TMPRSS6

Gene Name		transmembrane protease, serine 6
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding
	Biological Process	Angiogenesis Proteolysis Extracellular Matrix Organization Negative Regulation Of BMP Signaling Pathway Intracellular Signal Transduction Fibrinolysis Iron Ion Homeostasis
Pathways
Drugs
Diseases
GWAS		Glycated hemoglobin levels ( 20858683) Hematocrit ( 19862010) Hematological and biochemical traits ( 20139978) Hematological parameters ( 19820697) Hematology traits ( 23263863 19853236) Hemoglobin ( 19820698 19862010) Hepcidin levels ( 21785125) Iron levels ( 19880490 21208937) Iron status biomarkers ( 21149283 19820699 19084217) Mean corpuscular hemoglobin ( 23263863 20139978 19862010) Mean corpuscular hemoglobin concentration ( 23263863 20139978) Mean corpuscular volume ( 23263863 20139978 19862010) Red blood cell traits ( 20927387 23222517)
Protein-protein Interactions		3 interactors: COL1A1 FN1 LAMA1
Entrez ID		164656
HPRD ID		10270
Ensembl ID		ENSG00000187045
Uniprot IDs		Q8IU80
PDB IDs
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Blood Vessel Development Vasculature Development Extracellular Matrix Disassembly Cardiovascular System Development Cellular Response To Fluoride Positive Regulation Of Cell Morphogenesis Involved In Differentiation Locomotion Platelet Activation Tooth Eruption Response To Fluoride Movement Of Cell Or Subcellular Component Leukocyte Migration Tissue Development Calcium-independent Cell-matrix Adhesion Retinal Blood Vessel Morphogenesis Cellular Response To Vitamin E Establishment Of Epithelial Cell Apical/basal Polarity Establishment Of Apical/basal Cell Polarity Polarized Epithelial Cell Differentiation Blood Coagulation Blood Vessel Morphogenesis Hemostasis Anatomical Structure Morphogenesis Regulation Of Cell Morphogenesis Establishment Of Monopolar Cell Polarity Intramembranous Ossification Tooth Mineralization Positive Regulation Of Cell Development Bone Trabecula Formation Protein Heterotrimerization Integrin Activation Retina Vasculature Morphogenesis In Camera-type Eye Collagen Biosynthetic Process Regulation Of Body Fluid Levels Regulation Of Cell Migration Wound Healing Regulation Of Cell Adhesion Regulation Of Cell Motility Establishment Of Epithelial Cell Polarity Bone Trabecula Morphogenesis Regulation Of Locomotion Cell Activation Response To Vitamin E Regulation Of Cellular Component Movement Response To Wounding Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Cell Morphogenesis Involved In Differentiation Retina Vasculature Development In Camera-type Eye
Tagcloud ?		addressed africa allele anaemia breastfeeding comparatively falciparum ferritin haematological haemoglobin hb household id income odds outweigh plasmodium preventable rs855791 rural rwanda rwandan saharan southern substantially tended thalassaemia uncommon verified