ABCG8 and NUPR1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		ABCG8	NUPR1
Gene Name		ATP-binding cassette, sub-family G (WHITE), member 8	nuclear protein, transcriptional regulator, 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Apical Plasma Membrane ATP-binding Cassette (ABC) Transporter Complex Receptor Complex	Nucleus Cytoplasm
	Molecular Function	Protein Binding ATP Binding ATPase Activity Cholesterol Transporter Activity Protein Heterodimerization Activity	Molecular_function DNA Binding Chromatin Binding
	Biological Process	Response To Nutrient Excretion Negative Regulation Of Intestinal Phytosterol Absorption Phospholipid Transport Sterol Transport Intestinal Cholesterol Absorption Cholesterol Efflux Response To Drug Cholesterol Homeostasis Small Molecule Metabolic Process Negative Regulation Of Intestinal Cholesterol Absorption Transmembrane Transport	Acute Inflammatory Response Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein Complex Assembly Protein Acetylation Male Gonad Development Response To Toxic Substance Cell Growth Positive Regulation Of Protein Modification Process Skeletal Muscle Cell Differentiation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Apoptotic Process Negative Regulation Of Cell Cycle Negative Regulation Of Fibroblast Proliferation Regulation Of Female Gonad Development
Pathways		Metabolism of lipids and lipoproteins ABC-family proteins mediated transport Lipid digestion, mobilization, and transport Trafficking of dietary sterols ABCA transporters in lipid homeostasis
Drugs
Diseases
GWAS		Cholesterol, total ( 20686565) Gallstones ( 17632509) LDL cholesterol ( 23726366 19060906 20686565) Lipid metabolism phenotypes ( 19936222) Phytosterol levels ( 20529992)	Inflammatory bowel disease ( 23128233) Inflammatory bowel disease (early onset) ( 19915574)
Protein-Protein Interactions		8 interactors: ABCG5 AGPAT2 AKT2 ANG LMNB1 MAL2 NR4A1 NUPR1	21 interactors: ABCG8 ALDH1A1 EP300 FUS KNSTRN MAPRE1 MPHOSPH6 MSL1 NACA NONO NPY5R PAXIP1 PSMD4 PTMA RAN RANBP1 RPL41 SEC11A SET STX18 SYNCRIP
Entrez ID		64241	26471
HPRD ID		05679	17814
Ensembl ID		ENSG00000143921	ENSG00000176046
Uniprot IDs		Q9H221	O60356
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Lipid Transport Apoptotic Process Programmed Cell Death Cell Death Skeletal Muscle Cell Differentiation Death Positive Regulation Of Endothelial Cell Proliferation Regulation Of Endothelial Cell Proliferation Regulation Of Lipid Transport Neutral Lipid Metabolic Process Negative Regulation Of Intestinal Phytosterol Absorption Negative Regulation Of Intestinal Cholesterol Absorption Skeletal Muscle Tissue Development Skeletal Muscle Organ Development Tissue Development Positive Regulation Of Epithelial Cell Proliferation Diacylglycerol Biosynthetic Process Activation Of Ral GTPase Activity Activation Of Phospholipase A2 Activity Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phospholipase A2 Activity Positive Regulation Of Glucose Import In Response To Insulin Stimulus Positive Regulation Of Protein Modification Process Response To Hormone Positive Regulation Of Ral GTPase Activity Regulation Of Ral Protein Signal Transduction Gonad Development Regulation Of Protein Metabolic Process Development Of Primary Sexual Characteristics Intestinal Cholesterol Absorption Regulation Of Intestinal Cholesterol Absorption Regulation Of Translation Muscle Organ Development Regulation Of Epithelial Cell Proliferation Positive Regulation Of Cellular Protein Metabolic Process Sex Differentiation Regulation Of Glucose Import In Response To Insulin Stimulus Negative Regulation Of Cholesterol Transport Positive Regulation Of Fatty Acid Beta-oxidation CDP-diacylglycerol Biosynthetic Process Positive Regulation Of Vesicle Fusion Regulation Of Phospholipase A2 Activity Striated Muscle Tissue Development Positive Regulation Of Cellular Metabolic Process Regulation Of Female Gonad Development CDP-diacylglycerol Metabolic Process Lipid Digestion Positive Regulation Of Protein Transport Angiogenesis	Viral Process Gene Expression Positive Regulation Of Protein Binding Mitotic Cell Cycle Cellular Nitrogen Compound Metabolic Process Regulation Of Organelle Organization Cell Cycle Signal Transduction By P53 Class Mediator Nitrogen Compound Metabolic Process Positive Regulation Of Binding Spindle Organization Cell Cycle Process Mitotic Cell Cycle Process Regulation Of Microtubule Cytoskeleton Organization Regulation Of Protein Binding Regulation Of Microtubule-based Process Nucleobase-containing Compound Metabolic Process Organelle Organization Regulation Of Histone Acetylation RNA Metabolic Process Histone H4 Acetylation Protein Localization To Organelle Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Apoptotic Process Histone H2B Acetylation Negative Regulation Of Transcription From RNA Polymerase II Promoter Involved In Heart Development Positive Regulation Of Histone H3-K36 Methylation Generation Of Ovulation Cycle Rhythm Negative Regulation Of Programmed Cell Death MRNA Metabolic Process Negative Regulation Of Cell Death Peptidyl-lysine Modification Regulation Of Binding Mitotic Cell Cycle Phase Transition Intracellular Transport Cell Cycle Phase Transition Chromosome Organization Negative Regulation Of Intestinal Phytosterol Absorption Negative Regulation Of Intestinal Cholesterol Absorption Cellular Process Rhythmic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Mitotic Nuclear Division Ribosomal Small Subunit Export From Nucleus Positive Regulation Of ER To Golgi Vesicle-mediated Transport N-terminal Peptidyl-lysine Acetylation Positive Regulation Of Microtubule Plus-end Binding Endoplasmic Reticulum Membrane Organization Positive Regulation Of Skeletal Muscle Tissue Growth
Tagcloud ?		abca1 abcg5 atorvastatin causal challenging chow excised fads1 gwas hfd hypertensive list loci lpl madd nominally nr1h3 orthologs overlapped pcsk9 pltp qpcr qtl responded spontaneously stac3 staged suggestive timd4	95d altered arrest atpase c3orf1 carcinoma ccng2 col3a1 concurrently depleted depletion ecm focal inner introducing justified lung microarray migration mitochondrial notably preliminary pten remarkably timmdc1 timp3 translocase upregulated viable
Tagcloud (Difference) ?		abca1 abcg5 atorvastatin causal challenging chow excised fads1 gwas hfd hypertensive list loci lpl madd nominally nr1h3 orthologs overlapped pcsk9 pltp qpcr qtl responded spontaneously stac3 staged suggestive timd4	95d altered arrest atpase c3orf1 carcinoma ccng2 col3a1 concurrently depleted depletion ecm focal inner introducing justified lung microarray migration mitochondrial notably preliminary pten remarkably timmdc1 timp3 translocase upregulated viable
Tagcloud (Intersection) ?