RYBP and EAF1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RYBP	EAF1
Description		RING1 and YY1 binding protein	ELL associated factor 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm PcG Protein Complex	Nucleus Nucleoplasm Transcription Elongation Factor Complex Cajal Body Nuclear Body Nuclear Speck Super Elongation Complex Intercellular Bridge
	Molecular Function	Nucleic Acid Binding DNA Binding Transcription Coregulator Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Metal Ion Binding	Transcription Elongation Factor Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Remodeling Regulation Of DNA-templated Transcription Apoptotic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of DNA-templated Transcription	Transcription Elongation By RNA Polymerase II Regulation Of Transcription Elongation By RNA Polymerase II
Pathways		RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Transcriptional Regulation by E2F6	Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 32296059) Body size at age 10 ( 32376654) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Height ( 23563607 31562340 28552196 25429064 25282103 20881960) Hip circumference adjusted for BMI ( 34021172) Medication use (beta blocking agents) ( 31015401) Metabolite levels ( 23823483) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309) Resting-state electroencephalogram vigilance ( 29703947) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28448500 25673412 34021172)
Interacting Genes		38 interacting genes: ABL1 BANP CASP10 CASP8 CBX2 CRK E2F2 E2F3 E2F4 E2F6 EAF1 FADD FANK1 FHL3 GABPB1 GABPB2 HSPB1 KIF20A KPNA4 MAPK8IP2 MDM2 NMI NOS1AP PADI4 PRPF6 PSMB1 PTEN RBBP4 RING1 RNF2 RNF8 SOCS2 UBC UBE3A XAGE1A XAGE1B YY1 ZFP42	54 interacting genes: AP2M1 APP ARID4B BEND7 CCDC150 CCDC33 CDK9 CEP70 CEP76 DNTTIP1 DPPA4 DRC4 ELL ELL2 FAM228A GADD45GIP1 GCSAML GOLGA6L9 GPRASP3 GRHL3 GTF2H1 GTF2H4 HOMER3 HSF2BP KEAP1 KIAA1328 MAB21L3 MIPOL1 NUMB PAX6 PICK1 PIH1D1 PSME3 RYBP SDCBP SEMG1 SH3RF1 SRP14 STAC3 TCEA2 TFCP2 TFPT TLE5 TNFAIP8 TNNI1 TRAF2 TRIM28 TRIM62 VAX1 YAF2 ZBTB14 ZNF143 ZNF202 ZNF620
Entrez ID		23429	85403
HPRD ID		09607	12209
Ensembl ID		ENSG00000163602	ENSG00000144597
Uniprot IDs		Q8N488	Q96JC9
PDB IDs		3IXS 8PP6 9DBY 9DDE 9DG3	7OKX 7OKY
Enriched GO Terms of Interacting Partners?		Nucleus PcG Protein Complex Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Death Effector Domain Binding Nucleoplasm Ripoptosome CD95 Death-inducing Signaling Complex Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process PRC1 Complex Positive Regulation Of Execution Phase Of Apoptosis Transcription Regulator Complex Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Ubiquitin Protein Ligase Binding Protein Ubiquitination Positive Regulation Of Transcription By RNA Polymerase II Response To Hydrogen Peroxide Post-translational Protein Modification Receptor Serine/threonine Kinase Binding Positive Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Death-inducing Signaling Complex Sex Chromatin Protein Binding Protein Modification By Small Protein Conjugation Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Metabolic Process Nuclear Body TRAIL-activated Apoptotic Signaling Pathway Regulation Of T Cell Migration RNA Polymerase II Transcription Regulator Complex Protein-containing Complex Postsynaptic Specialization Assembly Proteasome Complex Macromolecule Metabolic Process Chromatin Organization Response To UV-C Response To Reactive Oxygen Species Regulation Of Lymphocyte Migration	Transcription By RNA Polymerase II DNA-templated Transcription Transcription Elongation Factor Complex Protein Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Receptor Internalization TORC1 Complex Assembly Regulation Of RNA Metabolic Process Transcription Elongation By RNA Polymerase II DNA-templated Transcription Elongation Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA Binding Regulation Of Receptor-mediated Endocytosis Nucleoplasm Regulation Of Nucleobase-containing Compound Metabolic Process Nucleobase-containing Compound Biosynthetic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Receptor Internalization Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Elongation Neuroblast Proliferation SnRNA Transcription By RNA Polymerase II Positive Regulation Of Receptor-mediated Endocytosis Transcription Factor TFIIH Core Complex Regulation Of Macromolecule Metabolic Process Transcription Factor TFIIH Holo Complex Negative Regulation Of Neuroblast Proliferation Nucleus Positive Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process SnRNA Transcription Regulation Of Gene Expression Chromatin Remodeling Positive Regulation Of DNA-templated Transcription, Elongation RNA Metabolic Process Positive Regulation Of Metabolic Process Regulation Of JNK Cascade Regulation Of Macromolecule Biosynthetic Process Central Nervous System Development Regulation Of Proteolysis Positive Regulation Of Transcription By RNA Polymerase III
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