FAF2 and ELAVL1

Number of citations of the paper that reports this interaction (PubMedID 23618873)
58

Data Source:
BioGRID (pull down)

		FAF2	ELAVL1
Description		Fas associated factor family member 2	ELAV like RNA binding protein 1
Image
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Endoplasmic Reticulum Lipid Droplet VCP-NPL4-UFD1 AAA ATPase Complex Azurophil Granule Lumen	P-body Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol Cytoplasmic Stress Granule Membrane Sarcoplasm Cytoplasmic Vesicle Postsynapse Glutamatergic Synapse Ribonucleoprotein Complex
	Molecular Function	Protein Binding Protein-macromolecule Adaptor Activity Ubiquitin Protein Ligase Binding Lipase Binding Ubiquitin Binding Lipase Inhibitor Activity	Nucleic Acid Binding RNA Binding Double-stranded RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding Protein Kinase Binding MiRNA Binding MRNA 3'-UTR AU-rich Region Binding Protein Homodimerization Activity LncRNA Binding
	Biological Process	Response To Unfolded Protein Proteasomal Protein Catabolic Process Retrograde Protein Transport, ER To Cytosol Lipid Droplet Organization Stress Granule Disassembly ERAD Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	LncRNA-mediated Post-transcriptional Gene Silencing Protein Import Into Nucleus Cell Population Proliferation Response To Glucose Positive Regulation Of Autophagy Post-transcriptional Gene Silencing Positive Regulation Of Superoxide Anion Generation Regulation Of MRNA Stability Positive Regulation Of Translation Positive Regulation Of Autophagosome Size MRNA Stabilization Protein Homooligomerization Negative Regulation Of MiRNA-mediated Gene Silencing MRNA Destabilization 3'-UTR-mediated MRNA Stabilization Regulation Of Stem Cell Population Maintenance
Pathways		Neutrophil degranulation RHOA GTPase cycle	HuR (ELAVL1) binds and stabilizes mRNA
Drugs
Diseases
GWAS		Cirrhosis (alcohol related) ( 32853455)
Interacting Genes		13 interacting genes: ELAVL1 FAF1 FAS MAP3K1 OGT PCAT1 PNPLA2 PSMD2 SMURF1 UBC UBE2D1 UBE3A VASP	44 interacting genes: AKT1 ANP32A ANP32B APOE C12orf75 CARM1 CEBPA CELF2 CHEK2 CTNNB1 ERG FAF2 GJB3 HNRNPK HOTAIR IL6 IL7R KPNA1 KPNB1 LINC00460 LINC00632 MIRLET7B MIRLET7I NEIL3 NOS3 PAIP2 PLAU PLAUR PRKCA PRKCD PRKCE PSEN2 PTBP2 PTGS2 RBFOX2 SDCBP SET SHANK3 SREK1 TNPO1 TNPO2 TRIM21 VCP VEGFA
Entrez ID		23197	1994
HPRD ID		16870	16025
Ensembl ID		ENSG00000113194	ENSG00000066044
Uniprot IDs		Q96CS3	Q15717
PDB IDs		2DAM	3HI9 4ED5 4EGL 4FXV 5SZW 6G2K 6GC5 6GD1 6GD2 6GD3
Enriched GO Terms of Interacting Partners?		Fas Signaling Pathway Modification-dependent Protein Catabolic Process CD95 Death-inducing Signaling Complex Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Proteolysis Response To Nutrient Levels Positive Regulation Of Protein Metabolic Process Proteasomal Protein Catabolic Process Cytosol Catabolic Process Cellular Response To Nutrient Levels Ubiquitin-dependent Protein Catabolic Process Regulation Of TORC1 Signaling Regulation Of Protein Metabolic Process Macromolecule Catabolic Process Protein Catabolic Process Regulation Of TOR Signaling Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Ubiquitination Positive Regulation Of Autophagosome Size Positive Regulation Of Catabolic Process Glutamatergic Synapse Protein Metabolic Process Intracellular Chemical Homeostasis Sperm Entry Positive Regulation Of Golgi Lumen Acidification Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Engulfment Of Target By Autophagosome Regulation Of Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Modification Process Proteasome Complex Positive Regulation Of Reactive Oxygen Species Metabolic Process Protein Ubiquitination Negative Regulation Of TORC1 Signaling TORC1 Signaling Positive Regulation Of TORC1 Signaling Negative Regulation Of BMP Signaling Pathway Protein Polyubiquitination Cellular Homeostasis Cellular Response To Mechanical Stimulus Regulation Of Stem Cell Population Maintenance Proteasome Storage Granule Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Protein Modification By Small Protein Conjugation Positive Regulation Of Metabolic Process Signal Transduction	Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Signal Transduction Negative Regulation Of Programmed Cell Death Enzyme Binding Regulation Of Primary Metabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Nuclear Import Signal Receptor Activity Regulation Of Signal Transduction Regulation Of Platelet Activation Nuclear Localization Sequence Binding Regulation Of Macromolecule Metabolic Process Stress Granule Disassembly Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Endothelial Cell Migration Regulation Of Cell Communication Regulation Of Signaling Regulation Of Gene Expression Regulation Of Intracellular Signal Transduction Regulation Of Blood Coagulation Positive Regulation Of Catabolic Process Intracellular Signaling Cassette Regulation Of Fat Cell Differentiation Regulation Of Hemostasis Regulation Of Wound Healing Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Lipid Metabolic Process Regulation Of Cell Population Proliferation Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Multicellular Organismal Process Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Response To Oxidative Stress Positive Regulation Of Developmental Process Intracellular Signal Transduction Regulation Of Response To Wounding Urokinase Plasminogen Activator Signaling Pathway Positive Regulation Of Lipid Biosynthetic Process Negative Regulation Of Blood Coagulation Regulation Of Body Fluid Levels Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Cell Differentiation Diacylglycerol-dependent Serine/threonine Kinase Activity
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