ABCG8 and MAL2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		ABCG8	MAL2
Description		ATP binding cassette subfamily G member 8	mal, T cell differentiation protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Apical Plasma Membrane ATP-binding Cassette (ABC) Transporter Complex Receptor Complex	Cytoplasm Plasma Membrane Endomembrane System Membrane Apical Plasma Membrane Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Protein Binding ATP Binding ATP Hydrolysis Activity ATPase-coupled Transmembrane Transporter Activity Metal Ion Binding Protein Heterodimerization Activity Protein Dimerization Activity Cholesterol Transfer Activity ABC-type Transporter Activity	Protein Binding Structural Constituent Of Myelin Sheath
	Biological Process	Lipid Transport Response To Nutrient Response To Xenobiotic Stimulus Negative Regulation Of Intestinal Phytosterol Absorption Response To Muscle Activity Phospholipid Transport Sterol Transport Intestinal Cholesterol Absorption Response To Nutrient Levels Cholesterol Efflux Cholesterol Homeostasis Negative Regulation Of Intestinal Cholesterol Absorption Transmembrane Transport Sterol Homeostasis Triglyceride Homeostasis	Myelination
Pathways		ABC transporters in lipid homeostasis Defective ABCG8 causes GBD4 and sitosterolemia Defective ABCG5 causes sitosterolemia NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
Drugs
Diseases		Sitosterolemia
GWAS		Age at first sexual intercourse ( 34211149) Alanine aminotransferase levels ( 34315874 33547301) Apolipoprotein B levels ( 32203549) Aspartate aminotransferase levels ( 34315874) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) Cholesterol, total ( 25961943 28270201 24097068 20686565) Coronary artery disease ( 33020668 29212778 32469254) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Gallstone disease ( 27094239 30504769 30692554 30325047 17632509) LDL cholesterol ( 19060906 20686565 23726366 25961943 30275531) LDL cholesterol levels ( 30698716 32203549) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Lipid metabolism phenotypes ( 19936222) Liver enzyme levels (alanine transaminase) ( 33972514) Low density lipoprotein cholesterol levels ( 33339817 32154731) Mean platelet volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (antithrombotic agents) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Phytosterol levels ( 20529992) Refractive error ( 32231278) Total cholesterol levels ( 30275531 33339817)	Aspartate aminotransferase levels ( 33547301) Blood pressure (smoking interaction) ( 25189868) Gallstone disease ( 30504769) Hippocampal atrophy ( 19668339) Osteoprotegerin levels ( 25080503)
Interacting Genes		9 interacting genes: ABCG5 AGPAT2 AKT2 ANG LMNB1 MAL2 MESD NR4A1 NUPR1	49 interacting genes: ABCG8 AQP6 ARFIP2 ARL13B ATP6V0E1 CD160 CD68 COQ8A CREB3 CREB3L1 ECPAS FAM3A GAD1 GAD2 GJB1 GPR152 HSFX1 HSFX2 MRM1 MTERF3 MUC1 NDRG4 NFAM1 PBX3 PIMREG PITPNC1 POLL PPP1CA PTPN9 RAB37 REEP4 RETREG3 S100B SCN3B SGK1 SH3GL1 SH3GLB1 SHMT2 SLC35H1 SUCLA2 TBRG4 THAP4 TMEM14B TPD52 TPD52L1 TPD52L2 TTPA TUBB VARS2
Entrez ID		64241	114569
HPRD ID		05679	14351
Ensembl ID		ENSG00000143921	ENSG00000147676
Uniprot IDs		Q9H221	Q969L2
PDB IDs		5DO7 7JR7 7R87 7R88 7R89 7R8A 7R8B 8CUB
Enriched GO Terms of Interacting Partners?		Regulation Of Type B Pancreatic Cell Proliferation	Succinate Metabolic Process Gamma-aminobutyrate Shunt Glutamate Decarboxylase Activity Gamma-aminobutyric Acid Biosynthetic Process
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