RYBP and SOCS2

Number of citations of the paper that reports this interaction (PubMedID 20543098)
0

Data Source:
BioGRID (two hybrid)

		RYBP	SOCS2
Description		RING1 and YY1 binding protein	suppressor of cytokine signaling 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm PcG Protein Complex	Cytoplasm Cytosol Cul5-RING Ubiquitin Ligase Complex
	Molecular Function	Nucleic Acid Binding DNA Binding Transcription Coregulator Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Metal Ion Binding	Cytokine Receptor Binding Growth Hormone Receptor Binding Insulin-like Growth Factor Receptor Binding Protein Binding JAK Pathway Signal Transduction Adaptor Activity Phosphorylation-dependent Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Remodeling Regulation Of DNA-templated Transcription Apoptotic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of DNA-templated Transcription	Regulation Of Cell Growth Cell Surface Receptor Signaling Pathway Via JAK-STAT Lactation Regulation Of Signal Transduction Negative Regulation Of Signal Transduction Protein Ubiquitination Cytokine-mediated Signaling Pathway Response To Estradiol Cellular Response To Hormone Stimulus Intracellular Signal Transduction Erythropoietin-mediated Signaling Pathway Regulation Of Multicellular Organism Growth Negative Regulation Of Multicellular Organism Growth Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Neuron Differentiation Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Growth Hormone Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Growth Hormone Receptor Signaling Pathway Mammary Gland Alveolus Development
Pathways		RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Transcriptional Regulation by E2F6	Interleukin-7 signaling Neddylation Negative regulation of FLT3 Growth hormone receptor signaling
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 32296059) Body size at age 10 ( 32376654) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Height ( 23563607 31562340 28552196 25429064 25282103 20881960) Hip circumference adjusted for BMI ( 34021172) Medication use (beta blocking agents) ( 31015401) Metabolite levels ( 23823483) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309) Resting-state electroencephalogram vigilance ( 29703947) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28448500 25673412 34021172)	Height ( 18391951 18391952 20881960 23563607 25282103 25429064 28552196 31562340) Hepatic lipid content in extreme obesity ( 25246029) Hip circumference adjusted for BMI ( 34021172) Joint damage in rheumatoid arthritis ( 31596875) Pubertal anthropometrics ( 23449627) Type 2 diabetes ( 30054458)
Interacting Genes		38 interacting genes: ABL1 BANP CASP10 CASP8 CBX2 CRK E2F2 E2F3 E2F4 E2F6 EAF1 FADD FANK1 FHL3 GABPB1 GABPB2 HSPB1 KIF20A KPNA4 MAPK8IP2 MDM2 NMI NOS1AP PADI4 PRPF6 PSMB1 PTEN RBBP4 RING1 RNF2 RNF8 SOCS2 UBC UBE3A XAGE1A XAGE1B YY1 ZFP42	21 interacting genes: ARFIP2 BMI1 EGFR EPOR ERBB3 ERBB4 GHR IGF1R INSR JAK1 JAK3 KIT MET PLA2G1B PRLR PTK2 RYBP SOCS3 STK16 TPD52 YES1
Entrez ID		23429	8835
HPRD ID		09607	05490
Ensembl ID		ENSG00000163602	ENSG00000120833
Uniprot IDs		Q8N488	O14508
PDB IDs		3IXS 8PP6 9DBY 9DDE 9DG3	2C9W 4JGH 5BO4 6I4X 6I5J 6I5N 7M6T 7ZLM 7ZLN 7ZLO 7ZLP 7ZLR 7ZLS
Enriched GO Terms of Interacting Partners?		Nucleus PcG Protein Complex Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Death Effector Domain Binding Nucleoplasm Ripoptosome CD95 Death-inducing Signaling Complex Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process PRC1 Complex Positive Regulation Of Execution Phase Of Apoptosis Transcription Regulator Complex Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Ubiquitin Protein Ligase Binding Protein Ubiquitination Positive Regulation Of Transcription By RNA Polymerase II Response To Hydrogen Peroxide Post-translational Protein Modification Receptor Serine/threonine Kinase Binding Positive Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Death-inducing Signaling Complex Sex Chromatin Protein Binding Protein Modification By Small Protein Conjugation Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Metabolic Process Nuclear Body TRAIL-activated Apoptotic Signaling Pathway Regulation Of T Cell Migration RNA Polymerase II Transcription Regulator Complex Protein-containing Complex Postsynaptic Specialization Assembly Proteasome Complex Macromolecule Metabolic Process Chromatin Organization Response To UV-C Response To Reactive Oxygen Species Regulation Of Lymphocyte Migration	Protein Tyrosine Kinase Activity Protein Kinase Activity Receptor Complex Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Protein Phosphorylation Phosphorylation Protein Phosphatase Binding Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cell Population Proliferation Cell Surface Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Signaling Pathway Via STAT ATP Binding Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Programmed Cell Death Negative Regulation Of Programmed Cell Death Peptidyl-tyrosine Phosphorylation Protein Autophosphorylation Nucleotide Binding Transferase Activity Growth Hormone Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of MAPK Cascade Protein Modification Process Regulation Of Cell Population Proliferation Regulation Of Multicellular Organismal Process Positive Regulation Of Multicellular Organismal Process Phosphate-containing Compound Metabolic Process Regulation Of Apoptotic Process Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Growth Hormone Receptor Signaling Pathway Via JAK-STAT Cell Differentiation Regulation Of MAPK Cascade Protein Tyrosine Kinase Activator Activity Cellular Developmental Process Epidermal Growth Factor Receptor Signaling Pathway Protein Metabolic Process Positive Regulation Of Metabolic Process Basal Plasma Membrane Regulation Of Signal Transduction Positive Regulation Of Phosphate Metabolic Process ERBB Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process
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