RYBP and CBX2

Number of citations of the paper that reports this interaction (PMID 10369680)
44

Data Source:
HPRD (in vivo, in vitro)

		RYBP	CBX2
Gene Name		RING1 and YY1 binding protein	chromobox homolog 2
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm PcG Protein Complex	Euchromatin Heterochromatin Nucleus Nucleoplasm PcG Protein Complex PRC1 Complex
	Molecular Function	DNA Binding Transcription Corepressor Activity Protein Binding Zinc Ion Binding	DNA Binding Chromatin Binding Protein Binding Methylated Histone Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Apoptotic Process Multicellular Organismal Development Histone H2A Monoubiquitination	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Chromatin Modification Cell Differentiation Development Of Primary Sexual Characteristics
Pathways			Oxidative Stress Induced Senescence Cellular Senescence
Drugs
Diseases
GWAS		Height ( 20881960 23563607)
Protein-Protein Interactions		17 interactors: ABL1 CASP10 CASP8 CBX2 E2F2 E2F3 E2F4 E2F6 FADD GABPB1 GABPB2 MDM2 RING1 RNF2 SOCS2 YY1 ZFP42	12 interactors: DHX57 HIST3H3 KRTAP10-1 KRTAP10-3 KRTAP10-7 KRTAP10-9 KRTAP2-4 KRTAP4-12 MDFI RBMY1A1 RBMY1F RYBP
Entrez ID		23429	84733
HPRD ID		09607	14397
Ensembl ID			ENSG00000173894
Uniprot IDs		Q8N488	Q14781
PDB IDs		3IXS	2D9U 3H91
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Mitotic Cell Cycle Regulation Of Transcription From RNA Polymerase II Promoter TRAIL-activated Apoptotic Signaling Pathway RNA Metabolic Process Cell Cycle Gene Expression Apoptotic Signaling Pathway Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Cellular Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To UV-C Histone H2A Monoubiquitination Positive Regulation Of Macrophage Differentiation Negative Regulation Of Necroptotic Process Apoptotic Process Negative Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process Programmed Cell Death Negative Regulation Of Necrotic Cell Death Histone H2A Ubiquitination Positive Regulation Of Gene Expression Regulation Of Necroptotic Process Cell Death Death Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Histone Monoubiquitination Metabolic Process Organelle Organization Regulation Of Necrotic Cell Death Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Cellular Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter	RNA Processing
Tagcloud ?		3p amplifications breeding classic consuming cooperates costly daunting drive drivers driving endogenously engineering faithful foxp1 hidden incurable pc pten ptenloxp rapidcap recreate reside sensitized shq1 trp53 trp53loxp unmet validation	aberrations addressing averaged cdkn2a chromobox cosmic databases discovered exceeded genotranscriptomic inactivating modifiers neoplasms never oncogenic oncomine pcg polycomb rationale silence spanning suggestive tendency transcriptionally transcriptomic tumours unbiased uncharacterised widespread
Tagcloud (Difference) ?		3p amplifications breeding classic consuming cooperates costly daunting drive drivers driving endogenously engineering faithful foxp1 hidden incurable pc pten ptenloxp rapidcap recreate reside sensitized shq1 trp53 trp53loxp unmet validation	aberrations addressing averaged cdkn2a chromobox cosmic databases discovered exceeded genotranscriptomic inactivating modifiers neoplasms never oncogenic oncomine pcg polycomb rationale silence spanning suggestive tendency transcriptionally transcriptomic tumours unbiased uncharacterised widespread
Tagcloud (Intersection) ?