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THBS1 and COL3A1
Number of citations of the paper that reports this interaction (PubMedID
3571333
)
41
Data Source:
HPRD
(in vitro)
THBS1
COL3A1
Description
thrombospondin 1
collagen type III alpha 1 chain
Image
GO Annotations
Cellular Component
Extracellular Region
Fibrinogen Complex
Extracellular Space
Endoplasmic Reticulum
Endoplasmic Reticulum Lumen
External Side Of Plasma Membrane
Cell Surface
Sarcoplasmic Reticulum
Secretory Granule
Extracellular Matrix
Platelet Alpha Granule
Platelet Alpha Granule Lumen
Extracellular Exosome
Extracellular Region
Collagen Trimer
Fibrillar Collagen Trimer
Collagen Type III Trimer
Extracellular Space
Endoplasmic Reticulum Lumen
Extracellular Matrix
Molecular Function
Phosphatidylserine Binding
Fibronectin Binding
Protease Binding
Endopeptidase Inhibitor Activity
Integrin Binding
Extracellular Matrix Structural Constituent
Calcium Ion Binding
Protein Binding
Heparin Binding
Fibroblast Growth Factor Binding
Low-density Lipoprotein Particle Binding
Protein Homodimerization Activity
Laminin Binding
Proteoglycan Binding
Transforming Growth Factor Beta Binding
Extracellular Matrix Binding
Fibrinogen Binding
Collagen V Binding
Protease Binding
Integrin Binding
Extracellular Matrix Structural Constituent
Protein Binding
Extracellular Matrix Structural Constituent Conferring Tensile Strength
SMAD Binding
Metal Ion Binding
Platelet-derived Growth Factor Binding
Biological Process
Angiogenesis
Response To Hypoxia
Negative Regulation Of Endothelial Cell Proliferation
Negative Regulation Of Cell-matrix Adhesion
Sprouting Angiogenesis
Chronic Inflammatory Response
Negative Regulation Of Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II
Negative Regulation Of Dendritic Cell Antigen Processing And Presentation
Positive Regulation Of Immune System Process
Apoptotic Process
Inflammatory Response
Immune Response
Response To Unfolded Protein
Cell Adhesion
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Response To Xenobiotic Stimulus
Response To Mechanical Stimulus
Response To Glucose
Positive Regulation Of Endothelial Cell Migration
Negative Regulation Of Endothelial Cell Migration
Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane
Negative Regulation Of Nitric Oxide Mediated Signal Transduction
Negative Regulation Of CGMP-mediated Signaling
Negative Regulation Of Plasminogen Activation
Positive Regulation Of Macrophage Chemotaxis
Positive Regulation Of Fibroblast Migration
Regulation Of Cell-substrate Adhesion
Cell Migration
Negative Regulation Of Angiogenesis
Positive Regulation Of Cell Migration
Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Response To Magnesium Ion
Response To Progesterone
Negative Regulation Of Interleukin-10 Production
Negative Regulation Of Interleukin-12 Production
Negative Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Transforming Growth Factor Beta1 Production
Response To Testosterone
Cellular Response To Heat
Response To Endoplasmic Reticulum Stress
Nitric Oxide-cGMP-mediated Signaling
Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway
Positive Regulation Of Phosphorylation
Positive Regulation Of Macrophage Activation
Negative Regulation Of Apoptotic Process
Positive Regulation Of MAPK Cascade
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Negative Regulation Of Blood Vessel Endothelial Cell Migration
Engulfment Of Apoptotic Cell
Positive Regulation Of Translation
Positive Regulation Of Angiogenesis
Behavioral Response To Pain
Blood Vessel Morphogenesis
Positive Regulation Of Smooth Muscle Cell Proliferation
Positive Regulation Of Chemotaxis
Response To Calcium Ion
Negative Regulation Of Focal Adhesion Assembly
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Negative Regulation Of Fibrinolysis
Cellular Response To Tumor Necrosis Factor
Cellular Response To Growth Factor Stimulus
Positive Regulation Of Transforming Growth Factor Beta Production
Blood Coagulation, Fibrin Clot Formation
Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Negative Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis
Negative Regulation Of Sprouting Angiogenesis
Positive Regulation Of Endothelial Cell Apoptotic Process
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Negative Regulation Of Endothelial Cell Chemotaxis
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Blood Vessel Development
In Utero Embryonic Development
Neuron Migration
Tissue Homeostasis
Chondrocyte Differentiation
Cell-matrix Adhesion
Transforming Growth Factor Beta Receptor Signaling Pathway
Integrin-mediated Signaling Pathway
Heart Development
Response To Radiation
Gene Expression
Peptide Cross-linking
Layer Formation In Cerebral Cortex
Cerebral Cortex Development
Platelet Activation
Extracellular Matrix Organization
Collagen Fibril Organization
Lung Development
Transforming Growth Factor Beta1 Production
Response To Cytokine
Positive Regulation Of Rho Protein Signal Transduction
Multicellular Organism Growth
Aorta Development
Limb Joint Morphogenesis
Wound Healing
Skin Development
Fibroblast Proliferation
Elastic Fiber Assembly
Animal Organ Development
Digestive Tract Development
System Development
Negative Regulation Of Immune Response
Cartilage Development
Endochondral Bone Morphogenesis
Aorta Smooth Muscle Tissue Morphogenesis
Cellular Response To Amino Acid Stimulus
Basement Membrane Organization
Supramolecular Fiber Organization
Response To Angiotensin
Negative Regulation Of Neuron Migration
Pathways
Platelet degranulation
Signaling by PDGF
Integrin cell surface interactions
Syndecan interactions
Defective B3GALTL causes PpS
O-glycosylation of TSR domain-containing proteins
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Collagen degradation
Collagen degradation
Fibronectin matrix formation
Collagen biosynthesis and modifying enzymes
Signaling by PDGF
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Assembly of collagen fibrils and other multimeric structures
Integrin cell surface interactions
Syndecan interactions
Non-integrin membrane-ECM interactions
ECM proteoglycans
ECM proteoglycans
Scavenging by Class A Receptors
NCAM1 interactions
MET activates PTK2 signaling
Collagen chain trimerization
Developmental Lineage of Pancreatic Ductal Cells
Drugs
Collagenase clostridium histolyticum
Diseases
Ehlers-Danlos syndrome (EDS), including: EDS classical type (EDS1/2); EDS hypermobility type (EDS3); EDS vascular type (EDS4); EDS kyphoscoliosis type (EDS6); EDS arthrochalasia type (EDS7A/7B); EDS dermatospraxis type (EDS7C); EDS autosomal recessive cardiac valvular form (EDSCV); EDS musculocontractural type (EDSMC); EDS progeroid form (EDSP); Tenascin-X deficiency (TNXD); Brittle cornea syndrome (EDS6B); EDS-like spondylocheiro dysplasia (SCD-EDS)
GWAS
Cortical volume (
32963231
)
Liver enzyme levels (alanine transaminase) (
33972514
)
Logical memory (immediate recall) in normal cognition (
29274321
)
Urate levels (
31578528
)
Brain morphology (min-P) (
32665545
)
Brain morphology (MOSTest) (
32665545
)
Carotid intima media thickness x smoking interaction (
32117412
)
Cortical surface area (MOSTest) (
32665545
)
Cortical thickness (MOSTest) (
32665545
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Parkinson disease and lewy body pathology (
25663231
)
Platelet distribution width (
32888494
)
Subcortical volume (min-P) (
32665545
)
Subcortical volume (MOSTest) (
32665545
)
Interacting Genes
52 interacting genes:
APP
BGN
CALCR
CALR
CD36
CD47
CFH
COL11A1
COL18A1
COL1A1
COL2A1
COL3A1
COL4A1
COL5A1
COL6A1
COL7A1
CORO1A
CTSG
DCN
DHFR
DYRK1A
ELANE
F2
FBN2
FGA
FGF2
FN1
HRG
HSP90AA1
IGFBP5
ITGB3
JAG1
KNG1
LAMB3
LRP1
LRP2
LRP5
MMP2
MMP9
MTDH
PDGFB
PLG
PLSCR1
SCARB2
SPARC
TFPI
TGFB1
TGM2
TNFAIP6
TNFRSF11B
WEE2-AS1
WWP2
14 interacting genes:
AP2B1
CAPN1
DDR1
DDR2
FGF7
HTRA1
MAG
MYOC
PCOLCE
PDGFA
PDGFB
SPARC
THBS1
VWF
Entrez ID
7057
1281
HPRD ID
01765
00365
Ensembl ID
ENSG00000137801
ENSG00000168542
Uniprot IDs
P07996
A0AAG2UVC5
P02461
PDB IDs
1LSL
1UX6
1Z78
1ZA4
2ERF
2ES3
2OUH
2OUJ
3R6B
5FOE
7YYK
2V53
3DMW
4AE2
4AEJ
4AK3
4GYX
6FZV
6FZW
7WWR
7WWS
7XAN
Enriched GO Terms of Interacting Partners
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Extracellular Matrix
Extracellular Region
Extracellular Space
Endoplasmic Reticulum Lumen
Platelet-derived Growth Factor Binding
Extracellular Matrix Organization
Extracellular Structure Organization
Extracellular Matrix Structural Constituent
Extracellular Matrix Structural Constituent Conferring Tensile Strength
Regulation Of Cell Migration
Regulation Of Multicellular Organismal Process
Regulation Of Cell Motility
Regulation Of Locomotion
Platelet Alpha Granule Lumen
Regulation Of Cell Communication
Regulation Of Signaling
Negative Regulation Of Multicellular Organismal Process
Collagen Trimer
Regulation Of Signal Transduction
Positive Regulation Of Cell Migration
Basement Membrane
Positive Regulation Of Cell Motility
Endodermal Cell Differentiation
Regulation Of Cell Adhesion
Positive Regulation Of Locomotion
Fibrillar Collagen Trimer
Regulation Of Blood Coagulation
Negative Regulation Of Wound Healing
Heparin Binding
Regulation Of Hemostasis
Cell Surface
Negative Regulation Of Blood Coagulation
Negative Regulation Of Hemostasis
Anatomical Structure Formation Involved In Morphogenesis
Negative Regulation Of Coagulation
Tissue Remodeling
Positive Regulation Of Smooth Muscle Cell Proliferation
Regulation Of Wound Healing
Animal Organ Morphogenesis
Response To Wounding
Anatomical Structure Morphogenesis
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Blood Coagulation
Cell Surface Receptor Signaling Pathway
Coagulation
Regulation Of Cell-substrate Adhesion
Platelet Activation
Biological Process Involved In Interaction With Symbiont
Positive Regulation Of Multicellular Organismal Process
Hemostasis
Collagen Binding
Platelet Alpha Granule Lumen
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Extracellular Space
Extracellular Region
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Cell Migration
Positive Regulation Of Cell Motility
Positive Regulation Of Locomotion
Protein Tyrosine Kinase Collagen Receptor Activity
Response To Wounding
Platelet-derived Growth Factor Complex
Negative Regulation Of Phosphatidylinositol Biosynthetic Process
Platelet Alpha Granule
Extracellular Matrix
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Positive Regulation Of MAPK Cascade
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Cell Population Proliferation
Positive Regulation Of Phosphorylation
Positive Regulation Of Metanephric Mesenchymal Cell Migration
Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Extracellular Matrix Structural Constituent
Regulation Of Body Fluid Levels
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Phosphate Metabolic Process
Regulation Of Wound Healing
Regulation Of Cellular Component Organization
Negative Regulation Of Phospholipid Biosynthetic Process
Regulation Of Endothelial Cell Proliferation
Animal Organ Development
Regulation Of Cell Migration
Enzyme-linked Receptor Protein Signaling Pathway
Peptidyl-tyrosine Phosphorylation
Regulation Of Cell Motility
Regulation Of MAPK Cascade
Regulation Of Response To Wounding
Regulation Of Locomotion
Positive Regulation Of Fibroblast Proliferation
Positive Regulation Of Protein Autophosphorylation
Positive Regulation Of Signal Transduction
Regulation Of Branching Involved In Salivary Gland Morphogenesis
Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Regulation Of Phosphorylation
Regulation Of Blood Coagulation
Regulation Of Cell-substrate Adhesion
Regulation Of Hemostasis
Regulation Of Smooth Muscle Cell Migration
Collagen-activated Tyrosine Kinase Receptor Signaling Pathway
Regulation Of Signal Transduction
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