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PLCB1 and TFCP2
Number of citations of the paper that reports this interaction (PMID
25416956
)
0
Data Source:
BioGRID
(two hybrid)
PLCB1
TFCP2
Gene Name
phospholipase C, beta 1 (phosphoinositide-specific)
transcription factor CP2
Image
No pdb structure
No pdb structure
Gene Ontology Annotations
Cellular Component
Nuclear Chromatin
Nucleus
Cytoplasm
Cytosol
Nuclear Speck
Nuclear Membrane
Extracellular Vesicular Exosome
Cellular_component
Nucleus
Molecular Function
Phosphatidylinositol Phospholipase C Activity
Signal Transducer Activity
GTPase Activator Activity
Calcium Ion Binding
Calmodulin Binding
Lamin Binding
Phosphatidylinositol-4,5-bisphosphate Binding
Enzyme Binding
Protein Homodimerization Activity
DNA Binding
Sequence-specific DNA Binding Transcription Factor Activity
Sequence-specific DNA Binding
Biological Process
G2/M Transition Of Mitotic Cell Cycle
Signal Transduction
G-protein Coupled Acetylcholine Receptor Signaling Pathway
Glutamate Receptor Signaling Pathway
Synaptic Transmission
Memory
Metabolic Process
Regulation Of G-protein Coupled Receptor Protein Signaling Pathway
Lipid Catabolic Process
Cerebral Cortex Development
Positive Regulation Of Interleukin-12 Production
Intracellular Signal Transduction
Interleukin-12-mediated Signaling Pathway
Interleukin-15-mediated Signaling Pathway
Positive Regulation Of Embryonic Development
Positive Regulation Of GTPase Activity
Inositol Phosphate Metabolic Process
Small Molecule Metabolic Process
Fat Cell Differentiation
Positive Regulation Of Myoblast Differentiation
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of JNK Cascade
Phosphatidylinositol Metabolic Process
Insulin-like Growth Factor Receptor Signaling Pathway
Positive Regulation Of Developmental Growth
Activation Of Meiosis Involved In Egg Activation
Interleukin-1-mediated Signaling Pathway
Regulation Of Fertilization
Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Positive Regulation Of Acrosome Reaction
Negative Regulation Of Monocyte Extravasation
Positive Regulation Of CD24 Biosynthetic Process
Transcription, DNA-templated
Regulation Of Transcription From RNA Polymerase II Promoter
Pathways
G alpha (q) signalling events
Signaling by GPCR
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
Integration of energy metabolism
G beta:gamma signalling through PLC beta
Signaling by Wnt
Synthesis of IP3 and IP4 in the cytosol
Gastrin-CREB signalling pathway via PKC and MAPK
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
PLC beta mediated events
G-protein beta:gamma signalling
Opioid Signalling
Regulation of insulin secretion
G-protein mediated events
Activation of Kainate Receptors upon glutamate binding
Inositol phosphate metabolism
beta-catenin independent WNT signaling
Presynaptic function of Kainate receptors
G alpha (q) signalling events
GPCR downstream signaling
Acetylcholine regulates insulin secretion
Ca2+ pathway
Free fatty acids regulate insulin secretion
Transmission across Chemical Synapses
Drugs
Diseases
GWAS
Cognitive performance (
20125193
19734545
)
Colorectal cancer (
23263487
)
Response to irinotecan in non-small-cell lung cancer (
22664479
)
Protein-Protein Interactions
17 interactors:
CEP76
CTBP1
CTBP2
GNAQ
MAPK1
MAPK3
PARD3
PARD6A
PRKCA
PRKCD
RGS12
RGS4
SLC9A3R1
SPTBN1
TFCP2
TRPC3
TRPM7
62 interactors:
ADPRH
APBB1
ASAP3
BAG6
C19orf73
CA1
CASP8
CBX8
CCDC94
CDC73
COIL
DNAJC27
DNAJC5B
DPH1
E2F8
EAF1
EIF5B
EPHA10
FAM64A
FANCL
FARS2
FBXL18
GPANK1
HDAC1
HDAC2
IRAK1BP1
KIAA1598
MAPK1
MAPK14
MAPK8
MOB3C
MORF4L1
MRPL11
MRPL40
MVP
NABP1
NFE4
NOM1
NPEPL1
PHF1
PITPNM1
PLCB1
POLL
POLR3GL
PPIG
PPP1R1B
PPP3R2
PSMD5
RBMS1
RNF2
SDCBP
SIN3A
STMN2
SUMO1
TCEA2
TDRD1
TRAPPC12
TSPAN12
UBP1
YY1
ZCCHC10
ZCCHC12
Entrez ID
23236
7024
HPRD ID
06177
01790
Ensembl ID
ENSG00000182621
ENSG00000135457
Uniprot IDs
Q9NQ66
Q12800
PDB IDs
Enriched GO Terms of Interacting Partners
?
Platelet Activation
Wound Healing
Regulation Of Cellular Amino Acid Metabolic Process
Negative Regulation Of Phosphorylation
Regulation Of Protein Phosphorylation
Response To Wounding
Blood Coagulation
Hemostasis
Regulation Of Protein Kinase Activity
Regulation Of Kinase Activity
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Regulation Of Cellular Ketone Metabolic Process
Regulation Of Phosphorylation
Enzyme Linked Receptor Protein Signaling Pathway
Regulation Of MAP Kinase Activity
Cell Cycle
Regulation Of Body Fluid Levels
Cellular Response To Growth Factor Stimulus
Negative Regulation Of Protein Phosphorylation
Regulation Of Cellular Protein Metabolic Process
Response To Growth Factor
Regulation Of Golgi Inheritance
Regulation Of MAPK Cascade
Regulation Of Phosphorus Metabolic Process
Negative Regulation Of MAPK Cascade
Caveolin-mediated Endocytosis
Epidermal Growth Factor Receptor Signaling Pathway
Cell Activation
Peptidyl-threonine Phosphorylation
Fibroblast Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Regulation Of Protein Metabolic Process
Activation Of Phospholipase C Activity
Cellular Response To Fibroblast Growth Factor Stimulus
Positive Regulation Of Phospholipase C Activity
Response To Fibroblast Growth Factor
Regulation Of Golgi Organization
Negative Regulation Of Cellular Protein Metabolic Process
Neurotrophin TRK Receptor Signaling Pathway
Termination Of Signal Transduction
Negative Regulation Of Protein Kinase Activity
Phospholipase C-activating Dopamine Receptor Signaling Pathway
Neurotrophin Signaling Pathway
Protein Phosphorylation
Negative Regulation Of Glial Cell Apoptotic Process
Negative Regulation Of Kinase Activity
Regulation Of Cytoskeleton Organization
Positive Regulation Of Phospholipase Activity
Negative Regulation Of Protein Metabolic Process
Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Gene Expression
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
RNA Metabolic Process
Transcription, DNA-templated
Nucleobase-containing Compound Metabolic Process
RNA Biosynthetic Process
Cellular Nitrogen Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Biosynthetic Process
Nitrogen Compound Metabolic Process
Cellular Response To DNA Damage Stimulus
Cellular Metabolic Process
Cellular Response To Stress
Chromatin Modification
Cellular Protein Metabolic Process
Histone Modification
Chromatin Organization
Negative Regulation Of Gene Expression
Cell Cycle
Negative Regulation Of Cellular Metabolic Process
Protein Metabolic Process
Histone Deacetylation
Regulation Of Gene Expression
Chromosome Organization
Regulation Of Metabolic Process
Protein Deacetylation
TRIF-dependent Toll-like Receptor Signaling Pathway
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Regulation Of Innate Immune Response
Activation Of Innate Immune Response
Metabolic Process
Negative Regulation Of Transcription, DNA-templated
Enzyme Linked Receptor Protein Signaling Pathway
Cellular Response To Stimulus
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of Biosynthetic Process
Regulation Of Organelle Organization
Negative Regulation Of Gene Expression, Epigenetic
Cellular Protein Modification Process
Negative Regulation Of RNA Biosynthetic Process
Peptidyl-amino Acid Modification
Toll-like Receptor 4 Signaling Pathway
Anatomical Structure Development
Anatomical Structure Morphogenesis
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of Transcription, DNA-templated
Tagcloud
?
450k
arrays
cdkn2a
deregulated
epigenomic
exome
fate
gabrb3
harboring
hnscc
hoxc12
hoxc6
inactivated
mbd
parp15
pax
pax1
pax5
pik3ap1
pursued
seq
slco4c1
somatic
throughput
tsgs
uncovered
uppps
uvulopalatopharyngoplasty
zic4
Tagcloud (Difference)
?
450k
arrays
cdkn2a
deregulated
epigenomic
exome
fate
gabrb3
harboring
hnscc
hoxc12
hoxc6
inactivated
mbd
parp15
pax
pax1
pax5
pik3ap1
pursued
seq
slco4c1
somatic
throughput
tsgs
uncovered
uppps
uvulopalatopharyngoplasty
zic4
Tagcloud (Intersection)
?