FAF2 and PNPLA2

Number of citations of the paper that reports this interaction (PubMedID 37218505)
57

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, protein complementation assay)

		FAF2	PNPLA2
Description		Fas associated factor family member 2	patatin like domain 2, triacylglycerol lipase
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Endoplasmic Reticulum Lipid Droplet VCP-NPL4-UFD1 AAA ATPase Complex Azurophil Granule Lumen	Nucleoplasm Cytoplasm Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Lipid Droplet Cytosol Plasma Membrane Membrane
	Molecular Function	Protein Binding Protein-macromolecule Adaptor Activity Ubiquitin Protein Ligase Binding Lipase Binding Ubiquitin Binding Lipase Inhibitor Activity	Lipoprotein Lipase Activity Phospholipase A2 Activity Triacylglycerol Lipase Activity Protein Binding Acylglycerol O-acyltransferase Activity Hydrolase Activity Retinyl-palmitate Esterase Activity Mono-olein Transacylation Activity Diolein Transacylation Activity
	Biological Process	Response To Unfolded Protein Proteasomal Protein Catabolic Process Retrograde Protein Transport, ER To Cytosol Lipid Droplet Organization Stress Granule Disassembly ERAD Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Retinoid Metabolic Process Lipid Metabolic Process Acylglycerol Metabolic Process Diacylglycerol Biosynthetic Process Phototransduction, Visible Light Negative Regulation Of Triglyceride Storage Positive Regulation Of Triglyceride Catabolic Process Lipid Catabolic Process Triglyceride Catabolic Process Lipid Storage Lipid Droplet Organization Intracellular Triglyceride Homeostasis Acylglycerol Acyl-chain Remodeling Retinol Metabolic Process Lipid Homeostasis Lipid Droplet Fusion Lipid Droplet Disassembly
Pathways		Neutrophil degranulation RHOA GTPase cycle	Acyl chain remodeling of DAG and TAG Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Drugs
Diseases
GWAS		Cirrhosis (alcohol related) ( 32853455)	A body shape index ( 34021172) Body fat distribution (arm fat ratio) ( 30664634) HDL cholesterol levels ( 32203549) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Keratoconus ( 31855235) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		13 interacting genes: ELAVL1 FAF1 FAS MAP3K1 OGT PCAT1 PNPLA2 PSMD2 SMURF1 UBC UBE2D1 UBE3A VASP	10 interacting genes: ABHD5 ARFGEF2 CYTH2 FAF2 GBF1 MARK3 PHYHIP SERPINF1 SMAD9 UBE2R2
Entrez ID		23197	57104
HPRD ID		16870	11443
Ensembl ID		ENSG00000113194	ENSG00000177666
Uniprot IDs		Q96CS3	Q96AD5
PDB IDs		2DAM
Enriched GO Terms of Interacting Partners?		Fas Signaling Pathway Modification-dependent Protein Catabolic Process CD95 Death-inducing Signaling Complex Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Proteolysis Response To Nutrient Levels Positive Regulation Of Protein Metabolic Process Proteasomal Protein Catabolic Process Cytosol Catabolic Process Cellular Response To Nutrient Levels Ubiquitin-dependent Protein Catabolic Process Regulation Of TORC1 Signaling Regulation Of Protein Metabolic Process Macromolecule Catabolic Process Protein Catabolic Process Regulation Of TOR Signaling Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Ubiquitination Positive Regulation Of Autophagosome Size Positive Regulation Of Catabolic Process Glutamatergic Synapse Protein Metabolic Process Intracellular Chemical Homeostasis Sperm Entry Positive Regulation Of Golgi Lumen Acidification Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Engulfment Of Target By Autophagosome Regulation Of Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Modification Process Proteasome Complex Positive Regulation Of Reactive Oxygen Species Metabolic Process Protein Ubiquitination Negative Regulation Of TORC1 Signaling TORC1 Signaling Positive Regulation Of TORC1 Signaling Negative Regulation Of BMP Signaling Pathway Protein Polyubiquitination Cellular Homeostasis Cellular Response To Mechanical Stimulus Regulation Of Stem Cell Population Maintenance Proteasome Storage Granule Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Protein Modification By Small Protein Conjugation Positive Regulation Of Metabolic Process Signal Transduction	Regulation Of ARF Protein Signal Transduction Endomembrane System Organization Lipid Droplet Guanyl-nucleotide Exchange Factor Activity Protein Localization To Endoplasmic Reticulum Tubular Network Regulation Of Small GTPase Mediated Signal Transduction
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