GABPB1 GABPB2 MDM2 RING1 RNF2 SOCS2 YY1 ZFP42	14 interactors: APP ARAF BMI1 E2F1 EPC1 EZH1 EZH2 KRTAP10-7 PCGF6 RING1 RYBP TFDP1 TFDP2 ZMYND11
Entrez ID		23429	1876
HPRD ID		09607	04251
Ensembl ID			ENSG00000169016
Uniprot IDs		Q8N488	G5E936 O75461 Q53YM3 Q6Q9Z5 Q6Q9Z6
PDB IDs		3IXS
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Mitotic Cell Cycle Regulation Of Transcription From RNA Polymerase II Promoter TRAIL-activated Apoptotic Signaling Pathway RNA Metabolic Process Cell Cycle Gene Expression Apoptotic Signaling Pathway Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Cellular Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To UV-C Histone H2A Monoubiquitination Positive Regulation Of Macrophage Differentiation Negative Regulation Of Necroptotic Process Apoptotic Process Negative Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process Programmed Cell Death Negative Regulation Of Necrotic Cell Death Histone H2A Ubiquitination Positive Regulation Of Gene Expression Regulation Of Necroptotic Process Cell Death Death Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Histone Monoubiquitination Metabolic Process Organelle Organization Regulation Of Necrotic Cell Death Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Cellular Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter	Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription RNA Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Gene Expression Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Chromatin Modification Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Histone Modification Nucleobase-containing Compound Metabolic Process Chromatin Organization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Gene Expression Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Chromosome Organization Histone Ubiquitination Notch Signaling Pathway Biosynthetic Process Anoikis Peptidyl-lysine Modification Histone H3-K27 Methylation Positive Regulation Of Cellular Metabolic Process Cellular Metabolic Process Histone H2A Monoubiquitination Histone H2A Ubiquitination Histone Monoubiquitination Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Cellular Protein Modification Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Cellular Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Transcription Elongation From RNA Polymerase II Promoter Regulation Of Gene Expression, Epigenetic
Tagcloud ?		3p amplifications breeding classic consuming cooperates costly daunting drive drivers driving endogenously engineering faithful foxp1 hidden incurable pc pten ptenloxp rapidcap recreate reside sensitized shq1 trp53 trp53loxp unmet validation	193a accumulating alters attenuate bimodal cd117 cd44 chemoresistance competition complexity conjecture constitute dataset experimentally initiating kit mathematical microrna namely ocic ovarian persistence picture polycomb predicts switching tcga unravel ways
Tagcloud (Difference) ?		3p amplifications breeding classic consuming cooperates costly daunting drive drivers driving endogenously engineering faithful foxp1 hidden incurable pc pten ptenloxp rapidcap recreate reside sensitized shq1 trp53 trp53loxp unmet validation	193a accumulating alters attenuate bimodal cd117 cd44 chemoresistance competition complexity conjecture constitute dataset experimentally initiating kit mathematical microrna namely ocic ovarian persistence picture polycomb predicts switching tcga unravel ways
Tagcloud (Intersection) ?