FAF2 and PNPLA2

Number of citations of the paper that reports this interaction (PMID 23297223)
8

Data Source:
BioGRID (affinity chromatography technology, protein complementation assay)

		FAF2	PNPLA2
Gene Name		Fas associated factor family member 2	patatin-like phospholipase domain containing 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Lipid Particle Cdc48p-Npl4p-Ufd1p AAA ATPase Complex Intracellular Membrane-bounded Organelle	Endoplasmic Reticulum Membrane Lipid Particle Cytosol Plasma Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding Lipase Binding Ubiquitin Binding Lipase Inhibitor Activity	Triglyceride Lipase Activity
	Biological Process	Response To Unfolded Protein Lipid Particle Organization Negative Regulation Of Catalytic Activity	Phospholipid Metabolic Process Negative Regulation Of Sequestering Of Triglyceride Positive Regulation Of Triglyceride Catabolic Process Triglyceride Catabolic Process Lipid Storage Lipid Particle Organization Acylglycerol Acyl-chain Remodeling Small Molecule Metabolic Process Glycerophospholipid Biosynthetic Process
Pathways			Metabolism of lipids and lipoproteins Acyl chain remodeling of DAG and TAG Phospholipid metabolism Glycerophospholipid biosynthesis
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: FAF1 FAS NF1 PNPLA2 PSMD2 UBE2D1 UBQLN2	10 interactors: ABHD5 ARFGEF2 CYTH2 FAF2 GBF1 MARK3 PHYHIP SERPINF1 SMAD9 UBE2R2
Entrez ID		23197	57104
HPRD ID		16870	11443
Ensembl ID		ENSG00000113194	ENSG00000177666
Uniprot IDs		Q96CS3	Q96AD5
PDB IDs		2DAM
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Cellular Protein Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Proteolysis Regulation Of Protein Metabolic Process Negative Regulation Of Transferase Activity Apoptotic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Programmed Cell Death Cell Death Death Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Catalytic Activity Negative Regulation Of Transcription Factor Import Into Nucleus Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of Protein Catabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Signal Transduction Negative Regulation Of Protein Import Into Nucleus Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Negative Regulation Of Protein Localization To Nucleus Ubiquitin-dependent Protein Catabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Apoptotic Process Negative Regulation Of Intracellular Protein Transport Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Transcription Factor Import Into Nucleus Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Catalytic Activity Triglyceride Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Cell Death Forebrain Astrocyte Development Cellular Protein Catabolic Process Negative Regulation Of Protein Ubiquitination Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death	Regulation Of ARF Protein Signal Transduction Regulation Of Catalytic Activity Positive Regulation Of Hydrolase Activity Post-Golgi Vesicle-mediated Transport Cellular Response To Cobalt Ion Regulation Of Ras Protein Signal Transduction Positive Regulation Of Catalytic Activity Negative Regulation Of Sequestering Of Triglyceride Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Triglyceride Catabolic Process Regulation Of GTPase Activity Mullerian Duct Regression Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Receptor Recycling Response To Cobalt Ion Golgi Vesicle Transport Short-term Memory COPI-coated Vesicle Budding Positive Regulation Of Lipoprotein Lipase Activity COPI Coating Of Golgi Vesicle Positive Regulation Of Metabolic Process
Tagcloud ?			abhd5 agpat2 anomaly atgl cgi ctgm dgat1 diverge enteropathy gk glycerol gpd1 hsl ichthyosis inborn jordan lipe lipodystrophy loosing lpin1 lpin2 majeed nlsd perilipin pseudohypertriglyceridemia rhabdomyolysis steatosis tgs vacuolated
Tagcloud (Difference) ?			abhd5 agpat2 anomaly atgl cgi ctgm dgat1 diverge enteropathy gk glycerol gpd1 hsl ichthyosis inborn jordan lipe lipodystrophy loosing lpin1 lpin2 majeed nlsd perilipin pseudohypertriglyceridemia rhabdomyolysis steatosis tgs vacuolated
Tagcloud (Intersection) ?