PLCB1 and NHERF1

Number of citations of the paper that reports this interaction (PubMedID 10980202)
0

Data Source:
HPRD (in vitro, in vivo)

		PLCB1	NHERF1
Description		phospholipase C beta 1	NHERF family PDZ scaffold protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Cytoplasm Cytosol Membrane Nuclear Speck Nuclear Membrane Protein-containing Complex Extracellular Exosome Glutamatergic Synapse GABA-ergic Synapse Postsynaptic Cytosol	Ruffle Nucleus Cytoplasm Plasma Membrane Microvillus Endomembrane System Actin Cytoskeleton Membrane Apical Plasma Membrane Filopodium Brush Border Membrane Microvillus Membrane Vesicle Stereocilium Stereocilium Tip Cell Projection Apical Part Of Cell Perinuclear Region Of Cytoplasm Extracellular Exosome Cell Periphery Sperm Midpiece Plasma Membrane Protein Complex
	Molecular Function	Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Phospholipase C Activity GTPase Activator Activity Calcium Ion Binding Protein Binding Calmodulin Binding Lamin Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphoric Diester Hydrolase Activity Hydrolase Activity Enzyme Binding Identical Protein Binding Phosphatidylinositol Phospholipase C Activity	Signaling Receptor Binding Protein Binding Beta-catenin Binding Gamma-aminobutyric Acid Transmembrane Transporter Activity Chloride Channel Regulator Activity Phosphatase Binding PDZ Domain Binding Beta-2 Adrenergic Receptor Binding Type 2 Metabotropic Glutamate Receptor Binding Type 3 Metabotropic Glutamate Receptor Binding Identical Protein Binding Protein-membrane Adaptor Activity Dopamine Receptor Binding Molecular Adaptor Activity Growth Factor Receptor Binding Channel Activator Activity
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Lipid Metabolic Process Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Glutamate Receptor Signaling Pathway Learning Memory Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Glycoprotein Biosynthetic Process Lipid Catabolic Process Cerebral Cortex Development Phosphatidylinositol Catabolic Process Positive Regulation Of Insulin Secretion Positive Regulation Of Interleukin-12 Production Inositol Trisphosphate Metabolic Process Response To Monosaccharide Intracellular Signal Transduction Interleukin-12-mediated Signaling Pathway Interleukin-15-mediated Signaling Pathway Positive Regulation Of Embryonic Development Response To Peptide Hormone Fat Cell Differentiation Positive Regulation Of Myoblast Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of JNK Cascade Phosphatidylinositol Metabolic Process Insulin-like Growth Factor Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Developmental Growth Release Of Sequestered Calcium Ion Into Cytosol Activation Of Meiosis Involved In Egg Activation Interleukin-1-mediated Signaling Pathway Regulation Of Fertilization Postsynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Retrograde Trans-synaptic Signaling By Endocanabinoid Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Cellular Response To Fluoride Regulation Of Establishment Of Endothelial Barrier Cellular Response To Vasopressin Cellular Response To Ionomycin Cellular Response To Glyceraldehyde Ligand-gated Ion Channel Signaling Pathway Positive Regulation Of Acrosome Reaction Negative Regulation Of Monocyte Extravasation	Morphogenesis Of An Epithelium Renal Sodium Ion Transport Sodium Ion Transport Plasma Membrane Organization Nuclear Migration Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Sensory Perception Of Sound Intracellular Protein Localization Negative Regulation Of Cell Population Proliferation Regulation Of Cell Shape Regulation Of Cell Size Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Fibroblast Migration Negative Regulation Of Fibroblast Migration Negative Regulation Of Sodium Ion Transport Wnt Signaling Pathway Gland Morphogenesis Microvillus Assembly Actin Cytoskeleton Organization Intracellular Phosphate Ion Homeostasis Bile Acid Secretion Glutathione Transport Cilium Organization Establishment Of Epithelial Cell Apical/basal Polarity Maintenance Of Epithelial Cell Apical/basal Polarity Regulation Of Protein Kinase Activity Negative Regulation Of Mitotic Cell Cycle Establishment Of Localization In Cell Establishment Of Golgi Localization Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Gamma-aminobutyric Acid Import Auditory Receptor Cell Stereocilium Organization Phospholipase C-activating Dopamine Receptor Signaling Pathway Protein-containing Complex Assembly Renal Absorption Negative Regulation Of ERK1 And ERK2 Cascade Protein Localization To Plasma Membrane Negative Regulation Of Canonical Wnt Signaling Pathway Cerebrospinal Fluid Circulation Renal Phosphate Ion Absorption Import Across Plasma Membrane Transport Across Blood-brain Barrier Regulation Of Renal Phosphate Excretion Negative Regulation Of Cell Motility Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		PLC beta mediated events PLC beta mediated events Synthesis of IP3 and IP4 in the cytosol Acetylcholine regulates insulin secretion Acetylcholine regulates insulin secretion Ca2+ pathway G alpha (q) signalling events G alpha (q) signalling events G beta:gamma signalling through PLC beta Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Presynaptic function of Kainate receptors
Drugs
Diseases		Early infantile epileptic encephalopathy; Ohtahara syndrome	Nephrolithiasis/osteoporosis, hypophosphatemic
GWAS		Adverse response to drug ( 30420678) Chronic kidney disease ( 26420894) Cognitive performance ( 20125193 19734545) Colorectal cancer ( 23263487) Daytime sleep phenotypes ( 27126917) Diastolic blood pressure ( 28135244) Estimated glomerular filtration rate ( 31451708 31152163) Fasting glucose ( 34074324) Femur bone mineral density x serum urate levels interaction ( 34046847) Hematocrit ( 32888494) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Lateral ventricle temporal horn volume ( 31530798) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494) Mean platelet volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Metabolite levels ( 23823483) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494) Neuritic plaque ( 31497858) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Obstructive sleep apnea trait (average respiratory event duration) ( 26977737) Platelet count ( 27863252 32888494) Platelet distribution width ( 27863252 32888494) Plateletcrit ( 27863252 32888494) Response to irinotecan in non-small-cell lung cancer ( 22664479) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Social communication problems ( 24564958) Suicide ideation score in major depressive disorder ( 26079190) White blood cell count ( 32888494 27863252)
Interacting Genes		18 interacting genes: CEP76 CTBP1 CTBP2 GNAQ GRK2 MAPK1 MAPK3 NHERF1 PARD3 PARD6A PRKCA PRKCD RGS12 RGS4 SPTBN1 TFCP2 TRPC3 TRPM7	67 interacting genes: ABCC2 ABCC4 ACE2 ADRB2 AKAP10 AKT1 APPBP2 ATP6V1B1 ATP6V1E1 BCL10 BCL2A1 BRSK2 CDK1 CEBPA CFTR CLCN3 CNGA2 CRABP1 CTNNB1 DLGAP4 EGFR EZR GNA11 GNAQ GRK6 KCNJ1 LHCGR LPAR2 MSN NF2 NOS2 OGT OPRK1 P2RY1 PAG1 PDGFRA PDGFRB PHLPP1 PIN1 PLCB1 PLCB2 PRKCA PTEN PTH1R RDX RLBP1 SCN4A SKP2 SLC13A1 SLC22A11 SLC22A4 SLC22A5 SLC22A9 SLC26A3 SLC34A1 SLC4A7 SLC4A8 SLC9A3 SLCO1A2 SLCO3A1 TBC1D10A TRPC4 TRPC5 UBE3A YAP1 YES1 ZNF468
Entrez ID		23236	9368
HPRD ID		06177	05406
Ensembl ID		ENSG00000182621	ENSG00000109062
Uniprot IDs		Q9NQ66	O14745
PDB IDs			1G9O 1GQ4 1GQ5 1I92 1SGH 2D10 2JXO 2KJD 2KRG 2M0T 2M0U 2M0V 2OZF 4JL7 4LMM 4MPA 4N6X 4PQW 4Q3H 6RQR
Enriched GO Terms of Interacting Partners?		Viral Genome Replication Protein Phosphorylation Protein Serine/threonine Kinase Activity Phosphorylation Interleukin-34-mediated Signaling Pathway G Protein-coupled Receptor Signaling Pathway Regulation Of Transport Protein Kinase Activity Plasma Membrane Protein Kinase C Signaling Regulation Of Cellular Localization Caveolin-mediated Endocytosis Regulation Of Golgi Inheritance Positive Regulation Of Macrophage Proliferation Regulation Of System Process Viral Process PAR Polarity Complex Regulation Of G Protein-coupled Receptor Signaling Pathway Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Cardiac Neural Crest Cell Development Involved In Heart Development Phosphatase Binding Trachea Formation Establishment Or Maintenance Of Apical/basal Cell Polarity Regulation Of Platelet Activation Protein Serine Kinase Activity Kinase Activity Regulation Of Multicellular Organismal Process Outer Ear Morphogenesis ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Negative Regulation Of Glial Cell Apoptotic Process Bergmann Glial Cell Differentiation Regulation Of Signal Transduction Regulation Of Cardiac Muscle Hypertrophy Regulation Of Biological Quality Regulation Of Muscle System Process White Fat Cell Differentiation Diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Golgi Organization MAP Kinase Activity Myelination Axon Ensheathment Pseudopodium Regulation Of Early Endosome To Late Endosome Transport Regulation Of Cell Communication Regulation Of Signaling Regulation Of Cytoskeleton Organization Schwann Cell Development Intracellular Chemical Homeostasis Ruffle	Apical Plasma Membrane Plasma Membrane Monoatomic Ion Transport Transmembrane Transport Basolateral Plasma Membrane Regulation Of Biological Quality Membrane Sodium Ion Transport Organic Anion Transport Monoatomic Ion Transmembrane Transport PDZ Domain Binding System Process Monoatomic Cation Transport Metal Ion Transport Cellular Response To Oxygen-containing Compound Inorganic Ion Transmembrane Transport Carboxylic Acid Transport Organic Acid Transport Cellular Homeostasis Regulation Of MAPK Cascade Homeostatic Process Regulation Of Intracellular PH Regulation Of Cellular PH Regulation Of Transport Response To Lipid Inorganic Cation Transmembrane Transport Regulation Of Protein Localization Intracellular Chemical Homeostasis Monoatomic Cation Transmembrane Transport Regulation Of PH Organic Anion Transmembrane Transporter Activity Microvillus Positive Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Localization Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Localization To Early Endosome Sodium-independent Organic Anion Transmembrane Transporter Activity Monoatomic Anion Transmembrane Transport Monocarboxylic Acid Transport Chemical Homeostasis Enzyme Binding Regulation Of Signaling Regulation Of Cell Communication Intracellular Monoatomic Cation Homeostasis Solute:inorganic Anion Antiporter Activity Positive Regulation Of Protein Localization To Endosome Inorganic Anion Transport Monoatomic Anion Transport Intracellular Monoatomic Ion Homeostasis
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