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PLCB1 and PARD6A
Number of citations of the paper that reports this interaction (PMID
15782111
)
7
Data Source:
HPRD
(in vivo)
PLCB1
PARD6A
Gene Name
phospholipase C, beta 1 (phosphoinositide-specific)
par-6 family cell polarity regulator alpha
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nuclear Chromatin
Nucleus
Cytoplasm
Cytosol
Nuclear Speck
Nuclear Membrane
Extracellular Vesicular Exosome
Ruffle
Nucleus
Cytosol
Plasma Membrane
Tight Junction
Cell Cortex
Protein Complex
Apical Part Of Cell
Molecular Function
Phosphatidylinositol Phospholipase C Activity
Signal Transducer Activity
GTPase Activator Activity
Calcium Ion Binding
Calmodulin Binding
Lamin Binding
Phosphatidylinositol-4,5-bisphosphate Binding
Enzyme Binding
Protein Homodimerization Activity
Protein Kinase C Binding
Protein Binding
Transcription Factor Binding
Rho GTPase Binding
GTP-dependent Protein Binding
Biological Process
G2/M Transition Of Mitotic Cell Cycle
Signal Transduction
G-protein Coupled Acetylcholine Receptor Signaling Pathway
Glutamate Receptor Signaling Pathway
Synaptic Transmission
Memory
Metabolic Process
Regulation Of G-protein Coupled Receptor Protein Signaling Pathway
Lipid Catabolic Process
Cerebral Cortex Development
Positive Regulation Of Interleukin-12 Production
Intracellular Signal Transduction
Interleukin-12-mediated Signaling Pathway
Interleukin-15-mediated Signaling Pathway
Positive Regulation Of Embryonic Development
Positive Regulation Of GTPase Activity
Inositol Phosphate Metabolic Process
Small Molecule Metabolic Process
Fat Cell Differentiation
Positive Regulation Of Myoblast Differentiation
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of JNK Cascade
Phosphatidylinositol Metabolic Process
Insulin-like Growth Factor Receptor Signaling Pathway
Positive Regulation Of Developmental Growth
Activation Of Meiosis Involved In Egg Activation
Interleukin-1-mediated Signaling Pathway
Regulation Of Fertilization
Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Positive Regulation Of Acrosome Reaction
Negative Regulation Of Monocyte Extravasation
Positive Regulation Of CD24 Biosynthetic Process
Cell Cycle
Transforming Growth Factor Beta Receptor Signaling Pathway
Viral Process
Cell Junction Assembly
Cell-cell Junction Organization
Cell-cell Junction Maintenance
Cell Division
Tight Junction Assembly
Pathways
G alpha (q) signalling events
Signaling by GPCR
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
Integration of energy metabolism
G beta:gamma signalling through PLC beta
Signaling by Wnt
Synthesis of IP3 and IP4 in the cytosol
Gastrin-CREB signalling pathway via PKC and MAPK
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
PLC beta mediated events
G-protein beta:gamma signalling
Opioid Signalling
Regulation of insulin secretion
G-protein mediated events
Activation of Kainate Receptors upon glutamate binding
Inositol phosphate metabolism
beta-catenin independent WNT signaling
Presynaptic function of Kainate receptors
G alpha (q) signalling events
GPCR downstream signaling
Acetylcholine regulates insulin secretion
Ca2+ pathway
Free fatty acids regulate insulin secretion
Transmission across Chemical Synapses
Loss of Function of TGFBR2 in Cancer
Cell junction organization
TGFBR2 MSI Frameshift Mutants in Cancer
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
SMAD2/3 Phosphorylation Motif Mutants in Cancer
Tight junction interactions
Loss of Function of SMAD2/3 in Cancer
TGFBR2 Kinase Domain Mutants in Cancer
SMAD2/3 MH2 Domain Mutants in Cancer
Loss of Function of SMAD4 in Cancer
TGFBR1 KD Mutants in Cancer
Signaling by Wnt
TGFBR1 LBD Mutants in Cancer
Loss of Function of TGFBR1 in Cancer
beta-catenin independent WNT signaling
Cell-cell junction organization
Signaling by TGF-beta Receptor Complex
Signaling by TGF-beta Receptor Complex in Cancer
Asymmetric localization of PCP proteins
PCP/CE pathway
SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS
Cognitive performance (
20125193
19734545
)
Colorectal cancer (
23263487
)
Response to irinotecan in non-small-cell lung cancer (
22664479
)
Obesity-related traits (
23251661
)
Protein-Protein Interactions
17 interactors:
CEP76
CTBP1
CTBP2
GNAQ
MAPK1
MAPK3
PARD3
PARD6A
PRKCA
PRKCD
RGS12
RGS4
SLC9A3R1
SPTBN1
TFCP2
TRPC3
TRPM7
24 interactors:
CDC42
CDH5
CRB3
DVL2
ECT2
GLS
MAP2K5
MARK2
MARK4
PARD3
PARD6B
PLCB1
PLCB3
PRKCG
PRKCH
PRKCI
PRKCZ
RAC1
RHOQ
TCP10
TGFBR1
WDR83
YWHAH
YWHAZ
Entrez ID
23236
50855
HPRD ID
06177
06316
Ensembl ID
ENSG00000182621
ENSG00000102981
Uniprot IDs
Q9NQ66
Q9NPB6
PDB IDs
1WMH
Enriched GO Terms of Interacting Partners
?
Platelet Activation
Wound Healing
Regulation Of Cellular Amino Acid Metabolic Process
Negative Regulation Of Phosphorylation
Regulation Of Protein Phosphorylation
Response To Wounding
Blood Coagulation
Hemostasis
Regulation Of Protein Kinase Activity
Regulation Of Kinase Activity
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Regulation Of Cellular Ketone Metabolic Process
Regulation Of Phosphorylation
Enzyme Linked Receptor Protein Signaling Pathway
Regulation Of MAP Kinase Activity
Cell Cycle
Regulation Of Body Fluid Levels
Cellular Response To Growth Factor Stimulus
Negative Regulation Of Protein Phosphorylation
Regulation Of Cellular Protein Metabolic Process
Response To Growth Factor
Regulation Of Golgi Inheritance
Regulation Of MAPK Cascade
Regulation Of Phosphorus Metabolic Process
Negative Regulation Of MAPK Cascade
Caveolin-mediated Endocytosis
Epidermal Growth Factor Receptor Signaling Pathway
Cell Activation
Peptidyl-threonine Phosphorylation
Fibroblast Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Regulation Of Protein Metabolic Process
Activation Of Phospholipase C Activity
Cellular Response To Fibroblast Growth Factor Stimulus
Positive Regulation Of Phospholipase C Activity
Response To Fibroblast Growth Factor
Regulation Of Golgi Organization
Negative Regulation Of Cellular Protein Metabolic Process
Neurotrophin TRK Receptor Signaling Pathway
Termination Of Signal Transduction
Negative Regulation Of Protein Kinase Activity
Phospholipase C-activating Dopamine Receptor Signaling Pathway
Neurotrophin Signaling Pathway
Protein Phosphorylation
Negative Regulation Of Glial Cell Apoptotic Process
Negative Regulation Of Kinase Activity
Regulation Of Cytoskeleton Organization
Positive Regulation Of Phospholipase Activity
Negative Regulation Of Protein Metabolic Process
Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Intracellular Signal Transduction
Enzyme Linked Receptor Protein Signaling Pathway
Cell-cell Junction Organization
Nervous System Development
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Signaling
Cell Communication
Tight Junction Assembly
Signal Transduction
Regulation Of Cell Death
Regulation Of Cellular Component Organization
System Development
Positive Regulation Of Signal Transduction
Apical Junction Assembly
Positive Regulation Of Kinase Activity
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Transport
Establishment Or Maintenance Of Cell Polarity
Regulation Of Cellular Localization
Regulation Of Apoptotic Process
Positive Regulation Of Transferase Activity
Cell Junction Assembly
Multicellular Organismal Development
Cellular Response To Growth Factor Stimulus
Positive Regulation Of Phosphorylation
Positive Regulation Of Programmed Cell Death
Response To Growth Factor
Generation Of Neurons
Wound Healing
Anatomical Structure Development
Cellular Response To Stimulus
Positive Regulation Of Cell Death
Cell-cell Junction Assembly
Neurogenesis
Regulation Of Establishment Of Protein Localization
Regulation Of Phosphorylation
Response To Wounding
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Cell Projection Organization
Regulation Of Cell Projection Organization
Regulation Of Protein Phosphorylation
Developmental Process
Regulation Of Protein Localization
Regulation Of Kinase Activity
Cellular Component Assembly
Regulation Of Phosphorus Metabolic Process
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Catalytic Activity
Positive Regulation Of Cell Differentiation
Regulation Of Cell Differentiation
Tagcloud
?
450k
arrays
cdkn2a
deregulated
epigenomic
exome
fate
gabrb3
harboring
hnscc
hoxc12
hoxc6
inactivated
mbd
parp15
pax
pax1
pax5
pik3ap1
pursued
seq
slco4c1
somatic
throughput
tsgs
uncovered
uppps
uvulopalatopharyngoplasty
zic4
Tagcloud (Difference)
?
450k
arrays
cdkn2a
deregulated
epigenomic
exome
fate
gabrb3
harboring
hnscc
hoxc12
hoxc6
inactivated
mbd
parp15
pax
pax1
pax5
pik3ap1
pursued
seq
slco4c1
somatic
throughput
tsgs
uncovered
uppps
uvulopalatopharyngoplasty
zic4
Tagcloud (Intersection)
?