PLCB1 and CEP76

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		PLCB1	CEP76
Gene Name		phospholipase C, beta 1 (phosphoinositide-specific)	centrosomal protein 76kDa
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleus Cytoplasm Cytosol Nuclear Speck Nuclear Membrane Extracellular Vesicular Exosome	Centrosome Centriole Cytosol Protein Complex
	Molecular Function	Phosphatidylinositol Phospholipase C Activity Signal Transducer Activity GTPase Activator Activity Calcium Ion Binding Calmodulin Binding Lamin Binding Phosphatidylinositol-4,5-bisphosphate Binding Enzyme Binding Protein Homodimerization Activity	Protein Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Signal Transduction G-protein Coupled Acetylcholine Receptor Signaling Pathway Glutamate Receptor Signaling Pathway Synaptic Transmission Memory Metabolic Process Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Lipid Catabolic Process Cerebral Cortex Development Positive Regulation Of Interleukin-12 Production Intracellular Signal Transduction Interleukin-12-mediated Signaling Pathway Interleukin-15-mediated Signaling Pathway Positive Regulation Of Embryonic Development Positive Regulation Of GTPase Activity Inositol Phosphate Metabolic Process Small Molecule Metabolic Process Fat Cell Differentiation Positive Regulation Of Myoblast Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of JNK Cascade Phosphatidylinositol Metabolic Process Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Developmental Growth Activation Of Meiosis Involved In Egg Activation Interleukin-1-mediated Signaling Pathway Regulation Of Fertilization Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Acrosome Reaction Negative Regulation Of Monocyte Extravasation Positive Regulation Of CD24 Biosynthetic Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Organelle Organization Regulation Of Centriole Replication
Pathways		G alpha (q) signalling events Signaling by GPCR Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Integration of energy metabolism G beta:gamma signalling through PLC beta Signaling by Wnt Synthesis of IP3 and IP4 in the cytosol Gastrin-CREB signalling pathway via PKC and MAPK Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell PLC beta mediated events G-protein beta:gamma signalling Opioid Signalling Regulation of insulin secretion G-protein mediated events Activation of Kainate Receptors upon glutamate binding Inositol phosphate metabolism beta-catenin independent WNT signaling Presynaptic function of Kainate receptors G alpha (q) signalling events GPCR downstream signaling Acetylcholine regulates insulin secretion Ca2+ pathway Free fatty acids regulate insulin secretion Transmission across Chemical Synapses	Organelle biogenesis and maintenance Loss of proteins required for interphase microtubule organizationÂ from the centrosome Loss of Nlp from mitotic centrosomes G2/M Transition Assembly of the primary cilium Centrosome maturation Regulation of PLK1 Activity at G2/M Transition Mitotic G2-G2/M phases Anchoring of the basal body to the plasma membrane Recruitment of mitotic centrosome proteins and complexes Cell Cycle, Mitotic
Drugs
Diseases
GWAS		Cognitive performance ( 20125193 19734545) Colorectal cancer ( 23263487) Response to irinotecan in non-small-cell lung cancer ( 22664479)
Protein-Protein Interactions		17 interactors: CEP76 CTBP1 CTBP2 GNAQ MAPK1 MAPK3 PARD3 PARD6A PRKCA PRKCD RGS12 RGS4 SLC9A3R1 SPTBN1 TFCP2 TRPC3 TRPM7	48 interactors: AKAP7 BANP BZRAP1 C22orf39 CABP5 CCDC92 CCNK CIR1 COIL CRYBA4 CSNK1G1 CUTC DCTD DZIP1L EAF1 EP400NL FAM90A1 GDAP2 GFAP HSPB7 ILVBL KIAA1143 KIAA1279 KLHDC4 LATS1 MAGEA11 MBD3 NHLRC2 PAICS PARD6B PIN1 PLCB1 POM121 RADIL RNF128 RPL9 SALL2 SH2D4A TBC1D27 TOB2 TSSC4 TTC21A TUFT1 TXNDC9 WDFY3 ZBTB24 ZMAT2 ZNF85
Entrez ID		23236	79959
HPRD ID		06177	12694
Ensembl ID		ENSG00000182621	ENSG00000101624
Uniprot IDs		Q9NQ66	B4DP81 Q8TAP6
PDB IDs
Enriched GO Terms of Interacting Partners?		Platelet Activation Wound Healing Regulation Of Cellular Amino Acid Metabolic Process Negative Regulation Of Phosphorylation Regulation Of Protein Phosphorylation Response To Wounding Blood Coagulation Hemostasis Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Cellular Ketone Metabolic Process Regulation Of Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Regulation Of MAP Kinase Activity Cell Cycle Regulation Of Body Fluid Levels Cellular Response To Growth Factor Stimulus Negative Regulation Of Protein Phosphorylation Regulation Of Cellular Protein Metabolic Process Response To Growth Factor Regulation Of Golgi Inheritance Regulation Of MAPK Cascade Regulation Of Phosphorus Metabolic Process Negative Regulation Of MAPK Cascade Caveolin-mediated Endocytosis Epidermal Growth Factor Receptor Signaling Pathway Cell Activation Peptidyl-threonine Phosphorylation Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Protein Metabolic Process Activation Of Phospholipase C Activity Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Phospholipase C Activity Response To Fibroblast Growth Factor Regulation Of Golgi Organization Negative Regulation Of Cellular Protein Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Termination Of Signal Transduction Negative Regulation Of Protein Kinase Activity Phospholipase C-activating Dopamine Receptor Signaling Pathway Neurotrophin Signaling Pathway Protein Phosphorylation Negative Regulation Of Glial Cell Apoptotic Process Negative Regulation Of Kinase Activity Regulation Of Cytoskeleton Organization Positive Regulation Of Phospholipase Activity Negative Regulation Of Protein Metabolic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Tagcloud ?		450k arrays cdkn2a deregulated epigenomic exome fate gabrb3 harboring hnscc hoxc12 hoxc6 inactivated mbd parp15 pax pax1 pax5 pik3ap1 pursued seq slco4c1 somatic throughput tsgs uncovered uppps uvulopalatopharyngoplasty zic4	ahi1 bardet biedl c2cd3 cc2d2a cc2d2b ccdc135 cilia ciliogenesis ciliopathies dyneins gruber jbts jouberin joubert meckel midasins mks mks6 moxr nephronophthisis nphp nphp1 nphp4 rpgrip1 rpgrip1l tgl throw ttl
Tagcloud (Difference) ?		450k arrays cdkn2a deregulated epigenomic exome fate gabrb3 harboring hnscc hoxc12 hoxc6 inactivated mbd parp15 pax pax1 pax5 pik3ap1 pursued seq slco4c1 somatic throughput tsgs uncovered uppps uvulopalatopharyngoplasty zic4	ahi1 bardet biedl c2cd3 cc2d2a cc2d2b ccdc135 cilia ciliogenesis ciliopathies dyneins gruber jbts jouberin joubert meckel midasins mks mks6 moxr nephronophthisis nphp nphp1 nphp4 rpgrip1 rpgrip1l tgl throw ttl
Tagcloud (Intersection) ?