THBS1 and TNFAIP6

Number of citations: 99 (PubMedID 16006654)
Data Source: HPRD (in vitro)

		THBS1	TNFAIP6
Name		thrombospondin 1	TNF alpha induced protein 6
Structure
GO Annotations	Cellular Component	Extracellular Region Fibrinogen Complex Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen External Side Of Plasma Membrane Cell Surface Sarcoplasmic Reticulum Secretory Granule Extracellular Matrix Platelet Alpha Granule Platelet Alpha Granule Lumen Extracellular Exosome	Extracellular Region Extracellular Space Tertiary Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	Phosphatidylserine Binding Fibronectin Binding Protease Binding Endopeptidase Inhibitor Activity Integrin Binding Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Heparin Binding Fibroblast Growth Factor Binding Low-density Lipoprotein Particle Binding Protein Homodimerization Activity Laminin Binding Proteoglycan Binding Transforming Growth Factor Beta Binding Extracellular Matrix Binding Fibrinogen Binding Collagen V Binding	Fibronectin Binding Calcium Ion Binding Protein Binding Hyaluronic Acid Binding Hydrolase Activity Metal Ion Binding Carboxylesterase Activity
	Biological Process	Angiogenesis Response To Hypoxia Negative Regulation Of Endothelial Cell Proliferation Negative Regulation Of Cell-matrix Adhesion Sprouting Angiogenesis Chronic Inflammatory Response Negative Regulation Of Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Negative Regulation Of Dendritic Cell Antigen Processing And Presentation Positive Regulation Of Immune System Process Apoptotic Process Inflammatory Response Immune Response Response To Unfolded Protein Cell Adhesion Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Response To Mechanical Stimulus Response To Glucose Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Negative Regulation Of Nitric Oxide Mediated Signal Transduction Negative Regulation Of CGMP-mediated Signaling Negative Regulation Of Plasminogen Activation Positive Regulation Of Macrophage Chemotaxis Positive Regulation Of Fibroblast Migration Regulation Of Cell-substrate Adhesion Cell Migration Negative Regulation Of Angiogenesis Positive Regulation Of Cell Migration Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Response To Magnesium Ion Response To Progesterone Negative Regulation Of Interleukin-10 Production Negative Regulation Of Interleukin-12 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Transforming Growth Factor Beta1 Production Response To Testosterone Cellular Response To Heat Response To Endoplasmic Reticulum Stress Nitric Oxide-cGMP-mediated Signaling Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Phosphorylation Positive Regulation Of Macrophage Activation Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Blood Vessel Endothelial Cell Migration Engulfment Of Apoptotic Cell Positive Regulation Of Translation Positive Regulation Of Angiogenesis Behavioral Response To Pain Blood Vessel Morphogenesis Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Chemotaxis Response To Calcium Ion Negative Regulation Of Focal Adhesion Assembly Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Fibrinolysis Cellular Response To Tumor Necrosis Factor Cellular Response To Growth Factor Stimulus Positive Regulation Of Transforming Growth Factor Beta Production Blood Coagulation, Fibrin Clot Formation Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Negative Regulation Of Sprouting Angiogenesis Positive Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Endothelial Cell Chemotaxis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Ovarian Cumulus Expansion Inflammatory Response Cell Adhesion Signal Transduction Cell-cell Signaling Hyaluronan Metabolic Process Positive Regulation Of Cell Migration Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Osteoclast Differentiation Negative Regulation Of Inflammatory Response Negative Regulation Of Neutrophil Chemotaxis Positive Regulation Of Receptor Clustering Fibronectin Fibril Organization
Pathways		Platelet degranulation Signaling by PDGF Integrin cell surface interactions Syndecan interactions Defective B3GALTL causes PpS O-glycosylation of TSR domain-containing proteins RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	Neutrophil degranulation
Drugs		None	Donepezil Acetylsalicylic acid Hyaluronic acid
GWAS		Cortical volume ( 32963231 ) Liver enzyme levels (alanine transaminase) ( 33972514 ) Logical memory (immediate recall) in normal cognition ( 29274321 ) Urate levels ( 31578528 )	Blood protein levels ( 30072576 ) Lung cancer ( 23143601 )
Novel Interactors		2 novel interactors: KCNQ3 PLCB2	None recorded
Interacting Genes		52 interacting genes: APP BGN CALCR CALR CD36 CD47 CFH COL11A1 COL18A1 COL1A1 COL2A1 COL3A1 COL4A1 COL5A1 COL6A1 COL7A1 CORO1A CTSG DCN DHFR DYRK1A ELANE F2 FBN2 FGA FGF2 FN1 HRG HSP90AA1 IGFBP5 ITGB3 JAG1 KNG1 LAMB3 LRP1 LRP2 LRP5 MMP2 MMP9 MTDH PDGFB PLG PLSCR1 SCARB2 SPARC TFPI TGFB1 TGM2 TNFAIP6 TNFRSF11B WEE2-AS1 WWP2	3 interacting genes: ACAN THBS1 UBC
Entrez ID		7057	7130
HPRD ID		01765	02680
Ensembl ID		ENSG00000137801	ENSG00000123610
Uniprot IDs		P07996	P98066
PDB IDs		1LSL 1UX6 1Z78 1ZA4 2ERF 2ES3 2OUH 2OUJ 3R6B 5FOE 7YYK	1O7B 1O7C 2N40 2PF5 2WNO
GO Terms Enriched among Interactors		Extracellular Matrix Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Platelet-derived Growth Factor Binding Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Structural Constituent Extracellular Matrix Structural Constituent Conferring Tensile Strength Regulation Of Cell Migration Regulation Of Multicellular Organismal Process Regulation Of Cell Motility Regulation Of Locomotion Platelet Alpha Granule Lumen Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Multicellular Organismal Process Collagen Trimer Regulation Of Signal Transduction Positive Regulation Of Cell Migration Basement Membrane Positive Regulation Of Cell Motility Endodermal Cell Differentiation Regulation Of Cell Adhesion Positive Regulation Of Locomotion Fibrillar Collagen Trimer Regulation Of Blood Coagulation Negative Regulation Of Wound Healing Heparin Binding Regulation Of Hemostasis Cell Surface Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Anatomical Structure Formation Involved In Morphogenesis Negative Regulation Of Coagulation Tissue Remodeling Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of Wound Healing Animal Organ Morphogenesis Response To Wounding Anatomical Structure Morphogenesis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Blood Coagulation Cell Surface Receptor Signaling Pathway Coagulation Regulation Of Cell-substrate Adhesion Platelet Activation Biological Process Involved In Interaction With Symbiont Positive Regulation Of Multicellular Organismal Process Hemostasis	Extracellular Matrix Structural Constituent Conferring Compression Resistance Extracellular Matrix Perineuronal Net Extracellular Space Extracellular Matrix Structural Constituent Negative Regulation Of Endothelial Cell Chemotaxis Negative Regulation Of Dendritic Cell Antigen Processing And Presentation Negative Regulation Of Plasminogen Activation Negative Regulation Of Fibrinolysis Negative Regulation Of Nitric Oxide Mediated Signal Transduction Nitric Oxide-cGMP-mediated Signaling Chronic Inflammatory Response Negative Regulation Of Antigen Processing And Presentation Negative Regulation Of Fatty Acid Transport Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Collagen V Binding Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Transforming Growth Factor Beta1 Production Blood Coagulation, Fibrin Clot Formation Negative Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Negative Regulation Of Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Regulation Of CGMP-mediated Signaling Regulation Of Long-chain Fatty Acid Import Into Cell Fibrinogen Binding Fibrinogen Complex Proteoglycan Binding Engulfment Of Apoptotic Cell Negative Regulation Of CGMP-mediated Signaling Regulation Of Nitric Oxide Mediated Signal Transduction Hyaluronic Acid Binding Regulation Of Antigen Processing And Presentation Low-density Lipoprotein Particle Binding Fibroblast Growth Factor Binding Positive Regulation Of Transforming Growth Factor Beta Production Regulation Of Fibrinolysis Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Transforming Growth Factor Beta Binding Protein Activation Cascade Behavioral Response To Pain Negative Regulation Of Focal Adhesion Assembly Response To Magnesium Ion Positive Regulation Of Endothelial Cell Apoptotic Process Platelet Alpha Granule Laminin Binding Negative Regulation Of Sprouting Angiogenesis Nitric Oxide Mediated Signal Transduction Positive Regulation Of Macrophage Chemotaxis Negative Regulation Of Interleukin-12 Production Positive Regulation Of Fibroblast Migration Regulation Of Plasminogen Activation