PLCB1 and SPTBN1

Number of citations of the paper that reports this interaction (PubMedID 20936779)
36

Data Source:
BioGRID (two hybrid)

		PLCB1	SPTBN1
Description		phospholipase C beta 1	spectrin beta, non-erythrocytic 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Cytoplasm Cytosol Membrane Nuclear Speck Nuclear Membrane Protein-containing Complex Extracellular Exosome Glutamatergic Synapse GABA-ergic Synapse Postsynaptic Cytosol	Nucleus Nucleolus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Spectrin Postsynaptic Density Spectrin-associated Cytoskeleton Membrane Cell Junction Axolemma Cortical Cytoskeleton Cortical Actin Cytoskeleton M Band Cuticular Plate Protein-containing Complex Cell Projection Extracellular Exosome Postsynapse Glutamatergic Synapse
	Molecular Function	Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Phospholipase C Activity GTPase Activator Activity Calcium Ion Binding Protein Binding Calmodulin Binding Lamin Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphoric Diester Hydrolase Activity Hydrolase Activity Enzyme Binding Identical Protein Binding Phosphatidylinositol Phospholipase C Activity	RNA Binding Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Calmodulin Binding Phospholipid Binding Ankyrin Binding Protein-containing Complex Binding Cadherin Binding Actin Filament Binding GTPase Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Lipid Metabolic Process Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Glutamate Receptor Signaling Pathway Learning Memory Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Glycoprotein Biosynthetic Process Lipid Catabolic Process Cerebral Cortex Development Phosphatidylinositol Catabolic Process Positive Regulation Of Insulin Secretion Positive Regulation Of Interleukin-12 Production Inositol Trisphosphate Metabolic Process Response To Monosaccharide Intracellular Signal Transduction Interleukin-12-mediated Signaling Pathway Interleukin-15-mediated Signaling Pathway Positive Regulation Of Embryonic Development Response To Peptide Hormone Fat Cell Differentiation Positive Regulation Of Myoblast Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of JNK Cascade Phosphatidylinositol Metabolic Process Insulin-like Growth Factor Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Developmental Growth Release Of Sequestered Calcium Ion Into Cytosol Activation Of Meiosis Involved In Egg Activation Interleukin-1-mediated Signaling Pathway Regulation Of Fertilization Postsynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Retrograde Trans-synaptic Signaling By Endocanabinoid Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Cellular Response To Fluoride Regulation Of Establishment Of Endothelial Barrier Cellular Response To Vasopressin Cellular Response To Ionomycin Cellular Response To Glyceraldehyde Ligand-gated Ion Channel Signaling Pathway Positive Regulation Of Acrosome Reaction Negative Regulation Of Monocyte Extravasation	Mitotic Cytokinesis Plasma Membrane Organization Central Nervous System Development Vesicle-mediated Transport Central Nervous System Formation Actin Cytoskeleton Organization Positive Regulation Of Interleukin-2 Production Golgi To Plasma Membrane Protein Transport Actin Filament Capping Regulation Of SMAD Protein Signal Transduction Membrane Assembly Protein Localization To Plasma Membrane Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Protein Localization To Plasma Membrane
Pathways		PLC beta mediated events PLC beta mediated events Synthesis of IP3 and IP4 in the cytosol Acetylcholine regulates insulin secretion Acetylcholine regulates insulin secretion Ca2+ pathway G alpha (q) signalling events G alpha (q) signalling events G beta:gamma signalling through PLC beta Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Presynaptic function of Kainate receptors	Nephrin family interactions NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins RAF/MAP kinase cascade COPI-mediated anterograde transport RHOU GTPase cycle RHOV GTPase cycle Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea Signaling by FLT3 fusion proteins Signaling by FLT3 fusion proteins
Drugs			Calcium 1D-myo-inositol 1,4,5-trisphosphate
Diseases		Early infantile epileptic encephalopathy; Ohtahara syndrome
GWAS		Adverse response to drug ( 30420678) Chronic kidney disease ( 26420894) Cognitive performance ( 20125193 19734545) Colorectal cancer ( 23263487) Daytime sleep phenotypes ( 27126917) Diastolic blood pressure ( 28135244) Estimated glomerular filtration rate ( 31451708 31152163) Fasting glucose ( 34074324) Femur bone mineral density x serum urate levels interaction ( 34046847) Hematocrit ( 32888494) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Lateral ventricle temporal horn volume ( 31530798) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494) Mean platelet volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Metabolite levels ( 23823483) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494) Neuritic plaque ( 31497858) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Obstructive sleep apnea trait (average respiratory event duration) ( 26977737) Platelet count ( 27863252 32888494) Platelet distribution width ( 27863252 32888494) Plateletcrit ( 27863252 32888494) Response to irinotecan in non-small-cell lung cancer ( 22664479) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Social communication problems ( 24564958) Suicide ideation score in major depressive disorder ( 26079190) White blood cell count ( 32888494 27863252)	Age-related hearing impairment ( 34108613) Basophil percentage of white cells ( 32888494) Bone mineral density (spine) ( 19079262 18445777 19801982) Bone properties (heel) ( 24430505) Bone ultrasound measurement (broadband ultrasound attenuation) ( 28472463) Bone ultrasound measurement (velocity of sound) ( 28472463) Chronic kidney disease ( 31152163) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31152163) Fractures ( 30158200) Heel bone mineral density ( 28869591 30598549) Height ( 31562340) HOMA-B (corrected for HOMA-IR) ( 30369944) Intraocular pressure ( 30591961 29785010 29617998 30054594 31959993) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lumbar spine bone mineral density ( 22504420 29499414) Lumbar spine bone mineral density (integral) ( 27476799) Lumbar spine bone mineral density (trabecular) ( 27476799) Mean platelet volume ( 32888494) Myopia (pathological) ( 22685421) Neutrophil count ( 32888494) Pars triangularis volume ( 31530798) PR interval ( 32439900) Red blood cell count ( 32888494) Refractive error ( 32231278) Serum alkaline phosphatase levels ( 33547301) Urate levels ( 31578528) White blood cell count ( 32888494)
Interacting Genes		18 interacting genes: CEP76 CTBP1 CTBP2 GNAQ GRK2 MAPK1 MAPK3 NHERF1 PARD3 PARD6A PRKCA PRKCD RGS12 RGS4 SPTBN1 TFCP2 TRPC3 TRPM7	59 interacting genes: ACTR1A ANK2 APC ATF7IP CAPN1 CDC5L CEP63 COPB1 CPNE1 CPNE4 CSNK2A1 CTNNA1 DSCAM DSCR9 DYRK1A EIF3H EPB41 EPB41L3 FTCD GOLGA6L10 GRB2 GRIA2 HSPB1 ITSN1 MAPK14 MEF2C NF2 NOP53 NRIP1 PACSIN1 PCNT PJA1 PKNOX1 PLCB1 PLEKHA5 PRKACA PTEN PYGO1 RINT1 RNF10 SEPTIN8 SH3BP5 SMAD3 SMAD4 SMAD9 SNAPIN SNCA SPTAN1 SREBF2 STAT1 STXBP1 SUMO2 THAP3 TNIK TRAF3IP1 TTC3 YWHAG ZNF251 ZNF512B
Entrez ID		23236	6711
HPRD ID		06177	01683
Ensembl ID		ENSG00000182621	ENSG00000115306
Uniprot IDs		Q9NQ66	B2ZZ89 Q01082
PDB IDs			1AA2 1BKR 3EDV
Enriched GO Terms of Interacting Partners?		Viral Genome Replication Protein Phosphorylation Protein Serine/threonine Kinase Activity Phosphorylation Interleukin-34-mediated Signaling Pathway G Protein-coupled Receptor Signaling Pathway Regulation Of Transport Protein Kinase Activity Plasma Membrane Protein Kinase C Signaling Regulation Of Cellular Localization Caveolin-mediated Endocytosis Regulation Of Golgi Inheritance Positive Regulation Of Macrophage Proliferation Regulation Of System Process Viral Process PAR Polarity Complex Regulation Of G Protein-coupled Receptor Signaling Pathway Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Cardiac Neural Crest Cell Development Involved In Heart Development Phosphatase Binding Trachea Formation Establishment Or Maintenance Of Apical/basal Cell Polarity Regulation Of Platelet Activation Protein Serine Kinase Activity Kinase Activity Regulation Of Multicellular Organismal Process Outer Ear Morphogenesis ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Negative Regulation Of Glial Cell Apoptotic Process Bergmann Glial Cell Differentiation Regulation Of Signal Transduction Regulation Of Cardiac Muscle Hypertrophy Regulation Of Biological Quality Regulation Of Muscle System Process White Fat Cell Differentiation Diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Golgi Organization MAP Kinase Activity Myelination Axon Ensheathment Pseudopodium Regulation Of Early Endosome To Late Endosome Transport Regulation Of Cell Communication Regulation Of Signaling Regulation Of Cytoskeleton Organization Schwann Cell Development Intracellular Chemical Homeostasis Ruffle	Cytosol Intracellular Signal Transduction Cytoplasm Regulation Of Protein Stability Cytoskeletal Protein Binding Regulation Of Transport Signal Transduction In Response To DNA Damage Negative Regulation Of Cell Cycle Phase Transition DNA Damage Checkpoint Signaling SMAD Protein Complex Protein Stabilization Regulation Of Protein Localization Positive Regulation Of Metabolic Process Heteromeric SMAD Protein Complex Glutamatergic Synapse Regulation Of Cellular Component Organization Regulation Of Intracellular Transport Negative Regulation Of Protein Catabolic Process Signal Transduction Negative Regulation Of Cell Cycle Process Regulation Of Protein Catabolic Process Negative Regulation Of Protein Metabolic Process Cytoskeleton Osteoblast Differentiation Regulation Of Cell Communication Regulation Of Biological Quality Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Intracellular Transport Negative Regulation Of Protein-containing Complex Assembly Negative Regulation Of Intracellular Signal Transduction Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Ligand-gated Ion Channel Signaling Pathway Postsynapse Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Signal Transduction Positive Regulation Of Transcription By RNA Polymerase II Vesicle-mediated Transport In Synapse Regulation Of SNARE Complex Assembly Positive Regulation Of Protein Localization Regulation Of Cell Cycle Phase Transition Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transport I-SMAD Binding Positive Regulation Of RNA Metabolic Process Negative Regulation Of Cellular Component Organization Cell Junction Organization
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