FAF2 and VASP

Number of citations of the paper that reports this interaction (PubMedID 35044719)
104

Data Source:
BioGRID (unspecified method)

		FAF2	VASP
Description		Fas associated factor family member 2	vasodilator stimulated phosphoprotein
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GO Annotations	Cellular Component	Extracellular Region Cytoplasm Endoplasmic Reticulum Lipid Droplet VCP-NPL4-UFD1 AAA ATPase Complex Azurophil Granule Lumen	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Bicellular Tight Junction Focal Adhesion Actin Cytoskeleton Membrane Lamellipodium Filopodium Lamellipodium Membrane Filopodium Membrane Cell Projection Extracellular Exosome Anchoring Junction Postsynapse Glutamatergic Synapse
	Molecular Function	Protein Binding Protein-macromolecule Adaptor Activity Ubiquitin Protein Ligase Binding Lipase Binding Ubiquitin Binding Lipase Inhibitor Activity	Actin Binding Protein Binding Profilin Binding SH3 Domain Binding Cadherin Binding
	Biological Process	Response To Unfolded Protein Proteasomal Protein Catabolic Process Retrograde Protein Transport, ER To Cytosol Lipid Droplet Organization Stress Granule Disassembly ERAD Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Neural Tube Closure Axon Guidance Actin Polymerization Or Depolymerization Actin Cytoskeleton Organization Positive Regulation Of Actin Filament Polymerization Protein Homotetramerization
Pathways		Neutrophil degranulation RHOA GTPase cycle	Generation of second messenger molecules Signaling by ROBO receptors Signaling by ROBO receptors Cell-extracellular matrix interactions
Drugs
Diseases
GWAS		Cirrhosis (alcohol related) ( 32853455)	Alzheimer's disease or HDL levels (pleiotropy) ( 30805717)
Interacting Genes		13 interacting genes: ELAVL1 FAF1 FAS MAP3K1 OGT PCAT1 PNPLA2 PSMD2 SMURF1 UBC UBE2D1 UBE3A VASP	49 interacting genes: ABI1 ABI2 ABI3 ACTA1 ACTG1 AEBP1 APBB1 APBB1IP CDC42 CEBPA DMRTB1 DNMBP ENAH ERMAP FAF2 FAT1 FRS3 FYB1 GSN IQGAP1 LPP MAGED1 MRPL43 NOL3 NR4A1 PFN1 PFN2 PLSCR1 PRKACA PRKG1 PRPF40A PSORS1C2 RAD51 RAPH1 SAT1 SCGB2A2 SHROOM3 SPTA1 TES TRIM15 TRIM9 VCL WAS WASL WWP2 XIRP1 XIRP2 XPO6 ZYX
Entrez ID		23197	7408
HPRD ID		16870	03415
Ensembl ID		ENSG00000113194	ENSG00000125753
Uniprot IDs		Q96CS3	A0A024R0V4 P50552
PDB IDs		2DAM	1EGX 1USD 1USE 2PAV 2PBD 3CHW 8GAT 8GAU
Enriched GO Terms of Interacting Partners?		Fas Signaling Pathway Modification-dependent Protein Catabolic Process CD95 Death-inducing Signaling Complex Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Proteolysis Response To Nutrient Levels Positive Regulation Of Protein Metabolic Process Proteasomal Protein Catabolic Process Cytosol Catabolic Process Cellular Response To Nutrient Levels Ubiquitin-dependent Protein Catabolic Process Regulation Of TORC1 Signaling Regulation Of Protein Metabolic Process Macromolecule Catabolic Process Protein Catabolic Process Regulation Of TOR Signaling Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Ubiquitination Positive Regulation Of Autophagosome Size Positive Regulation Of Catabolic Process Glutamatergic Synapse Protein Metabolic Process Intracellular Chemical Homeostasis Sperm Entry Positive Regulation Of Golgi Lumen Acidification Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Engulfment Of Target By Autophagosome Regulation Of Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Modification Process Proteasome Complex Positive Regulation Of Reactive Oxygen Species Metabolic Process Protein Ubiquitination Negative Regulation Of TORC1 Signaling TORC1 Signaling Positive Regulation Of TORC1 Signaling Negative Regulation Of BMP Signaling Pathway Protein Polyubiquitination Cellular Homeostasis Cellular Response To Mechanical Stimulus Regulation Of Stem Cell Population Maintenance Proteasome Storage Granule Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Protein Modification By Small Protein Conjugation Positive Regulation Of Metabolic Process Signal Transduction	Actin Filament Organization Focal Adhesion Lamellipodium Supramolecular Fiber Organization Actin Filament-based Process Anchoring Junction Actin Cytoskeleton Organization Cytoskeleton Filopodium Actin Cytoskeleton Cytoplasm Actin Binding Actin Polymerization Or Depolymerization Regulation Of Actin Filament Organization Cytoskeleton Organization Cell-cell Junction Regulation Of Actin Cytoskeleton Organization Cytosol Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Actin-based Cell Projection Actin Filament Binding Cellular Response To Type II Interferon SCAR Complex Phagocytic Vesicle Regulation Of Cell Projection Assembly Regulation Of Lamellipodium Assembly Actin Filament Stress Fiber Modification Of Postsynaptic Actin Cytoskeleton Regulation Of Stress Fiber Assembly Organelle Organization Response To Type II Interferon Cell Projection Morphogenesis Regulation Of Lamellipodium Organization Regulation Of Cytoskeleton Organization Adherens Junction SH3 Domain Binding Cortical Actin Cytoskeleton Modification Of Postsynaptic Structure Negative Regulation Of Cellular Component Organization Cell Leading Edge Modification Of Synaptic Structure Cell Projection Organization Cell Junction Organization Actin Cap Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Ruffle Assembly Actin Filament Polymerization
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