TMPRSS6 and COL1A1

Number of citations of the paper that reports this interaction (PMID 12149247)
44

Data Source:
HPRD (in vitro)

		TMPRSS6	COL1A1
Gene Name		transmembrane protease, serine 6	collagen, type I, alpha 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane	Extracellular Region Collagen Type I Trimer Extracellular Space Endoplasmic Reticulum Lumen Golgi Apparatus Secretory Granule Extracellular Matrix
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding	Extracellular Matrix Structural Constituent Protein Binding Identical Protein Binding Metal Ion Binding Platelet-derived Growth Factor Binding
	Biological Process	Angiogenesis Proteolysis Extracellular Matrix Organization Negative Regulation Of BMP Signaling Pathway Intracellular Signal Transduction Fibrinolysis Iron Ion Homeostasis	Skeletal System Development Blood Vessel Development Osteoblast Differentiation Intramembranous Ossification Endochondral Ossification Receptor-mediated Endocytosis Blood Coagulation Visual Perception Sensory Perception Of Sound Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Cell-substrate Adhesion Protein Transport Extracellular Matrix Disassembly Platelet Activation Extracellular Matrix Organization Collagen Fibril Organization Positive Regulation Of Cell Migration Collagen Catabolic Process Response To Corticosteroid Response To Estradiol Collagen Biosynthetic Process Protein Localization To Nucleus Tooth Mineralization Response To Drug Response To Hydrogen Peroxide Response To Peptide Hormone Skin Morphogenesis Cellular Response To Fibroblast Growth Factor Stimulus Tooth Eruption Positive Regulation Of Transcription, DNA-templated Embryonic Skeletal System Development Leukocyte Migration Response To CAMP Response To Hyperoxia Face Morphogenesis Bone Trabecula Formation Cartilage Development Involved In Endochondral Bone Morphogenesis Protein Heterotrimerization Cellular Response To Amino Acid Stimulus Cellular Response To Mechanical Stimulus Cellular Response To Retinoic Acid Cellular Response To Vitamin E Cellular Response To Tumor Necrosis Factor Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Canonical Wnt Signaling Pathway Cellular Response To Fluoride
Pathways			Platelet Adhesion to exposed collagen Collagen formation Collagen degradation Anchoring fibril formation Non-integrin membrane-ECM interactions Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Cell surface interactions at the vascular wall Syndecan interactions Crosslinking of collagen fibrils ECM proteoglycans GPVI-mediated activation cascade Integrin cell surface interactions Collagen biosynthesis and modifying enzymes Platelet activation, signaling and aggregation Scavenging by Class A Receptors
Drugs			Collagenase
Diseases
GWAS		Glycated hemoglobin levels ( 20858683) Hematocrit ( 19862010) Hematological and biochemical traits ( 20139978) Hematological parameters ( 19820697) Hematology traits ( 23263863 19853236) Hemoglobin ( 19820698 19862010) Hepcidin levels ( 21785125) Iron levels ( 19880490 21208937) Iron status biomarkers ( 21149283 19820699 19084217) Mean corpuscular hemoglobin ( 23263863 20139978 19862010) Mean corpuscular hemoglobin concentration ( 23263863 20139978) Mean corpuscular volume ( 23263863 20139978 19862010) Red blood cell traits ( 20927387 23222517)	Breast cancer ( 17903305) Response to taxane treatment (docetaxel) ( 23006423)
Protein-Protein Interactions		3 interactors: COL1A1 FN1 LAMA1	37 interactors: ACHE ATP13A2 BARD1 BGN BMP1 BRCA1 CAPN1 CD36 CD44 CD93 COL7A1 DCN DDR2 FGF7 FN1 HTRA1 IGFBP3 ITGA2 ITGA5 MAG MATN2 MMP2 MMP9 NID1 NID2 P4HB PAK1 PDGFA PDGFB PKD1 PRELP SPARC TGFBI THBS1 TMPRSS6 TXN VWF
Entrez ID		164656	1277
HPRD ID		10270	00362
Ensembl ID		ENSG00000187045	ENSG00000108821
Uniprot IDs		Q8IU80	P02452
PDB IDs			1Q7D 2LLP 3EJH 3GXE
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Blood Vessel Development Vasculature Development Extracellular Matrix Disassembly Cardiovascular System Development Cellular Response To Fluoride Positive Regulation Of Cell Morphogenesis Involved In Differentiation Locomotion Platelet Activation Tooth Eruption Response To Fluoride Movement Of Cell Or Subcellular Component Leukocyte Migration Tissue Development Calcium-independent Cell-matrix Adhesion Retinal Blood Vessel Morphogenesis Cellular Response To Vitamin E Establishment Of Epithelial Cell Apical/basal Polarity Establishment Of Apical/basal Cell Polarity Polarized Epithelial Cell Differentiation Blood Coagulation Blood Vessel Morphogenesis Hemostasis Anatomical Structure Morphogenesis Regulation Of Cell Morphogenesis Establishment Of Monopolar Cell Polarity Intramembranous Ossification Tooth Mineralization Positive Regulation Of Cell Development Bone Trabecula Formation Protein Heterotrimerization Integrin Activation Retina Vasculature Morphogenesis In Camera-type Eye Collagen Biosynthetic Process Regulation Of Body Fluid Levels Regulation Of Cell Migration Wound Healing Regulation Of Cell Adhesion Regulation Of Cell Motility Establishment Of Epithelial Cell Polarity Bone Trabecula Morphogenesis Regulation Of Locomotion Cell Activation Response To Vitamin E Regulation Of Cellular Component Movement Response To Wounding Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Cell Morphogenesis Involved In Differentiation Retina Vasculature Development In Camera-type Eye	Extracellular Matrix Organization Extracellular Structure Organization Response To Wounding Extracellular Matrix Disassembly Wound Healing Multicellular Organismal Development Cell Adhesion Anatomical Structure Development Tissue Development Platelet Degranulation Developmental Process System Development Blood Coagulation Hemostasis Anatomical Structure Morphogenesis Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Regulation Of Cell Motility Positive Regulation Of Locomotion Positive Regulation Of Protein Metabolic Process Regulation Of Locomotion Regulation Of Cellular Amino Acid Metabolic Process Response To Stress Regulation Of Cellular Component Movement Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Body Fluid Levels Regulation Of Cell Migration Cell-substrate Adhesion Regulation Of Epithelial Cell Migration Regulation Of Cellular Ketone Metabolic Process Positive Regulation Of Phosphorylation Endodermal Cell Differentiation Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Phosphorylation Skeletal System Development Regulation Of Cellular Protein Metabolic Process Organ Development Blood Vessel Morphogenesis Regulation Of Phosphorus Metabolic Process Platelet Activation Organ Morphogenesis Locomotion Endoderm Formation Angiogenesis Regulation Of Protein Phosphorylation Regulation Of Phosphorylation Exocytosis
Tagcloud ?		addressed africa allele anaemia breastfeeding comparatively falciparum ferritin haematological haemoglobin hb household id income odds outweigh plasmodium preventable rs855791 rural rwanda rwandan saharan southern substantially tended thalassaemia uncommon verified	archive bcl6 cancerous cebpb checked cufflinks david deg degs downloaded exph5 fastqc hg19 msx2 noiseq paracancerous ppp2r2c read samtools sox4 srp009386 tophat totally transfa trp53 uniquely v1 vcftools
Tagcloud (Difference) ?		addressed africa allele anaemia breastfeeding comparatively falciparum ferritin haematological haemoglobin hb household id income odds outweigh plasmodium preventable rs855791 rural rwanda rwandan saharan southern substantially tended thalassaemia uncommon verified	archive bcl6 cancerous cebpb checked cufflinks david deg degs downloaded exph5 fastqc hg19 msx2 noiseq paracancerous ppp2r2c read samtools sox4 srp009386 tophat totally transfa trp53 uniquely v1 vcftools
Tagcloud (Intersection) ?